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Sundelöf, Lars-Olof
Publications (2 of 2) Show all publications
Sundelöf, L.-O. (2009). AIR AND FIRE Carl Wilhelm Scheele, Torbern Bergman, The Royal Society of Sciences and the Discovery of Oxygen in Uppsala in the year 1772. In: OXYGEN TRANSPORT TO TISSUE XXX: . Paper presented at 35th Annual Conference of the International-Society-on-Oxygen-Transport-to-Tissue, 2007, Uppsala, SWEDEN (pp. 1-6).
Open this publication in new window or tab >>AIR AND FIRE Carl Wilhelm Scheele, Torbern Bergman, The Royal Society of Sciences and the Discovery of Oxygen in Uppsala in the year 1772
2009 (English)In: OXYGEN TRANSPORT TO TISSUE XXX, 2009, p. 1-6Conference paper, Published paper (Refereed)
Series
Advances in Experimental Medicine and Biology, ISSN 0065-2598 ; 645
National Category
Medicinal Chemistry
Identifiers
urn:nbn:se:uu:diva-260041 (URN)10.1007/978-0-387-85998-9_1 (DOI)000262627100001 ()19227442 (PubMedID)978-0-387-85997-2 (ISBN)
Conference
35th Annual Conference of the International-Society-on-Oxygen-Transport-to-Tissue, 2007, Uppsala, SWEDEN
Available from: 2015-08-14 Created: 2015-08-14 Last updated: 2018-01-11Bibliographically approved
Persson, A. M., Baumann, K., Sundelöf, L.-O., Lindberg, W., Sokolowski, A. & Pettersson, C. (2008). Design and Characterization of a New Miniaturized Rotating Disk Equipment for In Vitro Dissolution Rate Studies. Journal of Pharmaceutical Sciences, 97(8), 3344-3355
Open this publication in new window or tab >>Design and Characterization of a New Miniaturized Rotating Disk Equipment for In Vitro Dissolution Rate Studies
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2008 (English)In: Journal of Pharmaceutical Sciences, ISSN 0022-3549, E-ISSN 1520-6017, Vol. 97, no 8, p. 3344-3355Article in journal (Refereed) Published
Abstract [en]

A miniaturized apparatus for the determination of the apparent in vitro dissolution rate has been designed, constructed and characterized. The miniaturized apparatus was based on a low volume dissolution cell and a disk in a rotating magnetic bar. The disk tablet is pressed directly into the bar with a press designed and constructed for this purpose. It requires approximately 5 mg of substance. The disk was positioned eccentrically on the bar with an external flow of medium to increase the rate of solvent flow over the disk surface. Six different drug substances were used. The dissolution media were sodium phosphate buffer, pH 7.0, and ammonium acetate buffer, pH 6.8. All quantifications were made by integrating the dissolution cell with high-performance liquid chromatography (HPLC) using diode-array detection (DAD). The obtained results were compared with data from a conventional rotating disk equipment, where the disk was centrically mounted. The dissolution rates at 100 rpm seemed to be on an average of 2-3 times higher for the miniaturized apparatus (RSD 0.2-56%). The preliminary studies of this prototype indicate that the miniaturized rotating disk is a promising design for the qualitative estimation of dissolution rates of substances, for example during screening in early drug discovery.

Place, publisher, year, edition, pages
Wiley InterScience, 2008
Keywords
dissolution rate, in vitro models, physicochemical properties; analytical chemistry, HPLC (high-performance/pressure liquid chromatography), miniaturization
National Category
Medicinal Chemistry Medicinal Chemistry
Research subject
Analytical Pharmaceutical Chemistry
Identifiers
urn:nbn:se:uu:diva-17637 (URN)10.1002/jps.21235 (DOI)000258081100034 ()
Available from: 2010-01-11 Created: 2009-10-08 Last updated: 2018-01-12Bibliographically approved
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