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Canto Moreira, Nuno
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Publications (10 of 14) Show all publications
Naseh, N., Gonzalez, K. E., Vaz, T., Ferreira, H., Kaul, Y. F., Johansson, M., . . . Hellström-Westas, L. (2017). Early Hyperglycemia And Brain MRI Findings In Very Preterm Infants. Acta Paediatrica, 106(SI 469), 16-16
Open this publication in new window or tab >>Early Hyperglycemia And Brain MRI Findings In Very Preterm Infants
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2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no SI 469, p. 16-16Article in journal, Meeting abstract (Other academic) Published
Abstract [en]

Objective: A previous study in extremely preterm infants demonstrated an association between hyperglycemia >8.3 mmol/l (150 mg/dl) on the first day of life and white matter reduction. The objectives of the present study were to further investigate possible associations between hyperglycemia and abnormal brain development and to evaluate the effect of hyperglycemia on neurodevelopment.

Method: Retrospective study of cerebral MRIs performed at term equivalent age in 75 very preterm infants (GA 22–31 weeks) born 2011–2015. The highest glucose values for each day, and the number of days with glucose >8.3 mmol/l during the first week of life were analyzed in relation to clinical data and MRI (1.5 T). The MRI evaluation included: visual scoring of gray and white matter abnormalities; measurement of apparent diffusion coefficient (ADC) in periventricular white matter, basal ganglia and pons, and a newly developed method for semi-automatic segmentation of brain volumes. MRI data were analyzed without knowledge of clinical data. No infant had IVH grade 3–4. No infant received insulin. Follow up at 2.5 years of corrected age is ongoing; data including Bayley Scales of Infant Development (BSID-III) was available in 45 infants.

Results: Clinical data are shown in the table. Significant (p < 0.05) univariate correlations were found between GA, BW, days on mechanical ventilation, highest blood glucose levels on days 2–5 and number of days with glucose >8.3 mmol/l, PVL and white matter volume. Days with glucose >8.3 mmol/l correlated independently with reduced white matter volume (p = 0.045), but not GA and days on mechanical ventilation. When BW was included in the analysis, days with glucose >8.3 mmol/l reached borderline significance (p = 0.068), but no other factor reached significance. For PVL, days of mechanical ventilation was the only independently associated factor (p = 0.012). In the 45 infants with follow up, only days with glucose >8.3 mmol/l was independently associated with a lower motor index on BSID-III.

Conclusion: Prolonged duration of high blood glucose >8.3 mmol/l during the first week of life in very preterm infants is associated with reduced white matter volume and may also be associated with poorer motor performance at 2.5 years.

National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-333331 (URN)10.1111/apa.13877/full (DOI)000405213500022 ()
Available from: 2017-11-15 Created: 2017-11-15 Last updated: 2017-11-15Bibliographically approved
Fragata, I., Alves, M., Papoila, A. L., Nunes, A. P., Ferreira, P., Canto-Moreira, N. & Canhao, P. (2017). Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage: Role of Diffusion Tensor Imaging. Stroke, 48(8), 2091-2097
Open this publication in new window or tab >>Early Prediction of Delayed Ischemia and Functional Outcome in Acute Subarachnoid Hemorrhage: Role of Diffusion Tensor Imaging
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2017 (English)In: Stroke, ISSN 0039-2499, E-ISSN 1524-4628, Vol. 48, no 8, p. 2091-2097Article in journal (Refereed) Published
Abstract [en]

Background and Purpose-Diffusion tensor imaging (DTI) parameters are markers of cerebral lesion in some diseases. In patients with acute subarachnoid hemorrhage (SAH), we investigated whether DTI parameters measured at < 72 hours might be associated with delayed cerebral ischemia (DCI) and with poor functional outcome at 3 months (modified Rankin Scale score =3).

Methods-DTI was performed in a prospective cohort of 60 patients with nontraumatic SAH at < 72 hours. Association of fractional anisotropy and apparent diffusion coefficient values at < 72 hours with the occurrence of DCI and outcome at 3 months was evaluated with logistic regression models, adjusting for known predictors of prognosis.

Results-At < 72 hours after SAH, fractional anisotropy values at the cerebellum were associated with DCI occurrence (78% less odds of DCI for each 0.1 increase in fractional anisotropy; P=0.019). Early apparent diffusion coefficient values were not associated with DCI. After adjusting for confounding variables, an increase of 10 U in apparent diffusion coefficient at the frontal centrum semiovale corresponded to 15% increased odds of poor outcome (P=0.061).

Conclusions-DTI parameters at < 72 hours post-SAH are independently associated with the occurrence of DCI and functional outcome. These preliminary results suggest the role of DTI parameters as surrogate markers of prognosis in nontraumatic SAH.

Keywords
anisotropy, cerebral ischemia, diffusion tensor imaging, prognosis, subarachnoid hemorrhage
National Category
Cardiac and Cardiovascular Systems Neurology
Identifiers
urn:nbn:se:uu:diva-332921 (URN)10.1161/STROKEAHA.117.016811 (DOI)000406128300034 ()28667021 (PubMedID)
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2017-11-16Bibliographically approved
Fragata, I., Canhão, P., Alves, M., Papoila, A. L. & Canto Moreira, N. (2017). Evolution of diffusion tensor imaging parameters after acute subarachnoid haemorrhage: a prospective cohort study. Neuroradiology, 59(1), 13-21
Open this publication in new window or tab >>Evolution of diffusion tensor imaging parameters after acute subarachnoid haemorrhage: a prospective cohort study
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2017 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 59, no 1, p. 13-21Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Few studies assessed diffusion tensor imaging (DTI) changes in the acute phase of subarachnoid haemorrhage (SAH). We prospectively evaluated DTI parameters in the acute phase of SAH and 8-10 days after and analysed whether changes could be related to SAH severity or to the development of delayed cerebral ischemia (DCI).

METHODS: Apparent diffusion coefficient (ADC) and fractional anisotropy (FA) changes over time were assessed in a prospective cohort of patients with acute SAH. Two MRI studies were performed at <72 h (MRI-1) and 8-10 days (MRI-2). DTI parameters were recorded in 15 ROIs. Linear mixed regression models were used.

RESULTS: Forty-two patients were included. Subtle changes in DTI parameters were found between MRI-1 and MRI-2. At the posterior limb of internal capsule (PLIC), a weak evidence of a 0.02 mean increase in FA (p = 0.064) and a 17.55 × 10(-6) mm(2)/s decrease in ADC (p = 0.052) were found in MRI-2. Both FA and ADC changed over time at the cerebellum (increase of 0.03; p = 0.017; decrease of 34.73 × 10(-6) mm(2)/s; p = 0.002, respectively). Patients with DCI had lower FA values on MRI-1 and lower ADC on MRI-2, although not reaching statistical significance, compared to non-DCI patients. DTI parameters on MRI-1 were not correlated to clinical admission scales.

CONCLUSION: ADC and FA values show subtle changes over time in acute SAH at the PLIC and cerebellum although not statistically associated with the severity of SAH or the occurrence of DCI. However, DTI changes occurred mainly in DCI patients, suggesting a possible role of DTI as a marker of DCI.

National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-315967 (URN)10.1007/s00234-016-1774-y (DOI)000392306400004 ()28028564 (PubMedID)
Available from: 2017-02-23 Created: 2017-02-23 Last updated: 2017-11-29Bibliographically approved
Ehrstedt, C., Canto Moreira, N., Casar Borota, O., Strömberg, B. & Ahlsten, G. (2017). Glioneuronal tumors in childhood - Before and after surgery. A long-term follow-up study. Epilepsy & Behavior, 72, 82-88
Open this publication in new window or tab >>Glioneuronal tumors in childhood - Before and after surgery. A long-term follow-up study
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2017 (English)In: Epilepsy & Behavior, ISSN 1525-5050, E-ISSN 1525-5069, Vol. 72, p. 82-88Article in journal (Refereed) Published
Abstract [en]

Aim: To give a detailed description of the long-term outcome of a cohort of children with glioneuronal tumors regarding pre-and postsurgical factors, including "dual" and "double" pathology, seizure freedom, and psychosocial outcome.

Methods: During a fifteen-year period (1995-2009), all patients (age 0-17.99 years) with a glioneuronal brain tumor diagnosed and treated at Uppsala University Children's Hospital were identified from the National Brain Tumor Registry and the National Epilepsy Surgery Registry. Hospital medical records were reviewed and neuroradiological and neuropathological findings were re-evaluated. A cross-sectional long-term follow-up prospective evaluation, including an interview, neurologic examination, and electroencephalogram, was accomplished in patients accepting participants in the study.

Results: A total of 25 out of 28 (89%) eligible patientswere included. The M: F ratiowas 1.5: 1. Mean follow-up time after surgery was 12.1 years (range 5.0-19.3). Twenty patients were adults (N18 years) at follow-up. Seizure freedomwas achieved in 64%. Gross total resection (GTR) was the only preoperative factor significantly correlating to seizure freedom (p= 0.027). Thirty-eight percent were at some time postoperatively admitted for a psychiatric evaluation. There was a trend towards both higher educational level and employment status in adults who became seizure free.

Conclusion: Long-termoutcome is good regarding seizure freedom if GTR can be achieved, but late seizure recurrence can occur. "Dual" and "double" pathology is uncommon and does not influence seizure outcome. Obtaining seizure freedomseems to be important for psychosocial outcome, but there is a risk for psychiatric comorbidities and long-term follow-up by a multi-professional team is advisable.

Place, publisher, year, edition, pages
ACADEMIC PRESS INC ELSEVIER SCIENCE, 2017
Keywords
Glioneuronal tumor, Childhood, "Dual" pathology, "Double" pathology, Seizure outcome, Psychosocial outcome
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-333399 (URN)10.1016/j.yebeh.2017.02.012 (DOI)000406321300015 ()28575773 (PubMedID)
Available from: 2017-11-16 Created: 2017-11-16 Last updated: 2017-11-16Bibliographically approved
Danfors, T., Velickaite, V. & Canto Moreira, N. (2016). The role of methionine positron emission tomography in the evaluation of central nervous system tumors in children. Paper presented at 27th International Symposium on Cerebral Blood Flow, Metabolism and Function / 12th International Conference on Quantification of Brain Function with PET, JUN 27-30, 2015, Vancouver, CANADA. Journal of Cerebral Blood Flow and Metabolism, 36(Suppl. 1), 394-395, Article ID 538.
Open this publication in new window or tab >>The role of methionine positron emission tomography in the evaluation of central nervous system tumors in children
2016 (English)In: Journal of Cerebral Blood Flow and Metabolism, ISSN 0271-678X, E-ISSN 1559-7016, Vol. 36, no Suppl. 1, p. 394-395, article id 538Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
SAGE PUBLICATIONS INC, 2016
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-321074 (URN)000394956300425 ()
Conference
27th International Symposium on Cerebral Blood Flow, Metabolism and Function / 12th International Conference on Quantification of Brain Function with PET, JUN 27-30, 2015, Vancouver, CANADA
Available from: 2017-05-05 Created: 2017-05-05 Last updated: 2017-05-05Bibliographically approved
Canto Moreira, N., Ribeiro, V., Teixeira, J., Raininko, R. & Wikstrom, J. (2013). Visualization of the Fetal Lip and Palate: Is Brain-Targeted MRI Reliable?. The Cleft Palate-Craniofacial Journal, 50(5), 513-519
Open this publication in new window or tab >>Visualization of the Fetal Lip and Palate: Is Brain-Targeted MRI Reliable?
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2013 (English)In: The Cleft Palate-Craniofacial Journal, ISSN 1055-6656, E-ISSN 1545-1569, Vol. 50, no 5, p. 513-519Article in journal (Refereed) Published
Abstract [en]

Objective : 

To evaluate the ability of brain-targeted magnetic resonance imaging (MRI) to assess the anatomy of the fetal upper lip and palate.

Design : 

Two independent readers made a blind retrospective review of 60 brain-targeted MRIs of fetuses from 20 to 38 gestational weeks (GW). Fifty-five MRIs were normal and five had orofacial anomalies, including one isolated cleft lip and four cleft lip and palate. Both normal and cleft MRIs had postnatal confirmation. The upper lip, primary palate, secondary palate, and nasal septum were scored into four levels, from evidently normal to evidently abnormal. In case of a suspected pathology, the readers attempted a diagnosis.

Setting :

Collaboration between a university hospital and a large private practice MRI center.

Results : 

Interobserver agreement (weighted kappa) was 0.79 for the upper lip, 0.70 for the primary palate, 0.86 for the secondary palate, and 0.90 for the nasal septum. The scoring levels of the readers did not change significantly across gestational age. Normality was correctly scored in 96% to 100% of the normal lips and primary palates and in 93% to 97% of the normal secondary palates depending on the reader. A deviated septum was only scored in two fetuses with unilateral cleft palates. The readers identified all pathological cases.

Conclusion :

Brain-targeted fetal MRI in experienced hands seems to be highly accurate for the evaluation of the lip and palate in fetuses above 20 GW, regardless of gestational age. The assessment of the secondary palate may be slightly more limited than the lip or primary palate.

National Category
Medical and Health Sciences Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-194154 (URN)10.1597/12-079 (DOI)000327536100005 ()23387935 (PubMedID)
Available from: 2013-02-11 Created: 2013-02-11 Last updated: 2017-12-06Bibliographically approved
Bajic, D., Canto Moreira, N., Wikström, J. & Raininko, R. (2012). Asymmetric Development of the Hippocampal Region Is Common: A Fetal MR Imaging Study. American Journal of Neuroradiology, 33(3), 513-518
Open this publication in new window or tab >>Asymmetric Development of the Hippocampal Region Is Common: A Fetal MR Imaging Study
2012 (English)In: American Journal of Neuroradiology, ISSN 0195-6108, E-ISSN 1936-959X, Vol. 33, no 3, p. 513-518Article in journal (Refereed) Published
Abstract [en]

BACKGROUND AND PURPOSE: Hippocampal development is poorly understood. This study evaluated the normal development of the hippocampal region during the fetal period by using MR imaging.

MATERIALS AND METHODS: MR images of 63 fetuses without intracranial pathology were reviewed independently by 2 radiologists with no knowledge of the fetal GA. Three MR images were performed postmortem and 60 in vivo. The progress of hippocampal inversion was analyzed in coronal sections, and the left and right sides of the hippocampal region were compared in every case.

RESULTS: The fetuses in the postmortem examinations were at GWs 17-18 and in the in vivo examinations, at GWs 19-36. The hippocampal sulcus was open, bi- or unilaterally, in 39 fetuses. The oldest was at GW 32. The sulcus was closed at GW 21 at the earliest, unilaterally. In 26/63 fetuses (41%), the deepening or closure of the hippocampal sulcus or hippocampal inversion was asymmetric; in 23 fetuses, the right side developed faster. A shallow collateral sulcus was found earliest at GW 17. A deep collateral sulcus was visible earliest at GW 26 unilaterally, but in all fetuses from GW 31 onward, it was seen bilaterally. The orientation of the collateral sulcus was not related to the GA.

CONCLUSIONS: There are wide individual temporal variations in the development and the inversion process of the hippocampal sulcus as well as in the formation of the collateral sulcus. Asymmetric development is common, and in most of the asymmetric cases, the right hippocampus develops faster.

National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
Radiology
Identifiers
urn:nbn:se:uu:diva-131994 (URN)10.3174/ajnr.A2814 (DOI)000301870300024 ()
Available from: 2010-10-12 Created: 2010-10-12 Last updated: 2017-12-12Bibliographically approved
Bajic, D., Canto Moreira, N., Wikström, J. & Raininko, R. (2011). Development of the hippocampal region demonstrated on fetal MRI: A preliminary report. NRJ Digital, 1(12), 555-557
Open this publication in new window or tab >>Development of the hippocampal region demonstrated on fetal MRI: A preliminary report
2011 (English)In: NRJ Digital, ISSN 2239-7493, Vol. 1, no 12, p. 555-557Article in journal (Refereed) Published
Abstract [en]

Coronal slices of three fetal MRIs performed post mortem and 37 performed in utero, all without intracranial pathology, was assessed. Progress of the hippocampal inversion was analyzed, the left and right sides were compared and occurrence of the collateral sulcus was revealed. The fetuses in the post mortem examinations were at gestation weeks (GW) 17-18 and in the in utero examinations at GW 19-35. The symmetric development of the hippocampal sulcus was revealed in 26 subjects and asymmetric in 14. The non-ovoid hippocampal formation could be evaluated at GW 24 at earliest and an ovoid hippocampus at GW 29. The collateral sulcus could be recognized at GW 17 in post mortem and at GW 22 in in utero examinations. From GW 29 onwards it was seen in all fetuses and it was symmetric in all but one case. Evaluation of the hippocampi is difficult on fetal MRI, especially in in utero examinations. The hippocampal development is not fulfilled at GW 21 as presumed. There is a wide temporal variation in the development of the hippocampal region, and the developmental process does not progress simultaneously in the right and left side of the same individual.

National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-170783 (URN)
Available from: 2012-03-13 Created: 2012-03-13 Last updated: 2012-03-13Bibliographically approved
Bajic, D., Canto Moreira, N., Wikström, J. & Raininko, R. (2011). Hippocampal development demonstrated by fetal MRI. Asymmetric development is common.. Paper presented at ECR 2011, Vienna, Austria. Insights into Imaging, 2(Suppl 1), B-831
Open this publication in new window or tab >>Hippocampal development demonstrated by fetal MRI. Asymmetric development is common.
2011 (English)In: Insights into Imaging, Vol. 2, no Suppl 1, p. B-831-Article in journal (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-246063 (URN)
Conference
ECR 2011, Vienna, Austria
Available from: 2015-03-02 Created: 2015-03-02 Last updated: 2015-03-25
Canto Moreira, N., Teixeira, J., Themudo, R., Amini, H., Axelsson, O., Raininko, R. & Wikström, J. (2011). Measurements of the normal fetal brain at gestation weeks 17 to 23: a MRI study. Neuroradiology, 53(1), 43-48
Open this publication in new window or tab >>Measurements of the normal fetal brain at gestation weeks 17 to 23: a MRI study
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2011 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 53, no 1, p. 43-48Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: To obtain measurements of the normal fetal brain before 24 weeks of gestation (GW), a deadline for medical decisions on fetal viability in a large number of countries. METHODS: We retrospectively reviewed 70 normal MR examinations of fetuses aged GW 17 to 23. The fronto-occipital diameter, the cerebral bi-parietal diameter, the transverse cerebellar diameter, the vermian height, and antero-posterior diameter were measured. RESULTS: The median, maximum, and minimum values for each parameter were displayed for each individual GW. CONCLUSION: The recorded data might contribute to a better assessment of fetal health by providing normal boundaries for the brain growth.

Keywords
Biometry, Brain, Fetal, MRI, Normal development
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-132616 (URN)10.1007/s00234-010-0772-8 (DOI)000285878200008 ()20878397 (PubMedID)
Available from: 2010-10-22 Created: 2010-10-22 Last updated: 2017-12-12Bibliographically approved
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