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Publications (10 of 10) Show all publications
Nordin, K., Persson, J., Stening, E., Herlitz, A., Larsson, E.-M. & Söderlund, H. (2018). Structural whole-brain covariance of the anterior and posterior hippocampus: Associations with age and memory. Hippocampus, 28(2), 151-163
Open this publication in new window or tab >>Structural whole-brain covariance of the anterior and posterior hippocampus: Associations with age and memory
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2018 (English)In: Hippocampus, ISSN 1050-9631, E-ISSN 1098-1063, Vol. 28, no 2, p. 151-163Article in journal (Refereed) Published
Abstract [en]

The hippocampus (HC) interacts with distributed brain regions to support memory and shows significant volume reductions in aging, but little is known about age effects on hippocampal whole-brain structural covariance. It is also unclear whether the anterior and posterior HC show similar or distinct patterns of whole-brain covariance and to what extent these are related to memory functions organized along the hippocampal longitudinal axis. Using the multivariate approach partial least squares, we assessed structural whole-brain covariance of the HC in addition to regional volume, in young, middle-aged and older adults (n = 221), and assessed associations with episodic and spatial memory. Based on findings of sex differences in both memory and brain aging, we further considered sex as a potential modulating factor of age effects. There were two main covariance patterns: one capturing common anterior and posterior covariance, and one differentiating the two regions by capturing anterior-specific covariance only. These patterns were differentially related to associative memory while unrelated to measures of single-item memory and spatial memory. Although patterns were qualitatively comparable across age groups, participants' expression of both patterns decreased with age, independently of sex. The results suggest that the organization of hippocampal structural whole-brain covariance remains stable across age, but that the integrity of these networks decreases as the brain undergoes age-related alterations.

Place, publisher, year, edition, pages
John Wiley & Sons, 2018
Keywords
aging, episodic memory, longitudinal axis, sex, spatial memory
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-335505 (URN)10.1002/hipo.22817 (DOI)000422974700008 ()29171897 (PubMedID)
Funder
Swedish Research Council, 2009-2035Swedish Research Council, 2011-1943
Available from: 2017-12-06 Created: 2017-12-06 Last updated: 2019-06-28Bibliographically approved
Stening, E., Persson, J., Eriksson, E., Wahlund, L.-O., Zetterberg, H. & Söderlund, H. (2017). Specific patterns of whole-brain structural covariance of the anterior and posterior hippocampus in young APOE ε4 carriers. Behavioural Brain Research, 326, 256-264
Open this publication in new window or tab >>Specific patterns of whole-brain structural covariance of the anterior and posterior hippocampus in young APOE ε4 carriers
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2017 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 326, p. 256-264Article in journal (Refereed) Published
Abstract [en]

Apolipoprotein E (APOE) ε4 has been associated with smaller hippocampal volumes in healthy aging, while findings in young adults are inconclusive. Previous studies have mostly used univariate methods, and without considering potential anterior/posterior differences. Here, we used a multivariate method, partial least squares, and assessed whole-brain structural covariance of the anterior (aHC) and posterior (pHC) hippocampus in young adults (n = 97) as a function of APOE ε4 status and sex. Two significant patterns emerged: 1) specific structural covariance of the aHC with frontal regions, temporal and occipital areas in APOE ε4 women, whereas the volume of both the aHC and pHC in all other groups co-varied with frontal, parietal and cerebellar areas; and 2) opposite structural covariance of the pHC in ε4 carriers compared to the aHC in non-carriers, with the pHC of ε4 carriers covarying with parietal and frontal areas, and the aHC of ε4 non-carriers covarying with motor areas and the middle frontal gyrus. APOE ε4 has in young adults been associated with better episodic and spatial memory, functions involving the aHC and pHC, respectively. We found no associations between structural covariance and performance, suggesting that other factors underlie the performance differences seen between carriers and non-carriers. Our findings indicate that APOE ε4 carriers and non-carriers differ in hippocampal organization and that there are differences as a function of sex and hippocampal segment. They stress the need to consider the hippocampus as a heterogeneous structure, and highlight the benefits of multivariate methods in assessing group differences in the brain.

Keywords
APOE ε4, hippocampus, structural covariance, young adults, partial least squares, memory
National Category
Psychology
Identifiers
urn:nbn:se:uu:diva-317322 (URN)10.1016/j.bbr.2017.03.013 (DOI)000401678300028 ()28284953 (PubMedID)
Funder
Swedish Research Council, 2009-2035
Available from: 2017-03-13 Created: 2017-03-13 Last updated: 2017-07-06Bibliographically approved
Stening, E., Persson, J., Eriksson, E., Wahlund, L.-O., Zetterberg, H. & Söderlund, H. (2016). Apolipoprotein E ϵ4 is positively related to spatial performance but unrelated to hippocampal volume in healthy young adults. Behavioural Brain Research, 299, 11-18
Open this publication in new window or tab >>Apolipoprotein E ϵ4 is positively related to spatial performance but unrelated to hippocampal volume in healthy young adults
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2016 (English)In: Behavioural Brain Research, ISSN 0166-4328, E-ISSN 1872-7549, Vol. 299, p. 11-18Article in journal (Refereed) Published
Abstract [en]

The apolipoprotein E (APOE) ϵ4 allele is known to be a major genetic risk factor for Alzheimer's disease (AD). It has been linked to especially episodic memory decline and hippocampal atrophy in both healthy and demented elderly populations. In young adults, ϵ4 carriers have shown better performance in episodic memory compared to non-carriers. Spatial memory, however, has not been thoroughly assessed in relation to APOE in spite of its dependence on the hippocampus. In this study, we assessed the effect of APOE genotype on a variety of spatial and episodic memory tasks as well as hippocampal volume assessed through manual tracing in a sample of young adults (N=123). We also assessed whether potential effects were modulated by sex. The presence of one or more ϵ4 alleles had positive effects on spatial function and memory and object location memory, but no effect on word recognition. Men were superior to women in spatial function and memory but there were no sex differences in the other tasks. In spite of APOE ϵ4 carriers having superior performance in several memory tasks, no difference was found as a function of APOE genotype in hippocampal volume. To our knowledge, this study is the first to show that APOE ϵ4 has a positive effect on spatial ability in young adults.

Keywords
APOE epsilon 4; Spatial memory; Episodic memory; Hippocampus; Manual tracing; Young adults
National Category
Psychology
Identifiers
urn:nbn:se:uu:diva-269688 (URN)10.1016/j.bbr.2015.11.006 (DOI)000368565000003 ()26581118 (PubMedID)
External cooperation:
Funder
Swedish Research Council, 2009-2035
Available from: 2015-12-17 Created: 2015-12-17 Last updated: 2017-12-01
Stening, E. (2015). Resting State Functional Connectivity of the Precuneus and Hippocampus is Differentially Related to Mental Rotation and Episodic Memory Performance in Men and Women. In: : . Paper presented at Cognitive Neuroscience Society 22nd Annual Meeting. March 2015..
Open this publication in new window or tab >>Resting State Functional Connectivity of the Precuneus and Hippocampus is Differentially Related to Mental Rotation and Episodic Memory Performance in Men and Women
2015 (English)Conference paper, Oral presentation only (Other academic)
National Category
Psychology
Identifiers
urn:nbn:se:uu:diva-284565 (URN)
Conference
Cognitive Neuroscience Society 22nd Annual Meeting. March 2015.
Available from: 2016-04-18 Created: 2016-04-18 Last updated: 2016-04-18
Stening, E., Persson, J., Nordin, K., Wikström, J. & Söderlund, H. (2014). Parahippocampal involvement in source encoding: does sex make a difference?. In: : . Paper presented at Poster presented at the Cognitive Neuroscience Society Annual Meeting, Boston, USA..
Open this publication in new window or tab >>Parahippocampal involvement in source encoding: does sex make a difference?
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2014 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Psychology
Identifiers
urn:nbn:se:uu:diva-247568 (URN)
Conference
Poster presented at the Cognitive Neuroscience Society Annual Meeting, Boston, USA.
Available from: 2015-03-20 Created: 2015-03-20 Last updated: 2015-03-23
Nordin, K., Persson, J., Stening, E., Herlitz, A., Morell, A., Wahlund, L.-O., . . . Söderlund, H. (2014). Same strategy–different structure: hippocampal and caudate volume are differently associated with navigation strategy in men and women. In: : . Paper presented at Cognitive Neuroscience Society Annual Meeting, Boston, USA.
Open this publication in new window or tab >>Same strategy–different structure: hippocampal and caudate volume are differently associated with navigation strategy in men and women
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2014 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Psychology
Identifiers
urn:nbn:se:uu:diva-238038 (URN)
Conference
Cognitive Neuroscience Society Annual Meeting, Boston, USA
Note

Poster presented at the Cognitive Neuroscience Society Annual Meeting, Boston, USA

Available from: 2014-12-09 Created: 2014-12-09 Last updated: 2015-03-23
Persson, J., Spreng, N., Turner, G., Herlitz, A., Morell, A., Stening, E., . . . Söderlund, H. (2014). Sex differences in volume and structural covariance of the anterior and posterior hippocampus. In: : . Paper presented at Cognitive Neuroscience Society Annual Meeting, Boston, USA.
Open this publication in new window or tab >>Sex differences in volume and structural covariance of the anterior and posterior hippocampus
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2014 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Psychology
Identifiers
urn:nbn:se:uu:diva-238039 (URN)
Conference
Cognitive Neuroscience Society Annual Meeting, Boston, USA
Note

Poster presented at the Cognitive Neuroscience Society Annual Meeting, Boston, USA

Available from: 2014-12-09 Created: 2014-12-09 Last updated: 2015-03-23
Persson, J., Spreng, R. N., Turner, G., Herlitz, A., Morell, A., Stening, E., . . . Söderlund, H. (2014). Sex differences in volume and structural covariance of the anterior and posterior hippocampus. NeuroImage (99), 215-25
Open this publication in new window or tab >>Sex differences in volume and structural covariance of the anterior and posterior hippocampus
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2014 (English)In: NeuroImage, ISSN 1053-8119, E-ISSN 1095-9572, no 99, p. 215-25Article in journal (Refereed) Published
Abstract [en]

Sex differences in episodic and spatial memory are frequently observed, suggesting that there may be sex-related structural differences in the hippocampus (HC). Earlier findings are inconsistent, possibly due to a known variability along the hippocampal longitudinal axis. Here, we assessed potential sex differences in hippocampal volume and structural covariance with the rest of the brain in young men and women (N=76), considering the anterior (aHC) and posterior (pHC) hippocampus separately. Women exhibited a larger pHC than men adjusted for brain size. Using partial least squares, we identified two significant patterns of structural covariance of the aHC and pHC. The first included brain areas that covaried positively and negatively in volume with both the aHC and pHC in men, but showed greater covariance with the aHC than pHC in women. The second pattern revealed distinct structural covariance of the aHC and pHC that showed a clear difference between men and women: in men the pHC showed reliable structural covariance with the medial and lateral parietal lobes and the prefrontal cortex, whereas in women the aHC showed reliable structural covariance with the anterior temporal lobe bilaterally. This pattern converges with resting state functional connectivity of the aHC and pHC and suggests that these hippocampal sections interact with different brain regions, consistent with a division of labor with regards to episodic and spatial memory. Our findings lend support to a division of the HC into an anterior and posterior part and identify sex as a potential moderating factor when investigating hippocampal structure and connectivity.

National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
urn:nbn:se:uu:diva-225425 (URN)10.1016/j.neuroimage.2014.05.038 (DOI)000339860000023 ()24857714 (PubMedID)
Available from: 2014-06-03 Created: 2014-06-03 Last updated: 2017-12-05Bibliographically approved
Persson, J., Stening, E., Wikström, J. & Söderlund, H. (2013). A Network For Navigation: Cross-Hemispheric Hippocampal Connectivity Predicts Water Maze Performance. Paper presented at 20th Annual Meeting of the Cognitive-Neuroscience-Society, APR 13-16, 2013, San Francisco, CA, USA. Journal of cognitive neuroscience (Supplement), 199-199
Open this publication in new window or tab >>A Network For Navigation: Cross-Hemispheric Hippocampal Connectivity Predicts Water Maze Performance
2013 (English)In: Journal of cognitive neuroscience, ISSN 0898-929X, E-ISSN 1530-8898, no Supplement, p. 199-199Article in journal, Meeting abstract (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-200276 (URN)000317030501124 ()
Conference
20th Annual Meeting of the Cognitive-Neuroscience-Society, APR 13-16, 2013, San Francisco, CA, USA
Available from: 2013-05-24 Created: 2013-05-24 Last updated: 2017-12-06Bibliographically approved
Stening, E., Persson, J., Wikström, J. & Söderlund, H. (2013). The Precuneus Makes The Difference: Precuneal Activity During Recollection Of Concrete Compared To Abstract Nouns Is Linked To Retrieval Success. Paper presented at 20th Annual Meeting of the Cognitive-Neuroscience-Society, APR 13-16, 2013, San Francisco, CA, USA. Journal of cognitive neuroscience (Supplement), 227-227
Open this publication in new window or tab >>The Precuneus Makes The Difference: Precuneal Activity During Recollection Of Concrete Compared To Abstract Nouns Is Linked To Retrieval Success
2013 (English)In: Journal of cognitive neuroscience, ISSN 0898-929X, E-ISSN 1530-8898, no Supplement, p. 227-227Article in journal, Meeting abstract (Other academic) Published
National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-200277 (URN)000317030501255 ()
Conference
20th Annual Meeting of the Cognitive-Neuroscience-Society, APR 13-16, 2013, San Francisco, CA, USA
Available from: 2013-05-24 Created: 2013-05-24 Last updated: 2017-12-06Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0003-0354-5228

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