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Katsarogiannis, Evangelos
Publications (3 of 3) Show all publications
Landtblom, A.-M. -., Katsarogiannis, E., Kristoffersson, A., Berntsson, S. G., Semnic, R. & Boström, I. (2018). Challenges in diagnosing OCB-negative MS - the importance of imaging. Paper presented at 34th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), OCT 10-12, 2018, Berlin, GERMANY. Multiple Sclerosis, 24, 743-743
Open this publication in new window or tab >>Challenges in diagnosing OCB-negative MS - the importance of imaging
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2018 (English)In: Multiple Sclerosis, ISSN 1352-4585, E-ISSN 1477-0970, Vol. 24, p. 743-743Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
Sage Publications, 2018
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-369959 (URN)000446861402011 ()
Conference
34th Congress of the European-Committee-for-Treatment-and-Research-in-Multiple-Sclerosis (ECTRIMS), OCT 10-12, 2018, Berlin, GERMANY
Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2018-12-17Bibliographically approved
Berntsson, S. G., Katsarogiannis, E., Lourenco, F. & Moraes-Fontes, M. F. (2016). Progressive Multifocal Leukoencephalopathy and Systemic Lupus Erythematosus: Focus on Etiology. Case Reports in Neurology, 8(1), 59-65
Open this publication in new window or tab >>Progressive Multifocal Leukoencephalopathy and Systemic Lupus Erythematosus: Focus on Etiology
2016 (English)In: Case Reports in Neurology, ISSN 1662-680X, E-ISSN 1662-680X, Vol. 8, no 1, p. 59-65Article in journal (Refereed) Published
Abstract [en]

Progressive multifocal leukoencephalopathy (PML) caused by reactivation of the JC virus (JCV), a human polyomavirus, occurs in autoimmune disorders, most frequently in systemic lupus erythematosus (SLE). We describe a HIV-negative 34-year-old female with SLE who had been treated with immunosuppressant therapy (IST; steroids and azathioprine) since 2004. In 2011, she developed decreased sensation and weakness of the right hand, followed by vertigo and gait instability. The diagnosis of PML was made on the basis of brain MRI findings (posterior fossa lesions) and JCV isolation from the cerebrospinal fluid (700 copies/ml). IST was immediately discontinued. Cidofovir, mirtazapine, mefloquine and cycles of cytarabine were sequentially added, but there was progressive deterioration with a fatal outcome 1 year after disease onset. This report discusses current therapeutic choices for PML and the importance of early infection screening when SLE patients present with neurological symptoms. In the light of recent reports of PML in SLE patients treated with rituximab or belimumab, we highlight that other IST may just as well be implicated. We conclude that severe lymphopenia was most likely responsible for JCV reactivation in this patient and discuss how effective management of lymphopenia in SLE and PML therapy remains an unmet need.

Keywords
Progressive multifocal leukoencephalopathy, Systemic lupus erythematosus, Lymphopenia
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-299804 (URN)10.1159/000444874 (DOI)000378535900010 ()27065427 (PubMedID)
Available from: 2016-07-27 Created: 2016-07-27 Last updated: 2017-11-28Bibliographically approved
Lourenco, F., Katsarogiannis, E., Berntsson, S. & Moraes-Fontes, M. F. (2015). Systemic Lupus Erythematous and Progressive Multifocal Leukoencephalopathy: focus on lymphopenia. Paper presented at 11th International Congress on Systemic Lupus Erythematosus, 2-6 September, 2015, Vienna, Austria. Clinical and Experimental Rheumatology, 33(3), S33-S33
Open this publication in new window or tab >>Systemic Lupus Erythematous and Progressive Multifocal Leukoencephalopathy: focus on lymphopenia
2015 (English)In: Clinical and Experimental Rheumatology, ISSN 0392-856X, E-ISSN 1593-098X, Vol. 33, no 3, p. S33-S33Article in journal, Meeting abstract (Other academic) Published
National Category
Rheumatology and Autoimmunity
Identifiers
urn:nbn:se:uu:diva-264926 (URN)000360421900121 ()
Conference
11th International Congress on Systemic Lupus Erythematosus, 2-6 September, 2015, Vienna, Austria
Note

Supplement: 90, Meeting Abstract: P4.22

Available from: 2015-11-02 Created: 2015-10-19 Last updated: 2017-12-01Bibliographically approved
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