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Flachskampf, Frank
Alternative names
Publications (10 of 71) Show all publications
Katus, H., Ziegler, A., Ekinci, O., Giannitsis, E., Stough, W. G., Achenbach, S., . . . Semjonow, V. (2017). Early diagnosis of acute coronary syndrome. European Heart Journal, 38(41), 3049-3055.
Open this publication in new window or tab >>Early diagnosis of acute coronary syndrome
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2017 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 38, no 41, 3049-3055 p.Article, review/survey (Refereed) Published
Abstract [en]

The diagnostic evaluation of acute chest pain has been augmented in recent years by advances in the sensitivity and precision of cardiac troponin assays, new biomarkers, improvements in imaging modalities, and release of new clinical decision algorithms. This progress has enabled physicians to diagnose or rule-out acute myocardial infarction earlier after the initial patient presentation, usually in emergency department settings, which may facilitate prompt initiation of evidence-based treatments, investigation of alternative diagnoses for chest pain, or discharge, and permit better utilization of healthcare resources. A non-trivial proportion of patients fall in an indeterminate category according to rule-out algorithms, and minimal evidence-based guidance exists for the optimal evaluation, monitoring, and treatment of these patients. The Cardiovascular Round Table of the ESC proposes approaches for the optimal application of early strategies in clinical practice to improve patient care following the review of recent advances in the early diagnosis of acute coronary syndrome. The following specific 'indeterminate' patient categories were considered: (i) patients with symptoms and high-sensitivity cardiac troponin <99th percentile; (ii) patients with symptoms and high-sensitivity troponin <99th percentile but above the limit of detection; (iii) patients with symptoms and high-sensitivity troponin >99th percentile but without dynamic change; and (iv) patients with symptoms and high-sensitivity troponin >99th percentile and dynamic change but without coronary plaque rupture/erosion/dissection. Definitive evidence is currently lacking to manage these patients whose early diagnosis is 'indeterminate' and these areas of uncertainty should be assigned a high priority for research.

Keyword
Acute coronary syndrome, Troponin
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-333083 (URN)10.1093/eurheartj/ehx492 (DOI)29029109 (PubMedID)
Available from: 2017-11-06 Created: 2017-11-06 Last updated: 2017-11-23Bibliographically approved
Flachskampf, F. & Baron, T. (2017). Echocardiographic Algorithms for Detecting Elevated Diastolic Pressures Reasonable, Not Perfect. Journal of the American College of Cardiology, 69(15), 1949-1951.
Open this publication in new window or tab >>Echocardiographic Algorithms for Detecting Elevated Diastolic Pressures Reasonable, Not Perfect
2017 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 69, no 15, 1949-1951 p.Article in journal, Editorial material (Other academic) Published
Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 2017
Keyword
catheterization, diastole, Doppler, heart failure, net reclassification improvement
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-321547 (URN)10.1016/j.jacc.2017.02.022 (DOI)000398665500010 ()28408025 (PubMedID)
Available from: 2017-05-11 Created: 2017-05-11 Last updated: 2017-05-11Bibliographically approved
Baron, T., Orndahl, L. H., Kero, T., Sörensen, J., Bjerner, T., Hedin, E.-M., . . . Flachskampf, F. (2017). Volumetric quantification of regurgitant volume in asymptomatic severe degenerative mitral regurgitation by echocardiography and cardiac mri with independent validation of forward stroke volume by positron emission tomography. Paper presented at 66th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), MAR 17-19, 2017, Washington, DC. Journal of the American College of Cardiology, 69(11 Suppl), 1973-1973.
Open this publication in new window or tab >>Volumetric quantification of regurgitant volume in asymptomatic severe degenerative mitral regurgitation by echocardiography and cardiac mri with independent validation of forward stroke volume by positron emission tomography
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2017 (English)In: Journal of the American College of Cardiology, ISSN 0735-1097, E-ISSN 1558-3597, Vol. 69, no 11 Suppl, 1973-1973 p.Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
ELSEVIER SCIENCE INC, 2017
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-321054 (URN)10.1016/S0735-1097(17)35362-7 (DOI)000397342302695 ()
Conference
66th Annual Scientific Session and Expo of the American-College-of-Cardiology (ACC), MAR 17-19, 2017, Washington, DC
Available from: 2017-05-05 Created: 2017-05-05 Last updated: 2017-05-05Bibliographically approved
Baron, T., Örndahl, L. H., Kero, T., Sörensen, J., Bjerner, T., Hedin, E.-M., . . . Flachskampf, F. A. (2016). Comparison of left ventricular volumes and regurgitant volumes by echocardiography and magnetic resonance in patients with severe degenerative mitral regurgitation. Paper presented at Congress of the European-Society-of-Cardiology (ESC), AUG 27-31, 2016, Rome, ITALY. European Heart Journal, 37, 1239-1239.
Open this publication in new window or tab >>Comparison of left ventricular volumes and regurgitant volumes by echocardiography and magnetic resonance in patients with severe degenerative mitral regurgitation
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2016 (English)In: European Heart Journal, ISSN 0195-668X, E-ISSN 1522-9645, Vol. 37, 1239-1239 p.Article in journal, Meeting abstract (Refereed) Published
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-313883 (URN)000383869506148 ()
Conference
Congress of the European-Society-of-Cardiology (ESC), AUG 27-31, 2016, Rome, ITALY
Available from: 2017-01-25 Created: 2017-01-25 Last updated: 2017-11-29Bibliographically approved
Flachskampf, F. A., Biering-Sorensen, T., Solomon, S. D., Duvernoy, O., Bjerner, T. & Smiseth, O. A. (2016). Heart Rate Is an Important Consideration for Cardiac Imaging of Diastolic Function Reply [Letter to the editor]. JACC Cardiovascular Imaging, 9(6), 758-759.
Open this publication in new window or tab >>Heart Rate Is an Important Consideration for Cardiac Imaging of Diastolic Function Reply
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2016 (English)In: JACC Cardiovascular Imaging, ISSN 1936-878X, E-ISSN 1876-7591, Vol. 9, no 6, 758-759 p.Article in journal, Letter (Refereed) Published
National Category
Cardiac and Cardiovascular Systems Obstetrics, Gynecology and Reproductive Medicine
Identifiers
urn:nbn:se:uu:diva-299974 (URN)10.1016/j.jcmg.2015.11.015 (DOI)000377418700022 ()26897672 (PubMedID)
Available from: 2016-08-01 Created: 2016-08-01 Last updated: 2017-11-28Bibliographically approved
Flachskampf, F. A. (2016). How Exactly Do You Measure That Aorta?: Lessons From Multimodality Imaging. JACC Cardiovascular Imaging, 9(3), 227-229.
Open this publication in new window or tab >>How Exactly Do You Measure That Aorta?: Lessons From Multimodality Imaging
2016 (English)In: JACC Cardiovascular Imaging, ISSN 1936-878X, E-ISSN 1876-7591, Vol. 9, no 3, 227-229 p.Article in journal, Editorial material (Other academic) Published
Keyword
aorta, computed tomography, echocardiography, magnetic resonance
National Category
Radiology, Nuclear Medicine and Medical Imaging Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-299005 (URN)10.1016/j.jcmg.2015.07.017 (DOI)000372455400002 ()26897693 (PubMedID)
Note

Comment on: The Need for Standardized Methods for Measuring the Aorta: Multimodality Core Lab Experience From the GenTAC Registry. [JACC Cardiovasc Imaging. 2016]

Available from: 2016-07-13 Created: 2016-07-13 Last updated: 2017-11-28Bibliographically approved
Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F. ., Dokainish, H., Edvardsen, T., . . . Waggoner, A. D. (2016). Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. European Heart Journal Cardiovascular Imaging, 17(12), 1321-1360.
Open this publication in new window or tab >>Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging
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2016 (English)In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 17, no 12, 1321-1360 p.Article in journal (Refereed) Published
Keyword
diastole, echocardiography, doppler, heart failure
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-316972 (URN)10.1093/ehjci/jew082 (DOI)000393059300001 ()27422899 (PubMedID)
Available from: 2017-03-08 Created: 2017-03-08 Last updated: 2017-11-29Bibliographically approved
Nagueh, S. F., Smiseth, O. A., Appleton, C. P., Byrd, B. F. ., Dokainish, H., Edvardsen, T., . . . Waggoner, A. D. (2016). Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging. Journal of the American Society of Echocardiography, 29(4), 277-314.
Open this publication in new window or tab >>Recommendations for the Evaluation of Left Ventricular Diastolic Function by Echocardiography: An Update from the American Society of Echocardiography and the European Association of Cardiovascular Imaging
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2016 (English)In: Journal of the American Society of Echocardiography, ISSN 0894-7317, E-ISSN 1097-6795, Vol. 29, no 4, 277-314 p.Article in journal (Refereed) Published
Keyword
Diastole, Echocardiography, Doppler, Heart failure
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-295557 (URN)10.1016/j.echo.2016.01.011 (DOI)000373609700002 ()27037982 (PubMedID)
Available from: 2016-06-22 Created: 2016-06-08 Last updated: 2017-11-28Bibliographically approved
Baron, T. & Flachskampf, F. A. (2016). Simultaneous 4-Chamber Strain More and Faster Analysis, But Is It Good Enough?. Circulation Cardiovascular Imaging, 9(3), Article ID e004544.
Open this publication in new window or tab >>Simultaneous 4-Chamber Strain More and Faster Analysis, But Is It Good Enough?
2016 (English)In: Circulation Cardiovascular Imaging, ISSN 1941-9651, E-ISSN 1942-0080, Vol. 9, no 3, e004544Article in journal, Editorial material (Other academic) Published
Keyword
Editorials, cardiovascular imaging, deformation, longitudinal strain, strain
National Category
Cardiac and Cardiovascular Systems Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-298953 (URN)10.1161/CIRCIMAGING.116.004544 (DOI)000371982700001 ()26926270 (PubMedID)
Available from: 2016-07-13 Created: 2016-07-12 Last updated: 2017-11-28Bibliographically approved
Baron, T., Flachskampf, F. A., Johansson, K., Hedin, E.-M. & Christersson, C. (2016). Usefulness of traditional echocardiographic parameters in assessment of left ventricular function in patients with normal ejection fraction early after acute myocardial infarction: results from a large consecutive cohort. European Heart Journal Cardiovascular Imaging, 17(4), 413-420.
Open this publication in new window or tab >>Usefulness of traditional echocardiographic parameters in assessment of left ventricular function in patients with normal ejection fraction early after acute myocardial infarction: results from a large consecutive cohort
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2016 (English)In: European Heart Journal Cardiovascular Imaging, ISSN 2047-2404, E-ISSN 2047-2412, Vol. 17, no 4, 413-420 p.Article in journal (Refereed) Published
Abstract [en]

AIMS: The aim of this study was to assess the frequency of left ventricular (LV) systolic function impairment using classical echocardiographic parameters and their relation to myocardial damage in patients hospitalized for acute myocardial infarction (MI) with normal LV ejection fraction (LVEF ≥52% in males or ≥54% in females).

METHODS AND RESULTS: All 421 consecutive patients with MI included in the REBUS (RElevance of Biomarkers for future risk of thromboembolic events in UnSelected post-myocardial infarction patients) study underwent two-dimensional and Doppler echocardiography within 72 h after admission. A normal LVEF was present in 262 (73.8%) of the 355 patients ultimately enrolled in the study. Patients with normal LVEF more often presented with non-ST-elevation myocardial infarction and had less comorbidities when compared with those with impaired LVEF. No differences in demographic factors or relevant medications were observed. Higher value of mean annular plane systolic excursion (MAPSE), lower wall motion score index (WMSI), lower LV as well as left atrial volumes characterized patients with normal LVEF. Impaired MAPSE was present in 64.4%, WMSI >1 in 72.1%, and dilated left atrium in 33.6% of those patients. Maximal cardiac troponin concentration reflecting infarct size showed the strongest association with WMSI (β = 0.35), followed by LVEF (β = -0.29), MAPSE (β = -0.25), and indexed LV end-systolic volume (β = 0.19; P < 0.001 for all the models).

CONCLUSION: In two-third of patients with MI and normal LVEF, at least one of the other markers of systolic function was outside of the normal range. WMSI reflected the size of MI better than global LV function parameters as LVEF or MAPSE.

National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-265869 (URN)10.1093/ehjci/jev160 (DOI)000375440800012 ()26139362 (PubMedID)
Available from: 2015-12-04 Created: 2015-11-03 Last updated: 2017-12-01Bibliographically approved
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