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Hultström, M., Becriovic-Agic, M. & Jönsson, S. (2018). Comparison of acute kidney injury of different aetiology reveals in-common mechanisms of tissue damage. Physiological Genomics, 50(3), 127-141
Open this publication in new window or tab >>Comparison of acute kidney injury of different aetiology reveals in-common mechanisms of tissue damage
2018 (English)In: Physiological Genomics, ISSN 1094-8341, E-ISSN 1531-2267, Vol. 50, no 3, p. 127-141Article, review/survey (Refereed) Published
Abstract [en]

Acute kidney injury (AKI) is a syndrome of reduced glomerular filtration rate (GFR) and urine production caused by a number of different diseases. It is associated with renal tissue damage. This tissue damage can cause tubular atrophy and interstitial fibrosis that leads to nephron loss and progression of chronic kidney disease (CKD). This review describes the in-common mechanisms behind tissue damage in AKI caused by different underlying diseases. Comparing six high-quality microarray studies of renal gene expression after AKI in disease models (gram-negative sepsis, gram-positive sepsis, ischemia-reperfusion, malignant hypertension, rhabdomyolysis and cisplatin toxicity) identified 5254 differentially expressed genes in at least one of the AKI models. 66% of genes were only found in one model showing that there are unique features to AKI depending on the underlying disease. There were in-common features in the form of four genes that were differentially expressed in all six models, 49 in at least five, and 215 were in-common between at least four models. Gene ontology enrichment analysis could be broadly categorized into the injurious processes hypoxia, oxidative stress, and inflammation, as well as the cellular outcomes of cell death and tissue remodeling in the form of epithelial to mesenchymal transition (EMT). Pathway analysis showed that MYC is a central connection in the network of activated genes in-common to AKI, which suggests that it may be a central regulator of renal gene expression in tissue injury during AKI. The outlining of this molecular network may be useful for understanding progression from AKI to CKD.

Keywords
acute kidney injury, biomarker, gene expression, molecular, tissue injury
National Category
Physiology
Research subject
Physiology
Identifiers
urn:nbn:se:uu:diva-340389 (URN)10.1152/physiolgenomics.00037.2017 (DOI)000428814500001 ()29341864 (PubMedID)
Funder
Swedish Society for Medical Research (SSMF)
Available from: 2018-01-29 Created: 2018-01-29 Last updated: 2018-08-14Bibliographically approved
Colldén, J., Hultström, M. & Birgisdottir, B. (2017). Case of subdural hematoma after labor epidural: implications for follow-up of post dural puncture head ache. Acta Anaesthesiologica Scandinavica, 61(8), 985-985
Open this publication in new window or tab >>Case of subdural hematoma after labor epidural: implications for follow-up of post dural puncture head ache
2017 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 61, no 8, p. 985-985Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-342124 (URN)000407231100048 ()
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-02-22Bibliographically approved
Wang, R., Zhang, W., Dong, Z., Qi, Y., Hultström, M., Zhou, X. & Lai, E. Y. (2017). c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression. Acta Physiologica, 219(2), 494-509
Open this publication in new window or tab >>c-Jun N-terminal Kinase mediates prostaglandin-induced sympathoexcitation in rats with chronic heart failure by reducing GAD1 and GABRA1 expression
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2017 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 219, no 2, p. 494-509Article in journal (Refereed) Published
Abstract [en]

AIM: Prostaglandin E2 mediates sympathoexcitation in chronic heart failure (CHF) through EP3 receptors (PTGER3) in the paraventricular nucleus (PVN). The aim of this study was to investigate the role of c-Jun N-terminal kinase (JNK) in expressional regulation of gamma-aminobutyric acid signalling in PVN in CHF rats.

METHODS: Chronic heart failure was induced by left coronary ligation in Wistar rats. Renal sympathetic nerve discharge (RSND) and mean arterial pressure (MAP) responses to the PVN infusion were determined in anaesthetized rats. Osmotic minipumps were used for chronic PVN infusion. PTGER3 expression was examined with immunofluorescence staining, quantitative real-time PCR and Western blot.

RESULTS: Chronic heart failure rats had increased JNK activation and decreased glutamate decarboxylase 1 (GAD1) and GABAA receptor alpha 1 subunit (GABRA1) expression in the PVN. PVN infusion of the PTGER3 agonist SC-46275 caused sympathoexcitation in sham-operated control (Sham) rats and increased it further in CHF. The PTGER3 antagonist L798106 reduced sympathoexcitation and cardiac dysfunction in CHF. PVN infusion of EP1 receptor antagonist SC-19220, EP2 receptor antagonist AH6809 or EP4 receptor antagonist L-161982 had no effect on sympathoexcitation. The JNK inhibitor SP600125 normalized sympathoexcitation and GAD1 and GABRA1 expression in PVN in CHF rats. Both the p44/42 and p38 mitogen-activated protein kinase inhibitors PD98059 and SB203580 could not prevent the downregulation of GAD1 and GABRA1 expression in PVN in CHF. PTGER3 agonist activated JNK but downregulated GAD1 and GABRA1 expression in NG108 neuronal cells.

CONCLUSION: Prostaglandin signalling through upregulated PTGER3 activates JNK which reduces GAD1 and GABRA1 expression in the PVN, and contributes to sympathoexcitation in CHF.

Keywords
EP3 receptor, c-Jun N-terminal kinase, chronic heart failure, paraventricular nucleus, sympathetic nerve discharge
National Category
Physiology
Identifiers
urn:nbn:se:uu:diva-318019 (URN)10.1111/apha.12758 (DOI)000393912000014 ()27439062 (PubMedID)
Funder
Swedish Heart Lung Foundation
Available from: 2017-03-23 Created: 2017-03-23 Last updated: 2018-01-13Bibliographically approved
Weigl, W., Adamski, J., Gorynski, P., Kanski, A. & Hultström, M. (2017). Comparison of ICU outcomes in Poland to other European countries: reasons for high mortality rates. Acta Anaesthesiologica Scandinavica, 61(8), 1022-1023
Open this publication in new window or tab >>Comparison of ICU outcomes in Poland to other European countries: reasons for high mortality rates
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2017 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 61, no 8, p. 1022-1023Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-342128 (URN)000407231100106 ()
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-02-22Bibliographically approved
Becriovic Agic, M., Jönsson, S. & Hultström, M. (2017). Genetic association of oxidative stress and fluid accumulation makes Balb/CJ mice more sensitive to decompensated heart failure. Acta Anaesthesiologica Scandinavica, 61(8), 963-964
Open this publication in new window or tab >>Genetic association of oxidative stress and fluid accumulation makes Balb/CJ mice more sensitive to decompensated heart failure
2017 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 61, no 8, p. 963-964Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-342121 (URN)000407231100016 ()
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-02-22Bibliographically approved
Hultström, M. (2017). In-common molecular pathway for six different etiologies of acute kidney injury. Acta Anaesthesiologica Scandinavica, 61(8), 1041-1041
Open this publication in new window or tab >>In-common molecular pathway for six different etiologies of acute kidney injury
2017 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 61, no 8, p. 1041-1041Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-342132 (URN)000407231100133 ()
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-02-22Bibliographically approved
Peng, D., Hultström, M., Cupples, C., Cupples, W. & Mitrou, N. (2017). Macrophage infiltration in the kidney after prolonged surgery with anesthesia. Acta Anaesthesiologica Scandinavica, 61(8), 1010-1011
Open this publication in new window or tab >>Macrophage infiltration in the kidney after prolonged surgery with anesthesia
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2017 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 61, no 8, p. 1010-1011Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-342126 (URN)000407231100087 ()
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-02-22
Knapik, P., Krzych, Ł. J., Weigl, W., Adamski, J. & Hultström, M. (2017). Mortality rate in Polish intensive care units is lower than predicted according to the APACHE II scoring system. [Letter to the editor]. Intensive Care Medicine, 43, 1745-1746
Open this publication in new window or tab >>Mortality rate in Polish intensive care units is lower than predicted according to the APACHE II scoring system.
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2017 (English)In: Intensive Care Medicine, ISSN 0342-4642, E-ISSN 1432-1238, Vol. 43, p. 1745-1746Article in journal, Letter (Other academic) Published
Keywords
intensive care mortality score risk
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-331558 (URN)10.1007/s00134-017-4883-0 (DOI)000412567400036 ()28733717 (PubMedID)
Available from: 2017-10-14 Created: 2017-10-14 Last updated: 2018-03-22Bibliographically approved
Jönsson, S., Melville, J. & Hultström, M. (2017). Norepinephrine effects are not affected by Losartan in rats after resuscitated haemorrhage. Acta Anaesthesiologica Scandinavica, 61(8), 963-963
Open this publication in new window or tab >>Norepinephrine effects are not affected by Losartan in rats after resuscitated haemorrhage
2017 (English)In: Acta Anaesthesiologica Scandinavica, ISSN 0001-5172, E-ISSN 1399-6576, Vol. 61, no 8, p. 963-963Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
WILEY, 2017
National Category
Anesthesiology and Intensive Care
Identifiers
urn:nbn:se:uu:diva-342122 (URN)000407231100015 ()
Available from: 2018-02-22 Created: 2018-02-22 Last updated: 2018-02-22Bibliographically approved
Melville, J. M., Palm, F. & Hultström, M. (2016). Renal oxygenation during haemorrhage is not aggravated by angiotensin II AT1-receptor blockade. Acta Physiologica, 216(2), 153-155
Open this publication in new window or tab >>Renal oxygenation during haemorrhage is not aggravated by angiotensin II AT1-receptor blockade
2016 (English)In: Acta Physiologica, ISSN 1748-1708, E-ISSN 1748-1716, Vol. 216, no 2, p. 153-155Article in journal, Editorial material (Refereed) Published
National Category
Physiology
Identifiers
urn:nbn:se:uu:diva-265417 (URN)10.1111/apha.12580 (DOI)000367950300002 ()26300043 (PubMedID)
Available from: 2015-10-28 Created: 2015-10-28 Last updated: 2018-01-10Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-4675-1099

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