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Dabo, Fatimah
Publications (2 of 2) Show all publications
Dabo, F., Grönbladh, A., Nyberg, F., Sundström Poromaa, I. & Åkerud, H. (2010). Different SNP combinations in the GCH1 gene and use of labor analgesia. Molecular Pain, 6, 41
Open this publication in new window or tab >>Different SNP combinations in the GCH1 gene and use of labor analgesia
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2010 (English)In: Molecular Pain, E-ISSN 1744-8069, Vol. 6, p. 41-Article in journal (Refereed) Published
Abstract [en]

Background: The aim of this study was to investigate if there is an association between different SNP combinations in the guanosine triphosphate cyclohydrolase (GCH1) gene and a number of pain behavior related outcomes during labor. A population-based sample of pregnant women (n = 814) was recruited at gestational week 18. A plasma sample was collected from each subject. Genotyping was performed and three single nucleotide polymorphisms (SNP) previously defined as a pain-protective SNP combination of GCH1 were used. Results: Homozygous carriers of the pain-protective SNP combination of GCH1 arrived to the delivery ward with a more advanced stage of cervical dilation compared to heterozygous carriers and non-carriers. However, homozygous carriers more often used second line labor analgesia compared to the others. Conclusion: The pain-protective SNP combination of GCH1 may be of importance in the limited number of homozygous carriers during the initial dilation of cervix but upon arrival at the delivery unit these women are more inclined to use second line labor analgesia.

National Category
Medical and Health Sciences Pharmaceutical Sciences Biological Sciences
Identifiers
urn:nbn:se:uu:diva-134350 (URN)10.1186/1744-8069-6-41 (DOI)000282485300002 ()
Available from: 2010-11-25 Created: 2010-11-24 Last updated: 2023-09-21Bibliographically approved
Dabo, F., Nyberg, F., Zhou, Q., Sundström-Poromaa, I. & Åkerud, H. (2010). Plasma Levels of beta-Endorphin During Pregnancy and Use of Labor Analgesia. Reproductive Sciences, 17(8), 742-747
Open this publication in new window or tab >>Plasma Levels of beta-Endorphin During Pregnancy and Use of Labor Analgesia
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2010 (English)In: Reproductive Sciences, ISSN 1933-7191, Vol. 17, no 8, p. 742-747Article in journal (Refereed) Published
Abstract [en]

beta-endorphins are endogenous opioid substances produced by the pituitary gland and placenta. The aims of this project were to longitudinally follow plasma levels of beta-endorphin during pregnancy in women with a healthy pregnancy and to investigate whether plasma levels of beta-endorphin in late pregnancy are associated with need for additional pain medication beyond nitrous oxide during labor. Plasma samples from 45 women were collected at gestational weeks 10, 25, 28, 33 and 37, and beta-endorphin was analyzed by radioimmunoassay (RIA). Plasma levels of beta-endorphin displayed a significant decrease in gestational weeks 28 and 33 compared to week 10, followed by a subsequent increase between gestational weeks 28 and 37. However, there was no change in levels of beta-endorphin between gestational weeks 10 and 37. Low levels of beta-endorphin at the end of pregnancy were associated with need for additional pain medication beyond nitrous oxide during labor, although the causal relationship is unclear.

Keywords
Analgesia, beta-endorphin, labor, pain, pregnancy
National Category
Medical and Health Sciences Pharmaceutical Sciences
Identifiers
urn:nbn:se:uu:diva-136009 (URN)10.1177/1933719110370059 (DOI)000279408100006 ()
Available from: 2010-12-10 Created: 2010-12-09 Last updated: 2022-01-28Bibliographically approved
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