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2023 (English)In: Psychosomatic Medicine, ISSN 0033-3174, E-ISSN 1534-7796, Vol. 85, no 2, p. 188-202Article in journal (Refereed) Published
Abstract [en]
ObjectiveType D personality, a joint tendency toward negative affectivity and social inhibition, has been linked to adverse events in patients with heart disease, although with inconsistent findings. Here, we apply an individual patient-data meta-analysis to data from 19 prospective cohort studies (N = 11,151) to investigate the prediction of adverse outcomes by type D personality in patients with acquired cardiovascular disease.MethodFor each outcome (all-cause mortality, cardiac mortality, myocardial infarction, coronary artery bypass grafting, percutaneous coronary intervention, major adverse cardiac event, any adverse event), we estimated type D's prognostic influence and the moderation by age, sex, and disease type.ResultsIn patients with cardiovascular disease, evidence for a type D effect in terms of the Bayes factor (BF) was strong for major adverse cardiac event (BF = 42.5; odds ratio [OR] = 1.14) and any adverse event (BF = 129.4; OR = 1.15). Evidence for the null hypothesis was found for all-cause mortality (BF = 45.9; OR = 1.03), cardiac mortality (BF = 23.7; OR = 0.99), and myocardial infarction (BF = 16.9; OR = 1.12), suggesting that type D had no effect on these outcomes. This evidence was similar in the subset of patients with coronary artery disease (CAD), but inconclusive for patients with heart failure (HF). Positive effects were found for negative affectivity on cardiac and all-cause mortality, with the latter being more pronounced in male than female patients.ConclusionAcross 19 prospective cohort studies, type D predicts adverse events in patients with CAD, whereas evidence in patients with HF was inconclusive. In both patients with CAD and HF, we found evidence for a null effect of type D on cardiac and all-cause mortality.
Place, publisher, year, edition, pages
Lippincott Williams & Wilkins, 2023
Keywords
type D personality, cardiovascular disease, meta-analysis, negative affectivity, cardiac events, BF = Bayes factor, CABG = coronary artery bypass grafting, CAD = coronary artery disease, CVD = cardiovascular disease, MACE = major adverse cardiac event, NA = negative affectivity, OR = odds ratio, PCI = percutaneous coronary intervention, SI = social inhibition
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-499310 (URN)10.1097/PSY.0000000000001164 (DOI)000941194800010 ()36640440 (PubMedID)
Funder
EU, European Research Council, 726361
2023-03-292023-03-292023-03-29Bibliographically approved