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Low, Aili
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Publications (5 of 5) Show all publications
Lindahl, A. E., Low, A., Stridsberg, M., Sjöberg, F., Ekselius, L. & Gerdin, B. (2013). Plasma chromogranin A after severe burn trauma. Neuropeptides, 47(3), 207-212
Open this publication in new window or tab >>Plasma chromogranin A after severe burn trauma
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2013 (English)In: Neuropeptides, ISSN 0143-4179, E-ISSN 1532-2785, Vol. 47, no 3, p. 207-212Article in journal (Refereed) Published
Abstract [en]

BACKGROUND:

Chromogranin A (CgA) in plasma (P-CgA), a neuroendocrine marker of sympathetic stress, has been shown to predict mortality in medical intensive care. We hypothesized that the magnitude of CgA release would reflect stress load, and thereby injury severity in burn intensive care patients.

METHODS:

Fifty-one consecutive patients with a burn area exceeding 10% were included. P-CgA was measured twice daily for seven days after injury. The point value at 24h, the mean and maximum values and the AUC at days 1-7, were tested as possible predictors. Injury severity in the form of organ dysfunction was measured as SOFA score at day 7.

RESULTS:

P-CgA could be classified into two types with respect to variability over time. Patients with high variability had more deep injuries and were older than those with low variability. All measures of CgA correlated with SOFA score at day 7, but not with total burn size. Univariate regressions showed that age, burn size and three of four measures of P-CgA predicted organ dysfunction. Multiple regressions showed that age, burn size, and either P-CgA at 24h, the mean value up to day 7, or the maximum value up to day 7, were independent predictors for organ dysfunction. Significant organ dysfunction was best predicted by age, burn area and the CgA point value at 24h with an AUC value of 0.91 in a ROC-analysis.

CONCLUSIONS:

The extent of neuroendocrine activation assessed as P-CgA after a major burn injury is independently related to organ dysfunction.

National Category
Clinical Medicine
Identifiers
urn:nbn:se:uu:diva-188785 (URN)10.1016/j.npep.2012.10.004 (DOI)000320751200010 ()23206950 (PubMedID)
Available from: 2012-12-19 Created: 2012-12-19 Last updated: 2017-12-06Bibliographically approved
Low, A., Meyer, W. J., Willebrand, M. & Thomas, C. R. (2012). Psychiatric Disorders Associated with Burn Injury (4th eded.). In: Total Burn Care: (pp. 733-741). Elsevier
Open this publication in new window or tab >>Psychiatric Disorders Associated with Burn Injury
2012 (English)In: Total Burn Care, Elsevier, 2012, 4th ed, p. 733-741Chapter in book (Refereed)
Place, publisher, year, edition, pages
Elsevier, 2012 Edition: 4th ed
National Category
Psychiatry Surgery
Identifiers
urn:nbn:se:uu:diva-274194 (URN)10.1016/B978-1-4377-2786-9.00065-5 (DOI)978-1-4377-2786-9 (ISBN)
Available from: 2016-01-20 Created: 2016-01-20 Last updated: 2017-09-07Bibliographically approved
Low, A. J. F., Dyster-Aas, J., Willebrand, M., Ekselius, L. & Gerdin, B. (2012). Psychiatric morbidity predicts perceived burn-specific health 1 year after a burn. General Hospital Psychiatry, 34(2), 146-152
Open this publication in new window or tab >>Psychiatric morbidity predicts perceived burn-specific health 1 year after a burn
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2012 (English)In: General Hospital Psychiatry, ISSN 0163-8343, E-ISSN 1873-7714, Vol. 34, no 2, p. 146-152Article in journal (Refereed) Published
Abstract [en]

Objective:

Individual factors such as gender, age, coping and personality traits and injury-related factors such as injury severity have been implicated as risk factors for poor perceived health after burns. As psychiatric morbidity is common in individuals who sustain burns, the aim of this study was to examine the effect of preinjury psychiatric problems on perceived health after injury.

Method:

A total of 85 consecutive patients treated at a national burn center were prospectively assessed: the patients were interviewed during acute care with the Structured Clinical Interview for DSM-IV Axis I Disorders. One year after injury, perceived health was assessed with the Bum-Specific Health Scale-Brief (BSHS-B). Multiple regression analyses were used to evaluate the predictive effect of preinjury psychiatric history on perceived postinjury health.

Results:

Psychiatric morbidity, especially mood disorders, affected outcome for six of the nine BSHS-B subscales, with the covariates mainly being the length of hospital stay and total burn size.

Conclusion:

The results show that a history of preinjury psychiatric disorders, especially during the year before the burn, affects perceived outcome regarding both physical and psychological aspects of health 1 year after injury and that it is a risk factor for worse perceived outcome.

Keywords
Psychiatric morbidity, Health, Prediction, Trauma, Burn
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-172038 (URN)10.1016/j.genhosppsych.2011.12.001 (DOI)000301022100006 ()
Available from: 2012-04-02 Created: 2012-04-01 Last updated: 2017-12-07Bibliographically approved
Willebrand, M., Low, A., Dyster-Aas, J., Kildal, M., Andersson, G., Ekselius, L. & Gerdin, B. (2004). Pruritus, personality traits and coping in long-term follow-up of burn-injured patients. Acta Dermato-Venereologica, 84(5), 375-80
Open this publication in new window or tab >>Pruritus, personality traits and coping in long-term follow-up of burn-injured patients
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2004 (English)In: Acta Dermato-Venereologica, ISSN 0001-5555, E-ISSN 1651-2057, Vol. 84, no 5, p. 375-80Article in journal (Other academic) Published
Abstract [en]

Pruritus is a major problem after burn injury; however, prevalence and predictors of prolonged pruritus are not known. The aims were to assess frequency of pruritus and the role of personality traits and coping in prolonged pruritus. The participants were burn patients injured 1-18 years earlier (n=248). Pruritus was assessed with an item from the Abbreviated Burn Specific Health Scale, personality was assessed with the Swedish universities Scales of Personality, and coping with the Coping with Burns Questionnaire. In all, 60% of the participants had pruritus at follow-up, however as the time after injury increased, the number of patients with persistent itch decreased. In logistic regression, 39% of the likelihood of having persistent pruritus was explained by greater extent of burn, less time after injury, and psychological features (being less assertive, and using more instrumental but less emotional support). In summary, chronic burn-related pruritus is rather common and psychological factors such as anxiety-related traits and coping are significantly associated with its presence.

Keywords
Adaptation; Psychological, Anxiety/*psychology, Burns/*complications/psychology, Chronic Disease, Follow-Up Studies, Humans, Personality, Pruritus/etiology/*psychology
National Category
Surgery
Identifiers
urn:nbn:se:uu:diva-14542 (URN)10.1080/00015550410032941 (DOI)15370704 (PubMedID)
Available from: 2008-01-30 Created: 2008-01-30 Last updated: 2017-12-11Bibliographically approved
Low, A., Dyster Aas, J., Willebrand, M., Kildal, M., Gerdin, B. & Ekselius, L. (2003). Chronic nightmares after severe burns; risk factors and implications for treatment.. J Burn Care Rehabil, 24, 260
Open this publication in new window or tab >>Chronic nightmares after severe burns; risk factors and implications for treatment.
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2003 (English)In: J Burn Care Rehabil, Vol. 24, p. 260-Article in journal (Refereed) Published
Keywords
Adult, Aged, Aged; 80 and over, Biological Markers/analysis, Biopsy; Needle, Case-Control Studies, Colitis; Ulcerative/*metabolism/*pathology, Collagen, Colonoscopy/*methods, Comparative Study, Female, Fibroblast Growth Factor 2/*analysis, Humans, Immunohistochemistry, Intestinal Mucosa/pathology/*secretion, Male, Middle Aged, Perfusion, Probability, Prognosis, Reference Values, Research Support; Non-U.S. Gov't, Sensitivity and Specificity, Severity of Illness Index, Statistics; Nonparametric
Identifiers
urn:nbn:se:uu:diva-64889 (URN)
Available from: 2006-12-20 Created: 2006-12-20 Last updated: 2011-01-13
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