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Benedict, Christian, DocentORCID iD iconorcid.org/000-0002-8911-4068
Publications (10 of 107) Show all publications
Tan, X., van Egmond, L., Partinen, M., Lange, T. & Benedict, C. (2019). A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients. Sleep Medicine, 59, 42-50
Open this publication in new window or tab >>A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients
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2019 (English)In: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 59, p. 42-50Article, review/survey (Refereed) Published
Abstract [en]

Sleep and circadian disruptions are frequently observed in patients across hospital wards. This is alarming, since impaired nocturnal sleep and disruption of a normal circadian rhythm can compromise health and disturb processes involved in recovery from illness (eg, immune functions). With this in mind, the present narrative review discusses how patient characteristics (sleep disorders, anxiety, stress, chronotype, and disease), hospital routines (pain management, timing of medication, nocturnal vital sign monitoring, and physical inactivity), and hospital environment (light and noise) may all contribute to sleep disturbances and circadian misalignment in patients. We also propose hospital-based strategies that may help reduce sleep and circadian disruptions in patients admitted to the hospital. (C) 2018 The Authors. Published by Elsevier B.V.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2019
Keywords
Sleep, Circadian rhythm, Hospital, Inpatients
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-390001 (URN)10.1016/j.sleep.2018.08.007 (DOI)000471665700006 ()30415906 (PubMedID)
Funder
Swedish Research Council, 2015-03100Novo Nordisk, NNF14OC0009349The Swedish Brain Foundation, FO2016-009Ernfors FoundationÅke Wiberg Foundation, M17-0088Fredrik och Ingrid Thurings Stiftelse, 2017-00313
Available from: 2019-08-05 Created: 2019-08-05 Last updated: 2019-08-05Bibliographically approved
Rångtell, F. H., Karamchedu, S., Andersson, P., Liethof, L., Bucaro, M. O., Lampola, L., . . . Benedict, C. (2019). A single night of sleep loss impairs objective but not subjective working memory performance in a sex-dependent manner. Journal of Sleep Research, 28(1), Article ID e12651.
Open this publication in new window or tab >>A single night of sleep loss impairs objective but not subjective working memory performance in a sex-dependent manner
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2019 (English)In: Journal of Sleep Research, ISSN 0962-1105, E-ISSN 1365-2869, Vol. 28, no 1, article id e12651Article in journal (Refereed) Published
Abstract [en]

Acute sleep deprivation can lead to judgement errors and thereby increases the risk of accidents, possibly due to an impaired working memory. However, whether the adverse effects of acute sleep loss on working memory are modulated by auditory distraction in women and men are not known. Additionally, it is unknown whether sleep loss alters the way in which men and women perceive their working memory performance. Thus, 24 young adults (12 women using oral contraceptives at the time of investigation) participated in two experimental conditions: nocturnal sleep (scheduled between 22:30 and 06:30 hours) versus one night of total sleep loss. Participants were administered a digital working memory test in which eight-digit sequences were learned and retrieved in the morning after each condition. Learning of digital sequences was accompanied by either silence or auditory distraction (equal distribution among trials). After sequence retrieval, each trial ended with a question regarding how certain participants were of the correctness of their response, as a self-estimate of working memory performance. We found that sleep loss impaired objective but not self-estimated working memory performance in women. In contrast, both measures remained unaffected by sleep loss in men. Auditory distraction impaired working memory performance, without modulation by sleep loss or sex. Being unaware of cognitive limitations when sleep-deprived, as seen in our study, could lead to undesirable consequences in, for example, an occupational context. Our findings suggest that sleep-deprived young women are at particular risk for overestimating their working memory performance.

Place, publisher, year, edition, pages
John Wiley & Sons, 2019
Keywords
sound distraction, women and men, nocturnal wakefulness, subjective performance, cognition
National Category
Applied Psychology
Identifiers
urn:nbn:se:uu:diva-376724 (URN)10.1111/jsr.12651 (DOI)000456255400005 ()29383809 (PubMedID)
Funder
Fredrik och Ingrid Thurings StiftelseSwedish Research Council, 2015-03100Åke Wiberg FoundationThe Swedish Brain Foundation, FO2016-0092Swedish Society of MedicineTore Nilsons Stiftelse för medicinsk forskningNovo Nordisk, NNF14OC0009349Erik, Karin och Gösta Selanders FoundationAFA Insurance, 140006Swedish Research Council
Available from: 2019-02-11 Created: 2019-02-11 Last updated: 2019-04-23Bibliographically approved
van Egmond, L., Tan, X., Sjögren, P., Cederholm, T. & Benedict, C. (2019). Association between Healthy Dietary Patterns and Self-Reported Sleep Disturbances in Older Men: The ULSAM Study. Nutrients, 11(5), Article ID 1029.
Open this publication in new window or tab >>Association between Healthy Dietary Patterns and Self-Reported Sleep Disturbances in Older Men: The ULSAM Study
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2019 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, no 5, article id 1029Article in journal (Refereed) Published
Abstract [en]

To date, little is known about how dietary patterns may link to measures of sleep quality in older subjects, who often suffer from sleep problems. Here, we investigated, in an older male population from Sweden (n = 970; aged 71 +/- 1 year), whether adherence to the Healthy Diet Indicator (HDI; based on recommendations from the World Health Organization) or the Mediterranean Diet (MD) is linked to sleep disturbances. The diet scores were calculated using a seven-day food diary, and self-reported sleep initiation or maintenance problems were assessed by questionnaires. When adjusted for potential confounders, no associations between dietary scores and sleep parameters were found. In contrast, low consumption of milk and dairy products one of the dietary features of the MD was associated with better subjective sleep initiation. This association was, however, not found in men with adequate reports of daily energy intake (similar to 54% of the cohort). To summarize, our findings do not suggest that older men can mitigate perceived difficulties to fall and stay asleep by adhering to either the HDI or MD. Whether low consumption of milk and dairy products can facilitate sleep initiation must be confirmed in future studies by utilizing objective measures of sleep such as polysomnography. Finally, when investigating associations between dietary patterns and sleep, particular attention should be paid to the potential confounder of inadequate reporting of energy intake.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
mediterranean diet, healthy diet indicator, sleep problems, elderly population, dietary adherence
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:uu:diva-389873 (URN)10.3390/nu11051029 (DOI)000471021600089 ()31071943 (PubMedID)
Funder
Swedish Research Council, 2015-03100Novo Nordisk, NNF14OC0009349The Swedish Brain FoundationÅke Wiberg Foundation, M17-0088Fredrik och Ingrid Thurings Stiftelse, 2017-00313Swedish Society for Medical Research (SSMF)
Available from: 2019-07-31 Created: 2019-07-31 Last updated: 2019-07-31Bibliographically approved
Tan, X., Titova, O. E., Lindberg, E., Elmståhl, S., Lind, L., Schiöth, H. B. & Benedict, C. (2019). Association Between Self-Reported Sleep Duration and Body Composition in Middle-Aged and Older Adults. Journal of Clinical Sleep Medicine (JCSM), 15(3), 431-435
Open this publication in new window or tab >>Association Between Self-Reported Sleep Duration and Body Composition in Middle-Aged and Older Adults
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2019 (English)In: Journal of Clinical Sleep Medicine (JCSM), ISSN 1550-9389, E-ISSN 1550-9397, Vol. 15, no 3, p. 431-435Article in journal (Refereed) Published
Abstract [en]

STUDY OBJECTIVES: The current study sought to examine whether self-reported sleep duration is linked to an adverse body composition in 19,709 adults aged 45 to 75 years.

METHODS: All variables used in the current study were derived from the Swedish EpiHealth cohort study. Habitual sleep duration was measured by questionnaires. Body composition was assessed by bioimpedance. The main outcome variables were fat mass and fat-free mass (in kg). Analysis of covariance adjusting for age, sex, fat mass in the case of fat-free mass (and vice versa), leisure time physical activity, smoking, and alcohol consumption was used to investigate the association between sleep duration and body composition.

RESULTS: Short sleep (defined as ≤ 5 hours sleep per day) and long sleep (defined as 8 or more hours of sleep per day) were associated with lower fat-free mass and higher fat mass, compared with 6 to 7 hours of sleep duration (P< .05).

CONCLUSIONS: These observations could suggest that both habitual short and long sleep may contribute to two common clinical phenotypes in middle-aged and older humans, ie, body adiposity and sarcopenia. However, the observational nature of our study does not allow for causal interpretation.

Keywords
body fat, elderly, fat-free mass, middle-aged, sleep
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-379286 (URN)10.5664/jcsm.7668 (DOI)000461417900009 ()30853046 (PubMedID)
Funder
Swedish Research CouncilNovo Nordisk, NNF14OC0009349Swedish Research Council, 2015-03100Ernfors FoundationÅke Wiberg Foundation, M17-0088Åke Wiberg Foundation, M18-0169Fredrik och Ingrid Thurings Stiftelse, 2017-00313Fredrik och Ingrid Thurings Stiftelse, 2018-00365
Available from: 2019-03-14 Created: 2019-03-14 Last updated: 2019-04-04Bibliographically approved
Tan, X., Cedernaes, J., Risérus, U. & Benedict, C. (2019). Lack of association between self-reported insomnia symptoms and clamp-derived insulin sensitivity in elderly men. Psychoneuroendocrinology, 102, 256-260
Open this publication in new window or tab >>Lack of association between self-reported insomnia symptoms and clamp-derived insulin sensitivity in elderly men
2019 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 102, p. 256-260Article in journal (Refereed) Published
Abstract [en]

Insomnia-related sleep disruptions, such as short and disturbed sleep, have been tied to systemic insulin resistance in young adult populations. We therefore sought to confirm these findings in a cohort of elderly men. To this aim, we utilized variables from 980 men who participated in the investigation at age 70 of the Uppsala Longitudinal Study of Adult Men. Self-reported insomnia symptoms were assessed by questions about difficulty initiating sleep, early final awakening, and regular use of hypnotics. All participants also underwent the gold standard hyperinsulinemic-euglycemic clamp technique to assess the insulin sensitivity index (M/I). Finally, fasting blood was collected to measure free fatty acids (FFAs) and adiponectin. Differences in blood parameters between men with and those without insomnia were determined by ANCOVA, and were adjusted for lifestyle and cardio-metabolic risk factors. Our analysis yielded no differences in M/I, FFAs, and adiponectin between men with and those without insomnia symptoms. Analyses in non-diabetic and diabetic subsamples confirmed these negative findings. Our cross-sectional results therefore suggest that insomnia symptoms may have a minimal effect, if any, on measures of insulin sensitivity in elderly men. Given the observational design of our study, future studies are needed to determine whether experimental sleep manipulations influence systemic insulin sensitivity in elderly humans, as has previously been shown in young adult populations.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD, 2019
Keywords
Male cohort, Insomnia symptoms, Clamp-derived insulin sensitivity, Adiponectin, Free fatty acids
National Category
Physiology
Identifiers
urn:nbn:se:uu:diva-382522 (URN)10.1016/j.psyneuen.2018.12.227 (DOI)000462800900032 ()30594818 (PubMedID)
Funder
Swedish Research Council, 2015-03100Novo Nordisk, NNF14OC0009349The Swedish Brain FoundationÅke Wiberg Foundation, M17-0088Fredrik och Ingrid Thurings Stiftelse, 2017-00313
Available from: 2019-04-29 Created: 2019-04-29 Last updated: 2019-04-29Bibliographically approved
Tan, X., van Egmond, L., Partinen, M., Lange, T. & Benedict, C. (2019). Response to comment on "A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients" [Letter to the editor]. Sleep Medicine, 59, 53-53
Open this publication in new window or tab >>Response to comment on "A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients"
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2019 (English)In: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 59, p. 53-53Article in journal, Letter (Other academic) Published
Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2019
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-390002 (URN)10.1016/j.sleep.2018.10.002 (DOI)000471665700008 ()30553689 (PubMedID)
Available from: 2019-08-05 Created: 2019-08-05 Last updated: 2019-08-05Bibliographically approved
Cedernaes, J., Westholm, O. J. & Benedict, C. (2018). Acute Sleep Leads To Tissue-Specific Epigenetic And Transcriptional Responses In Healthy Humans. Paper presented at 32nd Annual Meeting of the Associated-Professional-Sleep-Societies- LLC, JUN 02-06, 2018, Baltimore, MD. Sleep, 41, A5-A5
Open this publication in new window or tab >>Acute Sleep Leads To Tissue-Specific Epigenetic And Transcriptional Responses In Healthy Humans
2018 (English)In: Sleep, ISSN 0161-8105, E-ISSN 1550-9109, Vol. 41, p. A5-A5Article in journal, Meeting abstract (Other academic) Published
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-357656 (URN)000431183400012 ()
Conference
32nd Annual Meeting of the Associated-Professional-Sleep-Societies- LLC, JUN 02-06, 2018, Baltimore, MD
Available from: 2018-08-28 Created: 2018-08-28 Last updated: 2018-08-28Bibliographically approved
Cedernaes, J., Schonke, M., Westholm, J. O., Mi, J., Chibalin, A., Voisin, S., . . . Benedict, C. (2018). Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans. Science Advances, 4(8), Article ID eaar8590.
Open this publication in new window or tab >>Acute sleep loss results in tissue-specific alterations in genome-wide DNA methylation state and metabolic fuel utilization in humans
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2018 (English)In: Science Advances, E-ISSN 2375-2548, Vol. 4, no 8, article id eaar8590Article in journal (Refereed) Published
Abstract [en]

Curtailed sleep promotes weight gain and loss of lean mass in humans, although the underlying molecular mechanisms are poorly understood. We investigated the genomic and physiological impact of acute sleep loss in peripheral tissues by obtaining adipose tissue and skeletal muscle after one night of sleep loss and after one full night of sleep. We find that acute sleep loss alters genome-wide DNA methylation in adipose tissue, and unbiased transcriptome-, protein-, and metabolite-level analyses also reveal highly tissue-specific changes that are partially reflected by altered metabolite levels in blood. We observe transcriptomic signatures of inflammation in both tissues following acute sleep loss, but changes involving the circadian clock are evident only in skeletal muscle, and we uncover molecular signatures suggestive of muscle breakdown that contrast with an anabolic adipose tissue signature. Our findings provide insight into how disruption of sleep and circadian rhythms may promote weight gain and sarcopenia.

Place, publisher, year, edition, pages
AMER ASSOC ADVANCEMENT SCIENCE, 2018
National Category
Physiology
Identifiers
urn:nbn:se:uu:diva-364473 (URN)10.1126/sciadv.aar8590 (DOI)000443498100025 ()30140739 (PubMedID)
Funder
Swedish Research Council, 2015-03100Knut and Alice Wallenberg FoundationSwedish Research Council, 2014-6888Swedish Research Council, 2016-01088Swedish Research Council, 2016-02195Swedish Research Council, 2015-4870Carl Tryggers foundation Erik, Karin och Gösta Selanders FoundationFredrik och Ingrid Thurings StiftelseLars Hierta Memorial FoundationMagnus Bergvall FoundationNovo NordiskTore Nilsons Stiftelse för medicinsk forskningSwedish Society of Medicine, SLS-694111The Swedish Brain FoundationÅke Wiberg FoundationScience for Life Laboratory - a national resource center for high-throughput molecular bioscience
Available from: 2018-10-31 Created: 2018-10-31 Last updated: 2019-03-15Bibliographically approved
Tan, X., van Egmond, L., Chapman, C. D., Cedernaes, J. & Benedict, C. (2018). Aiding sleep in type 2 diabetes: therapeutic considerations. The Lancet Diabetes and Endocrinology, 6(1), 60-68
Open this publication in new window or tab >>Aiding sleep in type 2 diabetes: therapeutic considerations
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2018 (English)In: The Lancet Diabetes and Endocrinology, ISSN 2213-8587, E-ISSN 2213-8595, Vol. 6, no 1, p. 60-68Article, review/survey (Refereed) Published
Abstract [en]

Insomnia and obstructive sleep apnoea (OSA) are more prevalent in patients with type 2 diabetes than in the general population. Both insomnia and OSA have been linked to cardiometabolic alterations (eg, hypertension, increased activity of the sympathetic nervous system, and systemic insulin resistance) that can exacerbate the pathophysiology of type 2 diabetes. Improvement of sleep in patients with diabetes could therefore aid the treatment of diabetes. To help health practitioners choose the best clinical tool to improve their patients' sleep without detrimentally affecting glucose regulation, this Review critically analyses the effects of common treatments for insomnia and OSA on both sleep and glucose metabolism in patients with type 2 diabetes. These treatments include pharmaceutical sleep aids (eg, benzodiazepine receptor agonists, melatonin) and cognitive behavioural therapy for insomnia, continuous positive airway pressure for OSA, and lifestyle interventions.

National Category
Endocrinology and Diabetes Pharmacology and Toxicology
Identifiers
urn:nbn:se:uu:diva-342756 (URN)10.1016/S2213-8587(17)30233-4 (DOI)000423799900020 ()28844889 (PubMedID)
Funder
Novo NordiskSwedish Research CouncilAFA InsuranceSwedish Society of MedicineThe Swedish Brain FoundationÅke Wiberg FoundationLars Hierta Memorial Foundation
Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-05-08Bibliographically approved
Tan, X. & Benedict, C. (2018). Association between high-glycemic diet and cerebral amyloid burden: a possible role for sleep [Letter to the editor]. American Journal of Clinical Nutrition, 107(3), 480-480
Open this publication in new window or tab >>Association between high-glycemic diet and cerebral amyloid burden: a possible role for sleep
2018 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 107, no 3, p. 480-480Article in journal, Letter (Other academic) Published
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:uu:diva-356236 (URN)10.1093/ajcn/nqx073 (DOI)000427882800018 ()29566198 (PubMedID)
Available from: 2018-07-27 Created: 2018-07-27 Last updated: 2018-07-27Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/000-0002-8911-4068

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