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El-Shabasy, R., Yosri, N., El-Seedi, H., Shoueir, K. & El-Kemary, M. (2019). A green synthetic approach using chili plant supported Ag/Ag2O@P25 heterostructure with enhanced photocatalytic properties under solar irradiation. Optik (Stuttgart), 192, Article ID 162943.
Open this publication in new window or tab >>A green synthetic approach using chili plant supported Ag/Ag2O@P25 heterostructure with enhanced photocatalytic properties under solar irradiation
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2019 (English)In: Optik (Stuttgart), ISSN 0030-4026, E-ISSN 1618-1336, Vol. 192, article id 162943Article in journal (Refereed) Published
Abstract [en]

As the environmental pollution is a global, catastrophic occurrence, green synthesis of different catalysts has long been pursued. Herein, Capsicum annuum L (chili) extract-based catalysts were used for the fabrication of Ag/Ag2O nanoparticles (NPs) without harsh conditions. The prepared Ag/Ag2O NPs were uniform with an average size of 11.4 nm. The Ag/Ag2O was smoothly coupled with P25 to produce Ag/Ag2O@P25 photocatalyst which had effective electron-hole pair separation and active sites for high photocatalytic activity. The catalyst degraded 98.7% of the model pollutant methylene blue (MB) and catalytic conversion of 100% 2,4-dinitroaniline (2,4-DNA) within 60 s were realized under energy saving solar-light illumination, matching the rules of "green chemistry". In addition, the prepared photocatalyst exhibited superior stability and reusability, and the hot filtration test proved the heterogeneity of the catalyst.

Keywords
Green synthesis, Ag/Ag2O nanoparticles, Heterostructure, Photocatalysis, Uv/visible-light
National Category
Other Chemistry Topics
Identifiers
urn:nbn:se:uu:diva-397677 (URN)10.1016/j.ijleo.2019.162943 (DOI)000494471400031 ()
Available from: 2019-11-28 Created: 2019-11-28 Last updated: 2019-11-28Bibliographically approved
Chen, L., Gnanaraj, C., Arulselvan, P., El-Seedi, H. & Teng, H. (2019). A review on advanced microencapsulation technology to enhance bioavailability of phenolic compounds: Based on its activity in the treatment of Type 2 Diabetes. Trends in Food Science & Technology, 85, 149-162
Open this publication in new window or tab >>A review on advanced microencapsulation technology to enhance bioavailability of phenolic compounds: Based on its activity in the treatment of Type 2 Diabetes
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2019 (English)In: Trends in Food Science & Technology, ISSN 0924-2244, E-ISSN 1879-3053, Vol. 85, p. 149-162Article, review/survey (Refereed) Published
Abstract [en]

Background: Studies on and the application of polyphenolic compounds, have recently attracted great interest in the functional foods due to their potential health benefits to humans. However, the major disadvantage associated with phenolic compounds is their constrained bioavailability, mainly caused by its low aqueous solubility, poor stability and limited membrane permeability.

Scope and approach: The aim of this study is to give an overview of the microencapsulation technology to enhance bioavailability of phenolic compounds. Furthermore, the anti-diabetic effect of microencapsulated phenolic compounds and capability of them to produce new functional foods will be discussed.

Key findings and conclusions: The utilization of microencapsulated polyphenols, instead of free compounds, can effectively alleviate the deficiencies. This review provided valuable insight that may be useful for identifying trends in the commercialization of microencapsulation -technological products or for identifying new research areas. The results published to date confirm that the encapsulation promotes the protection of active compounds, enabling industrial applications of active packaging.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE LONDON, 2019
Keywords
Phenolics, Metabolites, Type 2 diabetes, Insulin resistance, Bioavailability
National Category
Food Science
Identifiers
urn:nbn:se:uu:diva-380670 (URN)10.1016/j.tifs.2018.11.026 (DOI)000460715700014 ()
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01Bibliographically approved
Zahra, M. H., Salem, T. A. R., El-Aarag, B., Yosri, N., EL-Ghlban, S., Zaki, K., . . . El-Seedi, H. (2019). Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities. Molecules, 24(13), Article ID 2495.
Open this publication in new window or tab >>Alpinia zerumbet (Pers.): Food and Medicinal Plant with Potential In Vitro and In Vivo Anti-Cancer Activities
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2019 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 24, no 13, article id 2495Article in journal (Refereed) Published
Abstract [en]

Background/Aim: Plants play an important role in anti-cancer drug discovery, therefore, the current study aimed to evaluate the biological activity of Alpinia zerumbet (A. zerumbet) flowers.

Methods: The phytochemical and biological criteria of A. zerumbet were in vitro investigated as well as in mouse xenograft model.

Results: A. zerumbet extracts, specially CH2Cl2 and MeOH extracts, exhibited the highest potent anti-tumor activity against Ehrlich ascites carcinoma (EAC) cells. The most active CH2Cl2 extract was subjected to bioassay-guided fractionation leading to isolatation of the naturally occurring 5,6-dehydrokawain (DK) which was characterized by IR, MS, H-1-NMR and C-13-NMR. A. zerumbet extracts, specially MeOH and CH2Cl2 extracts, exhibited significant inhibitory activity towards tumor volume (TV). Furthermore, A. zerumbet extracts declined the high level of malonaldehyde (MDA) as well as elevated the levels of superoxide dismutase (SOD) and catalase (CAT) in liver tissue homogenate. Moreover, DK showed anti-proliferative action on different human cancer cell lines. The recorded IC50 values against breast carcinoma (MCF-7), liver carcinoma (Hep-G2) and larynx carcinoma cells (HEP-2) were 3.08, 6.8, and 8.7 mu g/mL, respectively.

Conclusion: Taken together, these findings open the door for further investigations in order to explore the potential medicinal properties of A. zerumbet.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
Alpinia zerumbet, 5, 6-dehydrokawain, Ehrlich ascites carcinoma, anti-tumor, anti-oxidant
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-392590 (URN)10.3390/molecules24132495 (DOI)000476700300149 ()31288458 (PubMedID)
Funder
Swedish Research Council, 2016-05885
Available from: 2019-09-06 Created: 2019-09-06 Last updated: 2019-09-06Bibliographically approved
Hussain, A., Oves, M., Alajmi, M. F., Hussain, I., Amir, S., Ahmed, J., . . . Ali, I. (2019). Biogenesis of ZnO nanoparticles using Pandanus odorifer leaf extract: anticancer and antimicrobial activities. RSC Advances, 9(27), 15357-15369
Open this publication in new window or tab >>Biogenesis of ZnO nanoparticles using Pandanus odorifer leaf extract: anticancer and antimicrobial activities
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2019 (English)In: RSC Advances, ISSN 2046-2069, E-ISSN 2046-2069, Vol. 9, no 27, p. 15357-15369Article in journal (Refereed) Published
Abstract [en]

The continuously increasing incidence rates of cancer and infectious diseases are open threats to the sustainable survival of animals and humans. In the last two decades, the demands of nanomaterials as modern therapeutic agents have increased. In this study, biogenic zinc oxide nanoparticles (ZnO NPs) were developed from aqueous Pandanus odorifer leaf extract (POLE) and characterized using modern methods and tools, such as electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy (EDX), Fourier transform infrared spectroscopy and UV-vis spectroscopy, which indicated the formation of very pure, spherical NPs approximately 90 nm in size. The anticancer activity of the ZnO NPs was evaluated by MTT and neutral red uptake (NRU) assays in MCF-7, HepG2 and A-549 cells at different doses (1, 2, 5, 10, 25, 50, 100 g ml(-1)). Moreover, the morphology of the treated cancer cells was examined by phase contrast microscopy. The results suggest that the synthesized ZnO NPs inhibited the growth of the cells when applied a concentration from 50-100 g ml(-1). Moreover, the biogenic ZnO NPs were analysed as an antimicrobial agent against pathogenic bacteria. The highest antibacterial activity was observed against Gram-positive Bacillus subtilis (26 nm) and Gram-negative Escherichia coli (24 mm) at 50 g per well. Complete bacterial growth (100%) vanished 100% upon treatment with ZnO NPs at 85 g ml(-1). Overall, POLE mediated derived biogenic ZnO NPs could serve as a significant anticancer and antimicrobial agent and be used in the development of novel drugs and skin care products.

Place, publisher, year, edition, pages
ROYAL SOC CHEMISTRY, 2019
National Category
Other Chemistry Topics
Identifiers
urn:nbn:se:uu:diva-387958 (URN)10.1039/c9ra01659g (DOI)000470161800030 ()
Available from: 2019-06-27 Created: 2019-06-27 Last updated: 2019-06-27Bibliographically approved
Efferth, T., Banerjee, M., Abu-Darwish, M. S., Abdelfatah, S., Böckers, M., Bhakta-Guha, D., . . . Paul, N. W. (2019). Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts. Phytomedicine, 53, 319-331
Open this publication in new window or tab >>Biopiracy versus One-World Medicine-From colonial relicts to global collaborative concepts
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2019 (English)In: Phytomedicine, ISSN 0944-7113, E-ISSN 1618-095X, Vol. 53, p. 319-331Article, review/survey (Refereed) Published
Abstract [en]

Background: Practices of biopiracy to use genetic resources and indigenous knowledge by Western companies without benefit-sharing of those, who generated the traditional knowledge, can be understood as form of neo-colonialism. Hypothesis: The One-World Medicine concept attempts to merge the best of traditional medicine from developing countries and conventional Western medicine for the sake of patients around the globe. Study design: Based on literature searches in several databases, a concept paper has been written. Legislative initiatives of the United Nations culminated in the Nagoya protocol aim to protect traditional knowledge and regulate benefit-sharing with indigenous communities. The European community adopted the Nagoya protocol, and the corresponding regulations will be implemented into national legislation among the member states. Despite pleasing progress, infrastructural problems of the health care systems in developing countries still remain. Current approaches to secure primary health care offer only fragmentary solutions at best. Conventional medicine from industrialized countries cannot be afforded by the impoverished population in the Third World. Confronted with exploding costs, even health systems in Western countries are endangered to burst. Complementary and alternative medicine (CAM) is popular among the general public in industrialized countries, although the efficacy is not sufficiently proven according to the standards of evidence-based medicine. CAM is often available without prescription as over-the-counter products with non-calculated risks concerning erroneous self-medication and safety/toxicity issues. The concept of integrative medicine attempts to combine holistic CAM approaches with evidence-based principles of conventional medicine. Conclusion: To realize the concept of One-World Medicine, a number of standards have to be set to assure safety, efficacy and applicability of traditional medicine, e.g. sustainable production and quality control of herbal products, performance of placebo-controlled, double-blind, randomized clinical trials, phytovigilance, as well as education of health professionals and patients.

Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Complementary and alternative medicine, Evidence-based medicine, Integrative medicine, Nagoya protocol, Quality control, Traditional medicine
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-379422 (URN)10.1016/j.phymed.2018.06.007 (DOI)000459935700036 ()30190231 (PubMedID)
Funder
German Research Foundation (DFG), DFG/GRK 2015/1
Available from: 2019-03-19 Created: 2019-03-19 Last updated: 2019-03-19Bibliographically approved
El-Seedi, H. R., Khalifa, S. A. M., Taher, E. A., Farag, M. A., Saeed, A., Gamal, M., . . . Efferth, T. (2019). Cardenolides: Insights from chemical structure and pharmacological utility. Pharmacological Research, 141, 123-175
Open this publication in new window or tab >>Cardenolides: Insights from chemical structure and pharmacological utility
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2019 (English)In: Pharmacological Research, ISSN 1043-6618, E-ISSN 1096-1186, Vol. 141, p. 123-175Article, review/survey (Refereed) Published
Abstract [en]

Cardiac glycosides (CGs) are a class of naturally occurring steroid-like compounds, and members of this class have been in clinical use for more than 1500 years. They have been used in folk medicine as arrow poisons, abortifacients, heart tonics, emetics, and diuretics as well as in other applications. The major use of CGs today is based on their ability to inhibit the membrane-bound Na+/K+ -ATPase enzyme, and they are regarded as an effective treatment for congestive heart failure (CHF), cardiac arrhythmia and atrial fibrillation. Furthermore, increasing evidence has indicated the potential cytotoxic effects of CGs against various types of cancer. In this review, we highlight some of the structural features of this class of natural products that are crucial for their efficacy, some methods of isolating these compounds from natural resources, and the structural elucidation tools that have been used. We also describe their physicochemical properties and several modern biotechnological approaches for preparing CGs that do not require plant sources.

Keywords
Cardiac glycosides, Chemical property space, Isolation, Heart failure
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:uu:diva-380669 (URN)10.1016/j.phrs.2018.12.015 (DOI)000460997000011 ()30579976 (PubMedID)
Funder
Swedish Research Council, 2016-05908
Available from: 2019-04-01 Created: 2019-04-01 Last updated: 2019-04-01Bibliographically approved
Aneja, B., Khan, N. S., Khan, P., Queen, A., Hussain, A., Rehman, M. T. T., . . . Abid, M. (2019). Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis. European Journal of Medicinal Chemistry, 163, 840-852
Open this publication in new window or tab >>Design and development of Isatin-triazole hydrazones as potential inhibitors of microtubule affinity-regulating kinase 4 for the therapeutic management of cell proliferation and metastasis
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2019 (English)In: European Journal of Medicinal Chemistry, ISSN 0223-5234, E-ISSN 1768-3254, Vol. 163, p. 840-852Article in journal (Refereed) Published
Abstract [en]

Microtubule affinity-regulating kinase 4 (MARK4) is a potential drug target as the same is found to be over expressed in several types of cancers. In search of effective MARK4 inhibitors, we have synthesized and characterized Isatin-triazole hydrazones (9a-i) and evaluated their inhibitory potential. Of all the compounds, 9g showed better binding affinity and enzyme inhibition potential in sub micromolar range. Human serum albumin (HSA) binding assay suggested an easy transportation of 9g in blood stream due to its binding affinity. In vitro anticancer studies performed on MCF-7, MDA-MB-435s and HepG2 cells using 9g showed inhibition of cell proliferation and cell migration. Further, 9g induces apoptosis in these cancerous cells, with IC50 values of 6.22, 9.94 and 8.14 mu M, respectively. Putatively, 9g seems to cause oxidative stress resulting in apoptosis. Functional assay of 9g with a panel of 26 kinases showed MARK4 specific profile. In conclusion, 9g seems to possess an effective inhibitory potential towards MARK4 adding an additional repertoire to anticancer therapeutics.

Keywords
Microtubule affinity-regulating kinase 4, Isatin-triazole hydrazones, Cell proliferation, Oxidative stress, Apoptosis, Metastasis
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:uu:diva-378190 (URN)10.1016/j.ejmech.2018.12.026 (DOI)000458597300061 ()30579124 (PubMedID)
Available from: 2019-03-04 Created: 2019-03-04 Last updated: 2019-03-04Bibliographically approved
Ujan, R., Saeed, A., Channar, P. A., Larik, F. A., Abbas, Q., Alajmi, M. F., . . . Seo, S.-Y. (2019). Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation. Molecules, 24(5), Article ID 860.
Open this publication in new window or tab >>Drug-1,3,4-Thiadiazole Conjugates as Novel Mixed-Type Inhibitors of Acetylcholinesterase: Synthesis, Molecular Docking, Pharmacokinetics, and ADMET Evaluation
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2019 (English)In: Molecules, ISSN 1420-3049, E-ISSN 1420-3049, Vol. 24, no 5, article id 860Article in journal (Refereed) Published
Abstract [en]

A small library of new drug-1,3,4-thiazidazole hybrid compounds (3a-3i) was synthesized, characterized, and assessed for their acetyl cholinesterase enzyme (AChE) inhibitory and free radical scavenging activities. The newly synthesized derivatives showed promising activities against AChE, especially compound 3b (IC50 18.1 +/- 0.9 nM), which was the most promising molecule in the series, and was substantially more active than the reference drug (neostigmine methyl sulfate; IC50 2186.5 +/- 98.0 nM). Kinetic studies were performed to elucidate the mode of inhibition of the enzyme, and the compounds showed mixed-type mechanisms for inhibiting AChE. The Ki of 3b (0.0031 mu M) indicates that it can be very effective, even at low concentrations. Compounds 3a-3i all complied with Lipinski's Rule of Five, and showed high drug-likeness scores. The pharmacokinetic parameters revealed notable lead-like properties with insignificant liver and skin-penetrating effects. The structure-activity relationship (SAR) analysis indicated pi-pi interactions with key amino acid residues related to Tyr124, Trp286, and Tyr341.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
mixed-type AChE inhibitors, ADMET parameters, pharmacokinetics, drug-likeness, synthesis, antioxidant activity, molecular docking, 1, 3, 4-thiadiazole-drug
National Category
Pharmacology and Toxicology Medicinal Chemistry
Identifiers
urn:nbn:se:uu:diva-382471 (URN)10.3390/molecules24050860 (DOI)000462662900036 ()30823444 (PubMedID)
Available from: 2019-05-02 Created: 2019-05-02 Last updated: 2019-05-02Bibliographically approved
Amir, M., Kumar, V., Dohare, R., Rehman, M. T. T., Hussain, A., Alajmi, M. F., . . . Hassan, M. I. I. (2019). Investigating architecture and structure-function relationships in cold shock DNA-binding domain family using structural genomics-based approach. International Journal of Biological Macromolecules, 133, 484-494
Open this publication in new window or tab >>Investigating architecture and structure-function relationships in cold shock DNA-binding domain family using structural genomics-based approach
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2019 (English)In: International Journal of Biological Macromolecules, ISSN 0141-8130, E-ISSN 1879-0003, Vol. 133, p. 484-494Article in journal (Refereed) Published
Abstract [en]

Oligonucleotide/oligosaccharide-binding fold (OB-fold) plays a major role in the regulation of central dogma of life via binding though DNA and RNA. The OB-fold domains are diverse in nature and present in large number of proteins with verities of molecular functions. Here, we have investigated the distribution of sequence, structure and repeats of cold shock DNA-binding proteins (CSDB), a member of OB-fold, in all three kingdoms to establish functional relationships. The CSDB is consists of 30 domains with a major contribution of S1 (>110,601 sequences), S12 (>23,760 sequences), S17 (>14,833 sequences) and S28e (>1615 sequence) domains. These domains are largely found in bacteria (70-90%). The number of S1 domain repeats in eukaryota varies from 1 to 15 and are well-correlated with the protein size. The molecular function analysis suggests that a large number of repeats in the S1 domain are involved in diverse molecular functions in bacteria and eukaryotes. In-depth structure analysis of Si, S12, S17 and S28e domain-containing proteins of the OB-fold family provides a reasonable basis to understand the relationship of size and number of repeats with the corresponding molecular functions.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2019
Keywords
OB-fold, Nucleic acid-binding superfamily, Cold shock DNA-binding proteins, RNA-binding proteins, Structural genomics, Molecular evolution
National Category
Biochemistry and Molecular Biology
Identifiers
urn:nbn:se:uu:diva-390782 (URN)10.1016/j.ijbiomac.2019.04.135 (DOI)000472685700053 ()31005689 (PubMedID)
Available from: 2019-08-16 Created: 2019-08-16 Last updated: 2019-08-16Bibliographically approved
Khalifa, S. A. M., Elias, N., Farag, M. A., Chen, L., Saeed, A., Hegazy, M.-E. F., . . . El-Seedi, H. (2019). Marine Natural Products: A Source of Novel Anticancer Drugs. Marine Drugs, 17(9), Article ID 491.
Open this publication in new window or tab >>Marine Natural Products: A Source of Novel Anticancer Drugs
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2019 (English)In: Marine Drugs, ISSN 1660-3397, E-ISSN 1660-3397, Vol. 17, no 9, article id 491Article, review/survey (Refereed) Published
Abstract [en]

Cancer remains one of the most lethal diseases worldwide. There is an urgent need for new drugs with novel modes of action and thus considerable research has been conducted for new anticancer drugs from natural sources, especially plants, microbes and marine organisms. Marine populations represent reservoirs of novel bioactive metabolites with diverse groups of chemical structures. This review highlights the impact of marine organisms, with particular emphasis on marine plants, algae, bacteria, actinomycetes, fungi, sponges and soft corals. Anti-cancer effects of marine natural products in in vitro and in vivo studies were first introduced; their activity in the prevention of tumor formation and the related compound-induced apoptosis and cytotoxicities were tackled. The possible molecular mechanisms behind the biological effects are also presented. The review highlights the diversity of marine organisms, novel chemical structures, and chemical property space. Finally, therapeutic strategies and the present use of marine-derived components, its future direction and limitations are discussed.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
marine, plants, microorganism, antitumor, anticancer, cytotoxic, clinical trials, drugs
National Category
Pharmacology and Toxicology
Identifiers
urn:nbn:se:uu:diva-395919 (URN)10.3390/md17090491 (DOI)000487959700017 ()31443597 (PubMedID)
Funder
Swedish Research Council, 2016-05885
Available from: 2019-10-30 Created: 2019-10-30 Last updated: 2019-10-30Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-2519-6690

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