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Andres, Julien
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Xiong, R., Andres, J., Scheffler, K. & Borbas, E. K. (2015). Synthesis and characterisation of lanthanide-hydroporphyrin dyads. Dalton Transactions, 44(6), 2541-2553
Open this publication in new window or tab >>Synthesis and characterisation of lanthanide-hydroporphyrin dyads
2015 (English)In: Dalton Transactions, ISSN 1477-9226, E-ISSN 1477-9234, Vol. 44, no 6, p. 2541-2553Article in journal (Refereed) Published
Abstract [en]

Fluorescence spectroscopy is in many ways the ideal tool for the interrogation of complex biological systems, as it is non-invasive, sensitive, and offers high spatiotemporal resolution. For biomedical imaging luminescent probes absorbing and emitting in the red-to-near infrared (NIR) region are best suited to maximise tissue penetration and minimise damage to cellular components. NIR-emitting lanthanides (Ln) sensitised with red-absorbing antennae are promising candidates for these applications, assuming the challenges of poor photophysical properties and tedious syntheses of the complexes are overcome. Chlorins are porphyrin-type tetrapyrroles with intense red absorption. Recently chlorins have been shown to sensitise Yb and Nd emission when incorporated into Ln-complexes. Here we expand on our previous work, and explore the effect of chlorin structure, metallation state, chlorin-Ln-complex linker length and mode of attachment on the properties of chlorin-Ln complexes. As chlorin absorption bands are similar to 20 nm fwhm and readily tunable, a deeper understanding of structure-property relationships would enable the use of chlorin-Ln complexes in multicolour imaging using antenna-specific excitation. A detailed description of antenna and complex syntheses and photophysical characterisation is given. A number of challenges were identified, which will have to be addressed in future studies to enable multicolour imaging using the NIR-emitting lanthanides.

National Category
Chemical Sciences
urn:nbn:se:uu:diva-247181 (URN)10.1039/c4dt02448f (DOI)000349009800004 ()25340852 (PubMedID)
Swedish Research Council, 2013-4655
Available from: 2015-03-13 Created: 2015-03-13 Last updated: 2017-12-04Bibliographically approved

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