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Finnsson, Johannes
Publications (8 of 8) Show all publications
Finnsson, J., Lubberink, M., Savitcheva, I., Fällmar, D., Melberg, A., Kumlien, E. & Raininko, R. (2019). Glucose metabolism in the brain in LMNB1-related autosomal dominant leukodystrophy.. Acta Neurologica Scandinavica, 139(2), 135-142
Open this publication in new window or tab >>Glucose metabolism in the brain in LMNB1-related autosomal dominant leukodystrophy.
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2019 (English)In: Acta Neurologica Scandinavica, ISSN 0001-6314, E-ISSN 1600-0404, Vol. 139, no 2, p. 135-142Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: LMNB1-related autosomal dominant leukodystrophy is caused by an overexpression of the protein lamin B1, usually due to a duplication of the LMNB1 gene. Symptoms start in 5th to 6th decade. This slowly progressive disease terminates with death. We studied brain glucose metabolism in this disease using 18 F-fluorodeoxyglucose positron emission tomography (PET).

METHODS: We examined 8 patients, aged 48-64 years, in varying stages of clinical symptomatology. Two patients were investigated with quantitative PET on clinical indications after which six more patients were recruited. Absolute glucose metabolism was analyzed with the PVElab software in 6 patients and 18 healthy controls. A semiquantitative analysis using the CortexID software was performed in seven investigations, relating local metabolism levels to global glucose metabolism.

RESULTS: The clinical quantitative PET revealed low global glucose metabolism, with the most marked reduction in the cerebellum. In the PVElab analysis, patients presented low mean glucose metabolism in the cerebellum, brainstem and global grey matter. In the semiquantitative analysis, 2 patients showed a decreased metabolism in the cerebellum and 4 patients a relatively higher metabolism in parts of the temporal lobes. Since none of the patients showed an increased metabolism in the quantitative analysis, we interpret these increases as "pseudo-increases" related to a globally reduced metabolism.

CONCLUSIONS: Global reduction of grey matter glucose metabolism in this white matter disease most likely depends on a combination of cortical afferent dysfunction and, in later stages, neuronal loss. The lowest metabolism in the cerebellum is consistent with histopathological findings and prominent cerebellar symptoms.

Keywords
18F-fluorodeoxyglucose, adult-onset leukodystrophy, autosomal dominant leukodystrophy, glucose metabolism, positron emission tomography
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-362200 (URN)10.1111/ane.13024 (DOI)000454813600005 ()30192380 (PubMedID)
Available from: 2018-10-02 Created: 2018-10-02 Last updated: 2019-01-30Bibliographically approved
Finnsson, J., Sundblom, J., Dahl, N., Melberg, A. & Raininko, R. (2015). LMNB1-related autosomal-dominant leukodystrophy: Clinical and radiological course. Annals of Neurology, 78(3), 412-25
Open this publication in new window or tab >>LMNB1-related autosomal-dominant leukodystrophy: Clinical and radiological course
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2015 (English)In: Annals of Neurology, ISSN 0364-5134, E-ISSN 1531-8249, Vol. 78, no 3, p. 412-25Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Duplication of the LMNB1 gene encoding lamin B1 causes adult-onset autosomal-dominant leukodystrophy (ADLD) starting with autonomic symptoms, which are followed by pyramidal signs and ataxia. Magnetic resonance imaging (MRI) of the brain reveals characteristic findings. This is the first longitudinal study on this disease. Our objective is to describe the natural clinical and radiological course of LMNB1-related ADLD.

METHODS: Twenty-three subjects in two families with LMNB1 duplications were studied over two decades with clinical assessment and MRI of the brain and spinal cord. They were 29 to 70 years old at their first MRI. Repeated MRIs were performed in 14 subjects over a time period of up to 17 years.

RESULTS: Pathological MRI findings were found in the brain and spinal cord in all examinations (i.e., even preceding clinical symptoms). MRI changes and clinical symptoms progressed in a definite order. Autonomic dysfunction appeared in the fifth to sixth decade, preceding or together with gait and coordination difficulties. Motor signs developed ascending from spastic paraplegia to tetraplegia and pseudobulbar palsy in the seventh decade. There were clinical, radiological, and neurophysiological signs of myelopathy. Survival lasted more than two decades after clinical onset.

INTERPRETATION: LMNB1-related ADLD is a slowly progressive neurological disease. MRI abnormalities of the brain and spinal cord can precede clinical symptoms by more than a decade and are extensive in all symptomatic patients. Spinal cord involvement is a likely contributing factor to early autonomic symptoms and spastic paraplegia. Ann Neurol 2015;78:412-425.

National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-261207 (URN)10.1002/ana.24452 (DOI)000360218800008 ()26053668 (PubMedID)
Note

Atle Melberg och Raili Raininko delar sistaförfattarskapet.

Available from: 2015-08-31 Created: 2015-08-31 Last updated: 2018-01-11Bibliographically approved
Finnsson, J., Sundblom, J., Melberg, A. & Raininko, R. (2014). O151-Longitudinal MRI Study of the Spinal Cord in Lamin B1 Autosomal Dominant Leukodystrophy: Do the first symptoms come from the spinal cord?. Paper presented at XXth Symposium Neuroradiologicum, 7-12 September, 2014, Istanbul, Turkey.. Neuroradiology, 56(Suppl 1), S246
Open this publication in new window or tab >>O151-Longitudinal MRI Study of the Spinal Cord in Lamin B1 Autosomal Dominant Leukodystrophy: Do the first symptoms come from the spinal cord?
2014 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 56, no Suppl 1, p. S246-Article in journal, Meeting abstract (Refereed) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-246089 (URN)10.1007/s00234-014-1405-4 (DOI)
Conference
XXth Symposium Neuroradiologicum, 7-12 September, 2014, Istanbul, Turkey.
Available from: 2015-03-02 Created: 2015-03-02 Last updated: 2017-12-04Bibliographically approved
Finnsson, J., Melberg, A. & Raininko, R. (2013). 1H-MR spectroscopy of adult-onset autosomal dominant leukodystrophy with autonomic symptoms. Neuroradiology, 55(8), 933-939
Open this publication in new window or tab >>1H-MR spectroscopy of adult-onset autosomal dominant leukodystrophy with autonomic symptoms
2013 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 55, no 8, p. 933-939Article in journal (Refereed) Published
Abstract [en]

Adult-onset ADLD with autonomic symptoms is a rare disease with a clinical course somewhat similar to chronic progressive MS but with different imaging findings consisting of extensive white matter changes in the cerebrum and cerebellar peduncles. Patients usually present in the fourth to sixth decade with autonomic symptoms, manifesting later symptoms from the pyramidal tracts and ataxia. Here, we present magnetic resonance spectroscopy (MRS) findings in this disease. Fourteen subjects, from two non-related families, with genetic linkage to the disease were studied with magnetic resonance imaging and single-voxel MRS. Clinically, they ranged from asymptomatic to wheelchair-using. Their results were compared to those of age- and sex-matched healthy controls. One MRS was excluded due to suboptimal quality. The remaining 13 subjects manifested characteristic evidence of pathology on MRI, 11 of them exhibited extensive changes. The metabolite concentrations of total Cr, total Cho, and total NAA measured in millimolars, using internal water as a reference, were significantly lower in these 11 subjects compared to controls, and we found linear correlations between all these metabolite levels. When total Cr was used as a reference, we found no difference between subjects and controls. No lactate was detected. The decreased metabolite concentrations measured using internal water as a reference are most likely due to increased water content in the tissues, diluting all metabolites to a similar degree. This is also in agreement with the high signal intensity exhibited in the white matter on T2-weighted MR images and with the reported histopathological findings of vacuolated myelin.

National Category
Neurology
Research subject
Neurology
Identifiers
urn:nbn:se:uu:diva-204429 (URN)10.1007/s00234-013-1174-5 (DOI)000322020900002 ()23636437 (PubMedID)
Available from: 2013-08-05 Created: 2013-08-05 Last updated: 2017-12-06Bibliographically approved
Finnsson, J., Savitcheva, I., Lubberink, M., Melberg, A. & Raininko, R. (2013). Glucose metabolism in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms. Paper presented at 37th Annual Meeting of European Society of Neuroradiology, September 28 - October 1, 2013, Frankfurt, Germany.. Neuroradiology, 55(Suppl1), S36, Article ID S.18.06.
Open this publication in new window or tab >>Glucose metabolism in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms
Show others...
2013 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 55, no Suppl1, p. S36-, article id S.18.06Article in journal, Meeting abstract (Refereed) Published
National Category
Clinical Medicine
Identifiers
urn:nbn:se:uu:diva-246076 (URN)10.1007/s00234-013-1236-8 (DOI)
Conference
37th Annual Meeting of European Society of Neuroradiology, September 28 - October 1, 2013, Frankfurt, Germany.
Available from: 2015-03-02 Created: 2015-03-02 Last updated: 2017-12-04Bibliographically approved
Finnsson, J., Melberg, A. & Raininko, R. (2012). 1H-MR spectroscopy only shows elevated water content in adult onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms. Paper presented at 16th Congress of the European-Federation-of-Neurological-Societies (EFNS), SEP 08-11, 2012, Stockholm, SWEDEN. European Journal of Neurology, 19(S1), 401-401
Open this publication in new window or tab >>1H-MR spectroscopy only shows elevated water content in adult onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms
2012 (English)In: European Journal of Neurology, ISSN 1351-5101, E-ISSN 1468-1331, Vol. 19, no S1, p. 401-401Article in journal, Meeting abstract (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-184732 (URN)000309359702172 ()
Conference
16th Congress of the European-Federation-of-Neurological-Societies (EFNS), SEP 08-11, 2012, Stockholm, SWEDEN
Available from: 2012-11-15 Created: 2012-11-13 Last updated: 2017-12-07Bibliographically approved
Finnsson, J., Melberg, A. & Raininko, R. (2012). MRI and clinical  follow-up in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms. Paper presented at The 36th Annual Meeting of European Society of Neuroradiology, 21st-23rd September, 2012, Edinburgh, United Kingdom.. Neuroradiology, 54(Suppl1), S61, Article ID O1A-3.7.
Open this publication in new window or tab >>MRI and clinical  follow-up in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms
2012 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 54, no Suppl1, p. S61-, article id O1A-3.7Article in journal, Meeting abstract (Refereed) Published
National Category
Clinical Medicine
Identifiers
urn:nbn:se:uu:diva-246074 (URN)10.1007/s00234-012-1062-4 (DOI)
Conference
The 36th Annual Meeting of European Society of Neuroradiology, 21st-23rd September, 2012, Edinburgh, United Kingdom.
Available from: 2015-03-02 Created: 2015-03-02 Last updated: 2017-12-04Bibliographically approved
Finnsson, J., Raininko, R. & Melberg, A. (2011). Proton MR spectroscopy of supraventricular white matter in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms. Paper presented at The 35th Annual Meeting of European Society of Neuroradiology, Friday, September 23rd, 2011, Antwerp, Belgium.. Neuroradiology, 53(Suppl 1), S50-S51
Open this publication in new window or tab >>Proton MR spectroscopy of supraventricular white matter in adult-onset autosomal dominant leukodystrophy (ADLD) with autonomic symptoms
2011 (English)In: Neuroradiology, ISSN 0028-3940, E-ISSN 1432-1920, Vol. 53, no Suppl 1, p. S50-S51Article in journal, Meeting abstract (Refereed) Published
National Category
Clinical Medicine
Identifiers
urn:nbn:se:uu:diva-246068 (URN)10.1007/s00234-011-0914-7 (DOI)
Conference
The 35th Annual Meeting of European Society of Neuroradiology, Friday, September 23rd, 2011, Antwerp, Belgium.
Available from: 2015-03-02 Created: 2015-03-02 Last updated: 2017-12-04Bibliographically approved
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