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Publications (10 of 88) Show all publications
Redzwan Mohd Shah, S., Velander, J., Perez, M. D., Joseph, L., Mattsson, V., Asan, N. B., . . . Augustine, R. (2019). Improved Sensor for Non-invasive Assessment of Burn Injury Depth Using Microwave Reflectometry. In: 2019 13th European Conference on Antennas and Propagation (EuCAP): . Paper presented at 2019 13th European Conference on Antennas and Propagation (EuCAP), 31 March-5 April 2019, Krakow, Poland.
Open this publication in new window or tab >>Improved Sensor for Non-invasive Assessment of Burn Injury Depth Using Microwave Reflectometry
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2019 (English)In: 2019 13th European Conference on Antennas and Propagation (EuCAP), 2019Conference paper, Published paper (Refereed)
Abstract [en]

The European project “Senseburn” aims to develop a non-invasive diagnostic instrument for assessing the depth and propagation of human burns in the clinical scenario. This article introduces an improved flexible microwave split-ring resonator-based sensor, as a new development in this project. The excitation system and the fabrication process are the major improvements with respect to its precedent microwave sensor, both based in polydimethylsiloxane (PDMS) and copper. Both improvements are introduced together with the design of the sensor and of the experimental setup. Human tissue emulating phantoms are designed, fabricated, validated, and employed to emulate different burn depths and to validate the conceptual functionality of the proposed sensor. The Keysight dielectric probe 85070E is employed for the phantom validation. The analysis suggests that the sensor could estimate the burn depth. Future works will be carried out with ex vivo human tissues. 

National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Research subject
Engineering Science with specialization in Microwave Technology
Identifiers
urn:nbn:se:uu:diva-390800 (URN)978-88-907018-8-7 (ISBN)
Conference
2019 13th European Conference on Antennas and Propagation (EuCAP), 31 March-5 April 2019, Krakow, Poland
Available from: 2019-08-14 Created: 2019-08-14 Last updated: 2019-09-17Bibliographically approved
Bergquist, M., Hastbacka, J., Glaumann, C., Fredén, F., Huss, F. & Lipcsey, M. (2019). The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcome. Burns, 45(2), 354-363
Open this publication in new window or tab >>The time-course of the inflammatory response to major burn injury and its relation to organ failure and outcome
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2019 (English)In: Burns, ISSN 0305-4179, E-ISSN 1879-1409, Vol. 45, no 2, p. 354-363Article in journal (Refereed) Published
Abstract [en]

Burn injury causes major inflammatory activation and cytokine release, however, the temporal resolution of the acute and sub-acute inflammatory response has not yet been fully delineated. To this end, we have quantified 20 inflammatory mediators in plasma from 44 adult patients 0-21 days after burn injury and related the time course of these mediators to % total body surface area (TBSA) burned, clinical parameters, organ failure and outcome. Of the cytokines analyzed in these patients, interleukin 6 (IL-6), IL-8, IL-10 and monocyte chemoattractant protein 1 (MCP-1) correlated to the size of the injury at 24-48h after burn injury. In our study, the concentration of IL-10 had prognostic value in patients with burn injury both measured at admission and at 24-48h after injury. However, simple demographic data such as age, % burned TBSA, inhalation injury and their combination, the Baux score and modified Baux score, outperform most of the cytokines, with the exception of IL-8 and MCP1 levels on admission, in predicting death.

Place, publisher, year, edition, pages
ELSEVIER SCI LTD, 2019
Keywords
Cytokines, Burns, Mortality, Multiple organ failure, Severity of illness index
National Category
Anesthesiology and Intensive Care Surgery
Identifiers
urn:nbn:se:uu:diva-380482 (URN)10.1016/j.burns.2018.09.001 (DOI)000461044900012 ()30274808 (PubMedID)
Available from: 2019-04-15 Created: 2019-04-15 Last updated: 2019-04-15Bibliographically approved
Vågesjö, E., Öhnstedt, E., Mortier, A., Lofton Tomenius, H., Huss, F., Proost, P., . . . Phillipson, M. (2018). Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria. Proceedings of the National Academy of Sciences of the United States of America, 115(8), 1895-1900
Open this publication in new window or tab >>Accelerated wound healing in mice by on-site production and delivery of CXCL12 by transformed lactic acid bacteria
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2018 (English)In: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 115, no 8, p. 1895-1900Article in journal (Refereed) Published
Abstract [en]

Impaired wound closure is a growing medical problem associated with metabolic diseases and aging. Immune cells play important roles in wound healing by following instructions from the microenvironment. Here, we developed a technology to bioengineer the wound microenvironment and enhance healing abilities of the immune cells. This resulted in strongly accelerated wound healing and was achieved by transforming Lactobacilli with a plasmid encoding CXCL12. CXCL12-delivering bacteria administrated topically to wounds in mice efficiently enhanced wound closure by increasing proliferation of dermal cells and macrophages, and led to increased TGF-beta expression in macrophages. Bacteria-produced lactic acid reduced the local pH, which inhibited the peptidase CD26 and consequently enhanced the availability of bioactive CXCL12. Importantly, treatment with CXCL12-delivering Lactobacilli also improved wound closure in mice with hyperglycemia or peripheral ischemia, conditions associated with chronic wounds, and in a human skin wound model. Further, initial safety studies demonstrated that the topically applied transformed bacteria exerted effects restricted to the wound, as neither bacteria nor the chemokine produced could be detected in systemic circulation. Development of drugs accelerating wound healing is limited by the proteolytic nature of wounds. Our technology overcomes this by on-site chemokine production and reduced degradation, which together ensure prolonged chemokine bioavailability that instructed local immune cells and enhanced wound healing.

Place, publisher, year, edition, pages
NATL ACAD SCIENCES, 2018
Keywords
macrophage, chemokine, blood flow, diabetes, Lactobacillus reuteri
National Category
Infectious Medicine
Identifiers
urn:nbn:se:uu:diva-349352 (URN)10.1073/pnas.1716580115 (DOI)000425495000072 ()29432190 (PubMedID)
Funder
Swedish Research CouncilSwedish Diabetes AssociationNovo NordiskErnfors FoundationRagnar Söderbergs stiftelseKnut and Alice Wallenberg FoundationVINNOVA
Available from: 2018-04-27 Created: 2018-04-27 Last updated: 2018-04-27Bibliographically approved
Willebrand, M., Sjöberg, F., Huss, F. & Sveen, J. (2018). Parents' perceived quality of pediatric burn care.. Journal of critical care, 43, 256-259
Open this publication in new window or tab >>Parents' perceived quality of pediatric burn care.
2018 (English)In: Journal of critical care, ISSN 0883-9441, E-ISSN 1557-8615, Vol. 43, p. 256-259Article in journal (Refereed) Published
Abstract [en]

PURPOSE: To describe parents' perceived quality of pediatric burn care and evaluate factors associated with differences in perceived quality among parents.

METHODS: 62 parents of children with burns were recruited on a Swedish national basis 0.8 to 5.6years after the child's injury. Measures were an adaptation of the Quality of Care Indices - Parent questionnaire consisting of 8 subscales and one overall question, the Impact of Event Scale -Revised, Montgomery Åsberg Depression Rating Scale, and Injury-specific fear-avoidance.

RESULTS: Ratings of quality of care were high, especially regarding Staff Attitudes, Medical Treatment, and Caring Processes. Overall satisfaction rated from 1 to 10 was on average 9.1 (SD=1.2). Overall satisfaction and specific indices of Quality of care were not associated with burn severity, parent gender, or parent age. However, Quality of care was associated with current symptoms of posttraumatic stress and depression, and parents of girls expressed being less satisfied with Participation.

CONCLUSIONS: Parents' perceived quality of care is associated with psychological health, but not with characteristics of the child's injury or age. The results suggest that burn care can improve by involving parents of girls more and by being more attentive towards parents who themselves appear stressed or worried.

Keywords
Burns, Care, Child, Pediatric, Quality
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-334009 (URN)10.1016/j.jcrc.2017.08.037 (DOI)000418522800042 ()28946104 (PubMedID)
Funder
Swedish Research Council, 2010-3033
Available from: 2017-11-20 Created: 2017-11-20 Last updated: 2018-01-25Bibliographically approved
Jonsson, A., Nilson, F., Bonander, C. & Huss, F. (2018). Seriously injured due to residential fires in Sweden. Injury Prevention, 24, A16-A16
Open this publication in new window or tab >>Seriously injured due to residential fires in Sweden
2018 (English)In: Injury Prevention, ISSN 1353-8047, E-ISSN 1475-5785, Vol. 24, p. A16-A16Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
BMJ Publishing Group Ltd, 2018
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-369053 (URN)10.1136/injuryprevention-2018-safety.44 (DOI)000446617400045 ()
Available from: 2018-12-13 Created: 2018-12-13 Last updated: 2018-12-13Bibliographically approved
Tocco-Tussardi, I., Presman, B. & Huss, F. (2018). Want Correct Percentage of TBSA Burned?: Let a Layman Do the Assessment. Journal of Burn Care & Research, 39(2), 295-301
Open this publication in new window or tab >>Want Correct Percentage of TBSA Burned?: Let a Layman Do the Assessment
2018 (English)In: Journal of Burn Care & Research, ISSN 1559-047X, E-ISSN 1559-0488, Vol. 39, no 2, p. 295-301Article in journal (Refereed) Published
Abstract [en]

Accurate determination of burn size significantly impacts both immediate management and long-term outcome. In the era of evidence-based medicine, the variability in TBSA% assessment shown by traditional methods may prove unacceptable and technology-aided systems become the "accepted standard." The objective of this study was to push this scenario to the limit by investigating the accuracy and consistency of TBSA% estimations using a computer-aided tool. Five Laymen (health care-burn management naive people) were trained on the handling of the technology-aided assessment tool Burn Case 3D(C) and asked to calculate TBSA% for 18 clinical pictures of burns with different patterns and sizes. Forty-four burn Professionals (senior burn surgeons, plastic surgery residents, anesthesiologists, emergency physicians, senior registered nurses) were provided the same pictures and assessed TBSA% using traditional paper-based tools ("Rule of Palm"; "[Wallace] Rule of Nines"; "Lund and Browder chart). The Laymen's computer-aided calculations did not differ significantly (P > .05) from the senior burn surgeons' estimations in 17 of the 18 cases. However, when comparing the Laymen's TBSA% calculations with the whole group Professionals there were significant differences (P < .05) in (again) 17 of the 18 cases. Laymen's calculations were also more consistent (mean SD, 0.95%). The Professionals showed a generalized significant overestimation of TBSA% as compared with the Laymen's calculations (up to 198.5%). Innovative software provide a high potential to improve objectivity and quality of burn assessment in the future.

National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-354259 (URN)10.1097/BCR.0000000000000613 (DOI)000430732500016 ()28877135 (PubMedID)
Available from: 2018-06-29 Created: 2018-06-29 Last updated: 2018-06-29Bibliographically approved
Gonzalez, V., Lindblad, M., Renlund, M., Rangsten, P. & Huss, F. (2017). A first clinical verification of a radio frequency-based spectroscopy sensor intended for glucose detection in interstitial fluid.. Paper presented at The 10th International Conference on Advanced Technologies & Treatments for Diabetes. Paris, France 2017.. Diabetes Technology & Therapeutics, 19(S1)
Open this publication in new window or tab >>A first clinical verification of a radio frequency-based spectroscopy sensor intended for glucose detection in interstitial fluid.
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2017 (English)In: Diabetes Technology & Therapeutics, ISSN 1520-9156, E-ISSN 1557-8593, Vol. 19, no S1Article in journal (Refereed) Published
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-368389 (URN)
Conference
The 10th International Conference on Advanced Technologies & Treatments for Diabetes. Paris, France 2017.
Available from: 2018-12-04 Created: 2018-12-04 Last updated: 2019-02-21
Tanash, H. A., Ringbaek, T., Huss, F. & Ekstrom, M. (2017). Burn injury during long-term oxygen therapy in Denmark and Sweden: the potential role of smoking. The International Journal of Chronic Obstructive Pulmonary Disease, 12, 193-197
Open this publication in new window or tab >>Burn injury during long-term oxygen therapy in Denmark and Sweden: the potential role of smoking
2017 (English)In: The International Journal of Chronic Obstructive Pulmonary Disease, ISSN 1176-9106, E-ISSN 1178-2005, Vol. 12, p. 193-197Article in journal (Refereed) Published
Abstract [en]

Background: Long-term oxygen therapy (LTOT) increases life expectancy in patients with COPD and severe hypoxemia. Smoking is the main cause of burn injury during LTOT. Policy regarding smoking while on LTOT varies between countries. In this study, we compare the incidence of burn injury that required contact with a health care specialist, between Sweden (a country with a strict policy regarding smoking while on LTOT) and Denmark (a country with less strict smoking policy). Methods: This was a population-based, cohort study of patients initiating LTOT due to any cause in Sweden and Denmark. Data on diagnoses, external causes, and procedures were obtained from the Swedish and Danish National Patient Registers for inpatient and outpatient care. Patients were followed from January 1, 2000, until the first of the following: LTOT withdrawal, death, or study end (December 31, 2009). The primary end point was burn injury during LTOT. Results: A total of 23,741 patients received LTOT in Denmark and 7,754 patients in Sweden. Most patients started LTOT due to COPD, both in Sweden (74%) and in Denmark (62%). The rate of burn injury while on LTOT was higher in Denmark than in Sweden; 170 (95% confidence interval [CI], 126-225) vs 85 (95% CI, 44-148) per 100,000 person-years; rate ratio 2.0 (95% CI, 1.0-4.1). The risk remained higher after adjustment for gender, age, and diagnosis in multivariate Cox regression, hazard ratio 1.8 (95% CI, 1.0-3.5). Thirty-day mortality after burn injury was 8% in both countries. Conclusion: Compared to Sweden, the rate of burn injury was twice as high in Denmark where smoking is not a contraindication for prescribing LTOT.

Keywords
burn injury, COPD, long-term oxygen therapy, smoking
National Category
Public Health, Global Health, Social Medicine and Epidemiology Surgery
Identifiers
urn:nbn:se:uu:diva-315062 (URN)10.2147/COPD.S119949 (DOI)000391326600003 ()28123292 (PubMedID)
Funder
Swedish Society of MedicineSwedish Heart Lung Foundation
Available from: 2017-03-01 Created: 2017-03-01 Last updated: 2017-11-29Bibliographically approved
Boissin, C., Fransén, J., Laflamme, L., Allorto, N., Wallis, L., Huss, F. & Lundin, J. (2017). Deep learning for image-based diagnostic support: initial development of a system for acute burns: Constance Boissin. Central European Journal of Public Health, 27(suppl. 3), 436
Open this publication in new window or tab >>Deep learning for image-based diagnostic support: initial development of a system for acute burns: Constance Boissin
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2017 (English)In: Central European Journal of Public Health, ISSN 1210-7778, E-ISSN 1803-1048, Vol. 27, no suppl. 3, p. 436-Article in journal, Meeting abstract (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-334145 (URN)10.1093/eurpub/ckx186.102 (DOI)000414389805014 ()
Available from: 2017-11-21 Created: 2017-11-21 Last updated: 2018-03-19Bibliographically approved
Jonsson, A., Bonander, C., Nilson, F. & Huss, F. (2017). Description of the residential fire fatality problem in Sweden: Epidemiology, risk factors and event typologies. Paper presented at South African Burn Society 17th congress 2017, Cape Town. Wound Healing Southern Africa, 10(1)
Open this publication in new window or tab >>Description of the residential fire fatality problem in Sweden: Epidemiology, risk factors and event typologies
2017 (English)In: Wound Healing Southern Africa, Vol. 10, no 1Article in journal, Meeting abstract (Refereed) Published
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-368388 (URN)
Conference
South African Burn Society 17th congress 2017, Cape Town
Note

Congress abstracts: South African Burn Society 17th congress 2017, Cape Town

Available from: 2018-12-04 Created: 2018-12-04 Last updated: 2019-02-21Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-9735-1434

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