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Wyöni, Per-Ivan
Publications (10 of 11) Show all publications
Engelmark, M., Ivansson, E., Magnusson, J., Gustavsson, I., Wyöni, P.-I., Ingman, M., . . . Gyllensten, U. (2008). Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis. Human Genetics, 123(5), 437-443
Open this publication in new window or tab >>Polymorphisms in 9q32 and TSCOT are linked to cervical cancer in affected sib-pairs with high mean age at diagnosis
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2008 (English)In: Human Genetics, ISSN 0340-6717, E-ISSN 1432-1203, Vol. 123, no 5, p. 437-443Article in journal (Refereed) Published
Abstract [en]

Cervical cancer is a multifactorial disease influenced by both environmental and genetic factors. We have previously found linkage to 9q32 in a genomewide scan of affected sib-pairs (ASPs) with cervical cancer and to the thymic stromal co-transporter (TSCOT), a candidate gene in this region. Here we examined the contribution of 9q32 and TSCOT to cervical cancer susceptibility using at larger material of 641 ASPs, 278 of which were included in the earlier genome-scan. Since heritable forms of cancer frequently show stronger genetic effects in families with early onset of disease, we stratified the ASPs into two groups based on mean age at diagnosis (MAAD) within sib-pairs. Surprisingly, ASPs with high MAAD (30.5-47.5 years) showed increased sharing at all microsatellite markers at 9q31.1-33.1 and linkage signals of up to MLS = 2.74 for TSCOT SNPs, while ASPs with low MAAD (19-30 years) showed no deviation from random genetic sharing (MLS = 0.00). The difference in allelic sharing between the two MAAD strata was significant (P < 0.005) and is not likely to be explained by the HLA haplotype, a previously known genetic susceptibility factor for cervical cancer. Our results indicate locus heterogeneity in the susceptibility to cervical cancer between the two strata, with polymorphisms in the 9q32 region mainly showing an effect in women with high MAAD.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-16120 (URN)10.1007/s00439-008-0494-8 (DOI)000256080600002 ()18392855 (PubMedID)
Available from: 2008-05-22 Created: 2008-05-22 Last updated: 2017-12-08Bibliographically approved
Emahazion, T., Jobs, M., Howell, M., Siegfried, M., Wyöni, P.-I., Prince, J. & Brookes, A. (1999). Identification of 167 Polymorphisms in 88 Genes from Candidate Neurodegeneration Pathways. Gene, 238(2), 315-324
Open this publication in new window or tab >>Identification of 167 Polymorphisms in 88 Genes from Candidate Neurodegeneration Pathways
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1999 (English)In: Gene, ISSN 0378-1119, E-ISSN 1879-0038, Vol. 238, no 2, p. 315-324Article in journal (Refereed) Published
Abstract [en]

Catalogs of intra-gene polymorphisms are needed to facilitate wide-ranging candidate gene-based association studies in common complex diseases. With this in mind, we have scanned multiple alignments of expressed sequence tags and of genomic DNA sequences (PCR products from four to eight unrelated individuals) to find polymorphisms in 195 genes putatively involved in neurodegenerative illness (including components of oxidative stress, excitotoxicity, inflammation, apoptosis and aging). This led to the discovery of 167 polymorphisms in 88 genes. These comprised 163 single nucleotide polymorphisms, one insertion/deletion, and three other variations involving more than one base pair. The polymorphisms were distributed in the exons (87), introns (70), and gene flanking regions (10). Of the exonic polymorphisms, 17 would give rise to non-synonymous amino acid substitutions. These findings now provide a valuable resource for association studies in neurodegenerative disorders such as Alzheimer's disease and Parkinson's disease.

National Category
Medical Genetics
Identifiers
urn:nbn:se:uu:diva-51356 (URN)10.1016/S0378-1119(99)00330-3 (DOI)
Available from: 2008-10-17 Created: 2008-10-17 Last updated: 2018-01-11Bibliographically approved
Jansson, H., Wyöni, P.-I., Fernholm, B., Bredwad, M., Mierzykowska, A. & Tegelström, H. (1995). Genetic relationships among species of hagfish revealed by protein electrophoresis. Journal of Fish Biology, 47(4), 599-608
Open this publication in new window or tab >>Genetic relationships among species of hagfish revealed by protein electrophoresis
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1995 (English)In: Journal of Fish Biology, ISSN 0022-1112, E-ISSN 1095-8649, Vol. 47, no 4, p. 599-608Article in journal (Refereed) Published
Abstract [en]

Hagfish species of the genera Myxine, Eptatretus and Pnramyxine were analysed for genetic variation by allozyme electrophoresis and isoelectric focusing of general proteins. Large genetic differences were observed between samples of supposed conspecifics of Myxine circifrons from off the Californian coast, and also within one sample of Paramyxine sp. from Sagami Bay, Japan. The results are convincing evidence of the existence of additional sympatric species in these two areas. In general, the highest genetic identities were found between species within the subfamilies Myxininae and Eptatretinae. Within Eptatretinae, the Japanese species Eptatietus burgeri was genetically more similar to Japanese species of Paramyxine than to American species of Eptatretus. Thus, our data indicate that the generic status of Paramyxine should be reconsidered. (C) 1995 The Fisheries Society of the British Isles.

National Category
Zoology
Research subject
Biology with specialization in Systematics
Identifiers
urn:nbn:se:uu:diva-251925 (URN)10.1111/j.1095-8649.1995.tb01926.x (DOI)A1995TC95600005 ()
Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2017-12-04
Sjögren, P. & Wyöni, P.-I. (1994). Conservation Genetics and Detection of Rare Alleles in Finite Populations. Conservation Biology, 8(1), 267-270
Open this publication in new window or tab >>Conservation Genetics and Detection of Rare Alleles in Finite Populations
1994 (English)In: Conservation Biology, ISSN 0888-8892, E-ISSN 1523-1739, Vol. 8, no 1, p. 267-270Article in journal (Refereed) Published
National Category
Genetics
Research subject
Biology with specialization in Population Biology; Biology with specialization in Evolutionary Genetics
Identifiers
urn:nbn:se:uu:diva-251865 (URN)10.1046/j.1523-1739.1994.08010267.x (DOI)A1994NC66200031 ()
Available from: 2015-04-24 Created: 2015-04-24 Last updated: 2017-12-04
Tegelström, H., Wyöni, P.-I., Gelter, H. & Jaarola, M. (1988). Concordant divergence in proteins and mitochondrial DNA between two vole species in the genus Clethrionomys. Biochemical Genetics, 26(3-4), 223-237
Open this publication in new window or tab >>Concordant divergence in proteins and mitochondrial DNA between two vole species in the genus Clethrionomys
1988 (English)In: Biochemical Genetics, ISSN 0006-2928, E-ISSN 1573-4927, Vol. 26, no 3-4, p. 223-237Article in journal (Refereed) Published
National Category
Evolutionary Biology
Research subject
Biology with specialization in Evolutionary Genetics
Identifiers
urn:nbn:se:uu:diva-251903 (URN)10.1007/BF00561462 (DOI)A1988N620600004 ()3044353 (PubMedID)
Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2017-12-04
Tegelström, H. & Wyöni, P.-I. (1986). Fixation of polyacrylamide gels to supporting glass plates. Trends in Genetics, 2(12), 306-306
Open this publication in new window or tab >>Fixation of polyacrylamide gels to supporting glass plates
1986 (English)In: Trends in Genetics, ISSN 0168-9525, E-ISSN 1362-4555, Vol. 2, no 12, p. 306-306Article in journal (Refereed) Published
National Category
Biochemistry and Molecular Biology
Research subject
Biology with specialization in Molecular Biology
Identifiers
urn:nbn:se:uu:diva-251904 (URN)10.1016/0168-9525(86)90284-2 (DOI)A1986F418000007 ()
Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2017-12-04
Tegelström, H. & Wyöni, P.-I. (1986). Silanization of supporting glass plates avoiding fixation of polyacrylamide gels to glass cover plates. Electrophoresis, 7(2), 99-99
Open this publication in new window or tab >>Silanization of supporting glass plates avoiding fixation of polyacrylamide gels to glass cover plates
1986 (English)In: Electrophoresis, ISSN 0173-0835, E-ISSN 1522-2683, Vol. 7, no 2, p. 99-99Article in journal (Refereed) Published
National Category
Biochemistry and Molecular Biology
Research subject
Biochemistry
Identifiers
urn:nbn:se:uu:diva-251905 (URN)10.1002/elps.1150070209 (DOI)A1986A520800008 ()
Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2017-12-04
Tegelström, H., Nilsson, G. & Wyöni, P.-I. (1983). Lack of species differences in isoelectric focused proteins in the Formica rufa group (Hymenoptera, Formicidae). Hereditas, 98(2), 161-165
Open this publication in new window or tab >>Lack of species differences in isoelectric focused proteins in the Formica rufa group (Hymenoptera, Formicidae)
1983 (English)In: Hereditas, ISSN 0018-0661, E-ISSN 1601-5223, Vol. 98, no 2, p. 161-165Article in journal (Refereed) Published
National Category
Zoology
Research subject
Biology with specialization in Systematics
Identifiers
urn:nbn:se:uu:diva-251906 (URN)10.1111/j.1601-5223.1983.tb00590.x (DOI)A1983QT24500001 ()6874388 (PubMedID)
Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2017-12-04
Wyöni, P.-I., Tegelström, H. & Ryttman, H. (1982). Genetic Divergence Among Bird Species Assessed by Using Isoelectric Focusing (IEF). Hereditas, 97(2), 333-333
Open this publication in new window or tab >>Genetic Divergence Among Bird Species Assessed by Using Isoelectric Focusing (IEF)
1982 (English)In: Hereditas, ISSN 0018-0661, E-ISSN 1601-5223, Vol. 97, no 2, p. 333-333Article in journal (Refereed) Published
National Category
Zoology
Research subject
Biology with specialization in Systematics
Identifiers
urn:nbn:se:uu:diva-251908 (URN)A1982PU27600069 ()
Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2017-12-04
Tegelström, H., Wyöni, P.-I. & Ryttman, H. (1982). Thin-layer Isoelectric Focusing as a Tool for Higher Category Systematics. Annales Zoologici Fennici, 19(3), 203-207
Open this publication in new window or tab >>Thin-layer Isoelectric Focusing as a Tool for Higher Category Systematics
1982 (English)In: Annales Zoologici Fennici, ISSN 0003-455X, E-ISSN 1797-2450, Vol. 19, no 3, p. 203-207Article in journal (Refereed) Published
National Category
Zoology
Research subject
Biology with specialization in Systematics
Identifiers
urn:nbn:se:uu:diva-251907 (URN)A1982PW31600009 ()
Available from: 2015-04-27 Created: 2015-04-27 Last updated: 2017-12-04
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