uu.seUppsala University Publications
Change search
Link to record
Permanent link

Direct link
BETA
Olofsdotter, SusanneORCID iD iconorcid.org/0000-0002-8114-8386
Publications (9 of 9) Show all publications
Torres Soler, C., Olofsdotter, S., Vadlin, S., Ramklint, M., Nilsson, K. W. & Sonnby, K. (2018). Diagnostic accuracy of the Montgomery-Åsberg Depression Rating Scale parent report among adolescent psychiatric outpatients. Nordic Journal of Psychiatry, 72(3), 184-190
Open this publication in new window or tab >>Diagnostic accuracy of the Montgomery-Åsberg Depression Rating Scale parent report among adolescent psychiatric outpatients
Show others...
2018 (English)In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 72, no 3, p. 184-190Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: The diagnostic accuracy of the parent report of the Montgomery-Åsberg Depression Rating Scale (MADRS-P) for the screening of major depressive disorder (MDD) in adolescents has not been evaluated.

AIM: The aim was to explore the psychometric properties and diagnostic accuracy of the MADRS-P in general child and adolescent psychiatric outpatient services in Sweden.

METHOD: The study was a validation and a diagnostic accuracy study. Consecutive adolescent psychiatric patients (n = 101, 45 males, mean age 15 years) were assessed with a diagnostic interview, the Kiddie Schedule of Affective Disorders and Schizophrenia for School-Age Children - Present and Lifetime version (K-SADS-PL), as a reference test. Thereafter, their parents reported on the MADRS-P. Both categorical MDD diagnoses and dimensional MDD symptom severity scores were obtained from the K-SADS-PL.

RESULTS: The internal consistency of the MADRS-P, measured with Cronbach's alpha, was 0.846. The concurrent validity, assessed by Spearman's rho as a correlation between the K-SADS MDD symptom severity score and the MADRS-P score, was 0.580. The area under the curve in a receiver operating characteristic analysis for all participants was 0.786 (95% confidence interval 0.694-0.877, p < .001). At a cut-off of 10, sensitivity was 0.86, specificity 0.54, positive predictive value 0.59 and negative predictive value 0.84.

CONCLUSIONS: The parent-rated MADRS-P showed similar psychometric properties as previously shown for the self-rated MADRS-S in adults. Although the MADRS-P has acceptable diagnostic accuracy for screening for MDD in adolescents in a general psychiatric setting, it cannot be used alone for diagnosing MDD.

Place, publisher, year, edition, pages
Taylor & Francis Group, 2018
Keywords
Depression, adolescents, parents, questionnaire, validation study
National Category
Clinical Medicine
Research subject
Psychiatry
Identifiers
urn:nbn:se:uu:diva-342265 (URN)10.1080/08039488.2017.1414873 (DOI)000424948600005 ()29258381 (PubMedID)
Available from: 2018-02-19 Created: 2018-02-19 Last updated: 2018-04-10Bibliographically approved
Olofsdotter, S., Åslund, C., Furmark, T., Comasco, E. & Nilson, K. W. (2018). Differential susceptibility effects of oxytocin gene (OXT) polymorphisms and perceived parenting on social anxiety among adolescents. Development and psychopathology (Print), 30(2), 449-459
Open this publication in new window or tab >>Differential susceptibility effects of oxytocin gene (OXT) polymorphisms and perceived parenting on social anxiety among adolescents
Show others...
2018 (English)In: Development and psychopathology (Print), ISSN 0954-5794, E-ISSN 1469-2198, Vol. 30, no 2, p. 449-459Article in journal (Refereed) Published
Abstract [en]

Social anxiety is one of the most commonly reported mental health problems among adolescents, and it has been suggested that parenting style influences an adolescent's level of anxiety. A context-dependent effect of oxytocin on human social behavior has been proposed; however, research on the oxytocin gene (OXT) has mostly been reported without considering contextual factors. This study investigated the interactions between parenting style and polymorphic variations in the OXT gene in association with social anxiety symptoms in a community sample of adolescents (n = 1,359). Two single nucleotide polymorphisms linked to OXT, rs4813625 and rs2770378, were genotyped. Social anxiety and perceived parenting style were assessed by behavioral questionnaires. In interaction models adjusted for sex, significant interaction effects with parenting style were observed for both variants in relation to social anxiety. The nature of the interactions was in line with the differential susceptibility framework for rs4813625, whereas for rs2770378 the results indicated a diathesis–stress type of interaction. The findings may be interpreted from the perspective of the social salience hypothesis of oxytocin, with rs4813625 affecting social anxiety levels along a perceived unsafe–safe social context dimension.

National Category
Neurosciences Psychology
Identifiers
urn:nbn:se:uu:diva-323574 (URN)10.1017/S0954579417000967 (DOI)000430924500006 ()28606214 (PubMedID)
Funder
Fredrik och Ingrid Thurings StiftelseThe Swedish Brain Foundation, F02015-0315Forte, Swedish Research Council for Health, Working Life and Welfare, FORTE 2015-00897Åke Wiberg Foundation, MI5-0239Swedish Research Council, VR 2015-00495EU, FP7, Seventh Framework Programme, INCA 600398Stiftelsen Söderström - Königska sjukhemmet, SLS-559921
Available from: 2017-06-08 Created: 2017-06-08 Last updated: 2019-04-04Bibliographically approved
Olofsdotter, S., Furmark, T., Åslund, C. & Nilsson, K. W. (2018). The mediating role of parenting behaviors in the relationship between early and late adolescent levels of anxiety: Specificity and informant effects. Journal of Adolescence, 69, 118-129
Open this publication in new window or tab >>The mediating role of parenting behaviors in the relationship between early and late adolescent levels of anxiety: Specificity and informant effects
2018 (English)In: Journal of Adolescence, ISSN 0140-1971, E-ISSN 1095-9254, Vol. 69, p. 118-129Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: The role of parenting behavior is often highlighted in the development of anxiety in youth. However, previous reports are limited in terms of the specificity of relationships between different types of anxiety and parenting behaviors, informant effects on these relationships, and direction of effects.

METHODS: This study investigates these questions using longitudinal data from 1350 Swedish adolescents and their parents. Adolescents' self-reports of six dimensions of anxiety and adolescents' and parents' reports of six dimensions of parenting behaviors were used in the analyses. Parallel multiple mediation models were employed to analyze specificity and informant effects within a reciprocal effects model.

RESULTS: Overall, and irrespective of informant, this study found little support for a mediating role of parenting behaviors in the relationship between early and late adolescent levels of anxiety. Evidence for specificity within the parenting-anxiety relationship was scarce with specific mediating effects observed only for panic/agoraphobia and total anxiety through the parenting dimension of rejection.

CONCLUSIONS: The findings of this study concern the un-conditional mediating role of parenting. Parenting behaviors may be more influential among some adolescents, depending on individual differences in other factors related to the development and course of adolescent anxiety. Thus, further research on moderating factors of the influence of parenting on adolescent anxiety is warranted.

Keywords
Adolescence, Anxiety, Mediator, Parenting
National Category
Neurosciences
Research subject
Child and Youth Psychiatry; Child and Youth Psychiatry
Identifiers
urn:nbn:se:uu:diva-374321 (URN)10.1016/j.adolescence.2018.09.011 (DOI)000458345900014 ()30292944 (PubMedID)
Funder
The Swedish Brain Foundation, F02015-0315Fredrik och Ingrid Thurings StiftelseForte, Swedish Research Council for Health, Working Life and Welfare, 2015-00897Åke Wiberg Foundation, MI5-0239
Available from: 2019-01-20 Created: 2019-01-20 Last updated: 2019-03-12Bibliographically approved
Olofsdotter, S. (2017). Anxiety among Adolescents: Measurement, Clinical Characteristics, and Influences of Parenting and Genetics. (Doctoral dissertation). Uppsala: Acta Universitatis Upsaliensis
Open this publication in new window or tab >>Anxiety among Adolescents: Measurement, Clinical Characteristics, and Influences of Parenting and Genetics
2017 (English)Doctoral thesis, comprehensive summary (Other academic)
Abstract [en]

Anxiety is the most commonly reported mental health problem among adolescents. Still, many adolescents in need of treatment are not detected and the clinical characteristics and etiological pathways of adolescent anxiety are under-researched topics. This thesis examined the clinical utility of the Swedish versions of the Spence Children’s Anxiety Scale (SCAS) and the clinical characteristics of multiple anxiety disorders among psychiatrically referred adolescents, and the influence of parenting and oxytocin gene (OXT) variants on anxiety among adolescents in the general population.  Studies employed cross-sectional and longitudinal designs and were based on questionnaire, interview, and genotype data.

Support for the reliability and validity of both SCAS and SCAS-P was obtained. The overall ability to predict anxiety among referred adolescents ranged from fair to excellent for both scales. 

Among adolescents psychiatrically referred for any reason, the prevalence of any anxiety disorder was 46%. Homotypic comorbidity was observed in 43%, and heterotypic comorbidity in 91%.

Early adolescent anxiety influenced homotypic anxiety in late adolescence independent of parental rejection and control. The mediating role of parenting was small with indirect effect sizes no larger than one-tenth the size of direct effects, irrespective of the informant on parenting behavior.

Significant interaction effects with positive and negative parenting were observed for OXT variants rs4813625 and rs2770378 in relation to social anxiety. The nature of the interactions was in line with the differential susceptibility framework for rs4813625, whereas for rs2770378, results indicated a diathesis–stress type of interaction.

The findings suggest that psychiatrically referred adolescents with anxiety disorders are best characterized as a highly complex patient group and call attention to the necessity of structured assessment. For this purpose, this thesis provides evidence for the clinical utility of the SCAS; routine utilization of this questionnaire can improve detection of adolescents in need of anxiety treatment. Findings of this theses further suggest that the influence of positive and negative parenting behaviors on anxiety may be of greater importance among some adolescents than others, depending on individual differences in sensitivity to parenting. The etiology of anxiety among adolescents may therefore involve differential susceptibility effects of the interplay between genes and parenting behaviors.

Place, publisher, year, edition, pages
Uppsala: Acta Universitatis Upsaliensis, 2017. p. 108
Series
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1356
Keywords
Adolescent, anxiety, assessment, prevalence, comorbidity, parenting, oxytocin, gene–environment interaction, differential susceptibility
National Category
Neurosciences
Research subject
Child and Youth Psychiatry
Identifiers
urn:nbn:se:uu:diva-323578 (URN)978-91-513-0033-7 (ISBN)
Public defence
2017-10-20, Vårdskolans aula, Ingång 21, Västmanlands sjukhus, Västerås, 13:15 (Swedish)
Opponent
Supervisors
Available from: 2017-09-29 Created: 2017-08-14 Last updated: 2018-01-13
Olofsdotter, S., Åslund, C., Furmark, T., Comasco, E. & Nillson, K. W. (2017). Interaction between oxytocin gene variants and perceived parenting in relation to social anxiety in adolescents: Evidence for differential susceptibility effects. European psychiatry, 41, S72-S72
Open this publication in new window or tab >>Interaction between oxytocin gene variants and perceived parenting in relation to social anxiety in adolescents: Evidence for differential susceptibility effects
Show others...
2017 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 41, p. S72-S72Article in journal, Meeting abstract (Other academic) Published
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-335827 (URN)10.1016/j.eurpsy.2017.01.231 (DOI)000404952200218 ()
Available from: 2018-01-12 Created: 2018-01-12 Last updated: 2018-01-12Bibliographically approved
Olofsdotter, S., Vadlin, S., Sonnby, K., Furmark, T. & Nilsson, K. W. (2016). Anxiety disorders among adolescents referred to general psychiatry for multiple causes: clinical presentation, prevalence, and comorbidity. Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, 4(2), 55-64
Open this publication in new window or tab >>Anxiety disorders among adolescents referred to general psychiatry for multiple causes: clinical presentation, prevalence, and comorbidity
Show others...
2016 (English)In: Scandinavian Journal of Child and Adolescent Psychiatry and Psychology, E-ISSN 2245-8875, Vol. 4, no 2, p. 55-64Article in journal (Refereed) Published
Abstract [en]

Reports of anxiety disorder characteristics among youth in clinical settings typically include descriptions of patients who have been specifically referred for anxiety treatment. At odds with a large body of evidence which demonstrates these disorders to be most common among young people, prevalence studies in samples referred to general psychiatry for multiple causes are scarce and report highly discrepant estimates.

For this study and regardless of their presenting symptoms, 125 adolescents (57.6% girls) between the ages of 12 and 18 years who were consecutively referred to two child and adolescent general psychiatry clinics in Sweden were assessed for anxiety disorders and comorbidity using the Schedule for Affective Disorders and Schizophrenia for School-Age Children. Self-ratings of anxiety symptoms and difficulties with family, school, friends, sleep, and body aches were also obtained.

At least one anxiety disorder was found in 46% of participants. Among anxious adolescents, homotypic comorbidity (concurrent anxiety) was observed in 43%, and heterotypic comorbidity (concurrent non-anxiety psychiatric disorders) was observed in 91%. No comorbidity was observed in 5%. Trauma, ache, and difficulties making friends were more common among anxious adolescents as compared with psychiatrically referred adolescents without anxiety.

The finding that only 21% of adolescents diagnosed with anxiety disorders were referred for anxiety further supports the routine use of standardized and structured instruments—irrespective of referral cause—to improve both precision and detection rates in the clinical setting. Comprehensive assessments are of utmost importance to fully address the complexity of the symptoms in this patient group.

National Category
Neurosciences
Research subject
Child and Youth Psychiatry
Identifiers
urn:nbn:se:uu:diva-323571 (URN)10.21307/sjcapp-2016-010 (DOI)
Available from: 2017-06-08 Created: 2017-06-08 Last updated: 2018-08-16Bibliographically approved
Olofsdotter, S., Sonnby, K., Vadlin, S., Furmark, T. & Nilsson, K. W. (2016). Assessing Adolescent Anxiety in General Psychiatric Care: Diagnostic Accuracy of the Swedish Self-Report and Parent Versions of the Spence Children's Anxiety Scale. Assessment (Odessa, Fla.), 23(6), 744-757
Open this publication in new window or tab >>Assessing Adolescent Anxiety in General Psychiatric Care: Diagnostic Accuracy of the Swedish Self-Report and Parent Versions of the Spence Children's Anxiety Scale
Show others...
2016 (English)In: Assessment (Odessa, Fla.), ISSN 1073-1911, E-ISSN 1552-3489, Vol. 23, no 6, p. 744-757Article in journal (Refereed) Published
Abstract [en]

This study examined the psychometric properties and diagnostic accuracy of the Swedish translations of the Spence Children's Anxiety Scale, self- and parent report versions, in a sample of 104 adolescents presenting at two general psychiatric outpatient units. Results showed high informant agreement and good internal reliability and concurrent and discriminant validity for both versions and demonstrated that this scale can distinguish between adolescents with and without an anxiety disorder in a non-anxiety-specific clinical setting. The relative clinical utility of different cutoff scores was compared by looking at the extent to which dichotomized questionnaire results altered the pretest probability of the presence of a diagnosis as defined by the Schedule for Affective Disorders and Schizophrenia for School-Age Children. Optimized for screening and diagnostic purposes in Sweden, cutoff scores obtained in the current study outperformed a previously identified cutoff score derived from an Australian community sample. The Spence Children's Anxiety Scale is a useful clinical instrument for the assessment of anxiety in adolescents.

Keywords
anxiety disorders, adolescents, Spence Children's Anxiety Scale, test validity, diagnostic accuracy
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-252419 (URN)10.1177/1073191115583858 (DOI)000388676500008 ()25934162 (PubMedID)
Available from: 2015-05-06 Created: 2015-05-06 Last updated: 2018-01-11Bibliographically approved
Sjölander, L., Vadlin, S., Olofsdotter, S. & Sonnby, K. (2016). Validation of the parent version of the World Health Organization Adult ADHD Self-Report Scale for adolescents.. Nordic Journal of Psychiatry, 70(4), 255-261
Open this publication in new window or tab >>Validation of the parent version of the World Health Organization Adult ADHD Self-Report Scale for adolescents.
2016 (English)In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 70, no 4, p. 255-261Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: To investigate the validity of a parent version of the World Health Organization Adult Attention-Deficit/Hyperactivity Disorder (ADHD) Self-Report Scale for adolescents (ASRS-AP) and the 6-question screening version (ASRS-AP-S).

METHODS: Adolescent psychiatric outpatients (N = 112, mean age 15 years, 40% boys) and their parents were interviewed with the Kiddie Schedule of Affective Disorders and Schizophrenia (K-SADS), and the parents reported on the ASRS-AP/ASRS-AP-S.

RESULTS: Internal consistency (Cronbach's alpha) was 0.93 for ASRS-AP and 0.85 for ASRS-AP-S, 0.91 and 0.87 for the inattention subscale, and 0.91 and 0.72 for the hyperactivity subscale, respectively. The concurrent validity (Spearman's correlation coefficient) between the total K-SADS ADHD symptom severity score and the sum of the score on the ASRS-AP/ASRS-AP-S was 0.75 and 0.66, respectively. Diagnostic accuracy measures for the ASRS-AP and ASRS-AP-S were 78% and 80% sensitivity, 75% and 74% specificity, 73% and 71% positive predictive value (PPV), and 81% and 82% negative predictive value (NPV), respectively.

CONCLUSIONS: The ASRS-AP and ASRS-AP-S showed high internal consistency and concurrent validity in relation to total K-SADS ADHD symptom severity score. Both scales showed favourable diagnostic accuracy measures.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-281760 (URN)10.3109/08039488.2015.1085092 (DOI)000373021800003 ()26624978 (PubMedID)
Available from: 2016-03-30 Created: 2016-03-30 Last updated: 2017-11-30Bibliographically approved
Sonnby, K., Skordas, K., Olofsdotter, S., Vadlin, S., Nilsson, K. W. & Ramklint, M. (2015). Validation of the World Health Organization Adult ADHD Self-Report Scale for adolescents. Nordic Journal of Psychiatry, 69(3), 216-223
Open this publication in new window or tab >>Validation of the World Health Organization Adult ADHD Self-Report Scale for adolescents
Show others...
2015 (English)In: Nordic Journal of Psychiatry, ISSN 0803-9488, E-ISSN 1502-4725, Vol. 69, no 3, p. 216-223Article in journal (Refereed) Published
Abstract [en]

Background: The World Health Organization Adult ADHD Self Report Scale (ASRS) is a widely used diagnostic tool for assessment of attention-deficit hyperactivity disorder (ADHD) symptoms in clinical psychiatry in Sweden. The ASRS consists of 18 questions, the first six of which can be used as a short screening version (ASRS-S). There is a version for adolescents—ASRS-Adolescent (ASRS-A)—and the corresponding screening version (ASRS-A-S), which has not been validated to date.

Aim: The aim was to validate the ASRS-A and the ASRS-A-S for use in adolescent clinical populations.

Methods: Adolescent psychiatric outpatients (n = 134, mean age 15 years, 40% boys) reported on the ASRS-A, and were interviewed with the Kiddie Schedule of Affective Disorders and Schizophrenia (K-SADS), a semi-structured interview, together with a parent.

Results: Internal consistency was 0.79 for the ASRS-A-S and 0.92 for the ASRS-A (Cronbach's alpha). Internal consistency values were 0.79 and 0.87 for the inattention subscale, and 0.68 and 0.89 for the hyperactivity subscale, respectively. Concurrent validity values, measured with Spearman's correlation coefficient, between the total K-SADS ADHD symptom severity score and the sum of ASRS-A-S and ASRS-A total scores were 0.51 and 0.60, respectively. Psychometric properties of the ASRS-A-S and the ASRS-A were: sensitivity 74% and 79%; negative predictive value 81% and 84%; specificity 59% and 60%; and positive predictive value 49% and 51%, respectively. Both versions showed better properties for girls than for boys.

Conclusion: Both the ASRS-A-S and the ASRS-A showed promising psychometric properties for use in adolescent clinical populations.

Keywords
Validation Study, Attention Deficit Disorder with Hyperactivity, Adolescent
National Category
Psychiatry
Research subject
Child and Youth Psychiatry
Identifiers
urn:nbn:se:uu:diva-219112 (URN)10.3109/08039488.2014.968203 (DOI)000351231500009 ()25348323 (PubMedID)
Available from: 2014-02-21 Created: 2014-02-21 Last updated: 2017-12-05Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-8114-8386

Search in DiVA

Show all publications