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Ciba, Iris
Publications (10 of 11) Show all publications
Dahlbom, I., Lidström, M., Vilen, H., Andersson, K., Ciba, I., Kritikos, D. & Forslund, A. (2017). Daily Assessments of Perceived Sensations in Obese and Non-Obese Children/Adolescents Using a New Mobile Application. Acta Paediatrica, 106, 14-14
Open this publication in new window or tab >>Daily Assessments of Perceived Sensations in Obese and Non-Obese Children/Adolescents Using a New Mobile Application
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2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, p. 14-14Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
adolescents, hunger, obesity, mobile application, stress
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-366466 (URN)10.1111/apa.14093 (DOI)000440296300024 ()
Available from: 2018-11-21 Created: 2018-11-21 Last updated: 2018-11-21Bibliographically approved
Heu, V., Aigner, E., Bergsten, P., Cadamuro, J., Ciba, I., Dahlbom, M., . . . Daniel, W. (2017). Effect of Glucose Load on the Incretin Response (GLP-1) in obese Adolescents compared to the normal-weight Adolescents. Wiener Klinische Wochenschrift, 129(19-20), 736-736
Open this publication in new window or tab >>Effect of Glucose Load on the Incretin Response (GLP-1) in obese Adolescents compared to the normal-weight Adolescents
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2017 (English)In: Wiener Klinische Wochenschrift, ISSN 0043-5325, E-ISSN 1613-7671, Vol. 129, no 19-20, p. 736-736Article in journal, Meeting abstract (Other academic) Published
National Category
Clinical Medicine
Identifiers
urn:nbn:se:uu:diva-346838 (URN)000412462900028 ()
Available from: 2018-04-03 Created: 2018-04-03 Last updated: 2018-04-03Bibliographically approved
Forslund, A., Weghuber, D., Paulmichl, K., Zsoldos, F., Widhalm, K., Vheu, M. D., . . . Bergsten, P. (2017). Exenatide Once Weekly Reduces Weight, Liver Fat And 2-Hour Postprandial Glucose In Obese Adolescents. Acta Paediatrica, 106(470), 14-15
Open this publication in new window or tab >>Exenatide Once Weekly Reduces Weight, Liver Fat And 2-Hour Postprandial Glucose In Obese Adolescents
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2017 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, no 470, p. 14-15Article in journal, Meeting abstract (Other academic) Published
Place, publisher, year, edition, pages
John Wiley & Sons, 2017
Keywords
Pediatric obesity, reduced glucose tolerance, NAFLD, GLP-1 analog, Exenatide
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-366467 (URN)10.1111/apa.14093 (DOI)000440296300025 ()
Available from: 2018-11-21 Created: 2018-11-21 Last updated: 2018-11-21Bibliographically approved
Staaf, J., Labmayr, V., Paulmichl, K., Manell, H., Cen, J., Ciba, I., . . . Kullberg, J. (2017). Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity. Pancreas, 46(3), 358-365
Open this publication in new window or tab >>Pancreatic Fat Is Associated With Metabolic Syndrome and Visceral Fat but Not Beta-Cell Function or Body Mass Index in Pediatric Obesity
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2017 (English)In: Pancreas, ISSN 0885-3177, E-ISSN 1536-4828, Vol. 46, no 3, p. 358-365Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: Adolescents with obesity have increased risk of type 2 diabetes and metabolic syndrome (MetS). Pancreatic fat has been related to these conditions; however, little is known about associations in pediatric obesity. The present study was designed to explore these associations further.

METHODS: We examined 116 subjects, 90 with obesity. Anthropometry, MetS, blood samples, and oral glucose tolerance tests were assessed using standard techniques. Pancreatic fat fraction (PFF) and other fat depots were quantified using magnetic resonance imaging.

RESULTS: The PFF was elevated in subjects with obesity. No association between PFF and body mass index-standard deviation score (BMI-SDS) was found in the obesity subcohort. Pancreatic fat fraction correlated to Insulin Secretion Sensitivity Index-2 and Homeostatic Model Assessment of Insulin Resistance in simple regression; however, when using adjusted regression and correcting for BMI-SDS and other fat compartments, PFF correlated only to visceral adipose tissue and fasting glucose. Highest levels of PFF were found in subjects with obesity and MetS.

CONCLUSIONS: In adolescents with obesity, PFF is elevated and associatedto MetS, fasting glucose, and visceral adipose tissue but not to beta-cellfunction, glucose tolerance, or BMI-SDS. This study demonstrates thatconclusions regarding PFF and its associations depend on the body massfeatures of the cohort.

Keywords
pancreatic fat, pediatric obesity, beta-cell function, metabolic syndrome, body mass index-standard deviation score
National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-311308 (URN)10.1097/MPA.0000000000000771 (DOI)000394448600018 ()27941426 (PubMedID)
Funder
Swedish Research Council, 72X-14019 2012-2330 2011-4423Swedish Diabetes AssociationEU, FP7, Seventh Framework Programme, 279153
Note

De två första författarna delar förstaförfattarskapet.

Available from: 2016-12-22 Created: 2016-12-22 Last updated: 2017-04-26Bibliographically approved
Manell, H., Staaf, J., Manukyan, L., Kristinsson, H., Cen, J., Stenlid, R., . . . Bergsten, P. (2016). Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes. Journal of Clinical Endocrinology and Metabolism, 101(3), 1181-1189
Open this publication in new window or tab >>Altered Plasma Levels of Glucagon, GLP-1 and Glicentin During OGTT in Adolescents With Obesity and Type 2 Diabetes
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2016 (English)In: Journal of Clinical Endocrinology and Metabolism, ISSN 0021-972X, E-ISSN 1945-7197, Vol. 101, no 3, p. 1181-1189Article in journal (Refereed) Published
Abstract [en]

CONTEXT: Proglucagon-derived hormones are important for glucose metabolism, but little is known about them in pediatric obesity and type 2 diabetes mellitus (T2DM).

OBJECTIVE: Fasting and postprandial levels of proglucagon-derived peptides glucagon, GLP-1, and glicentin in adolescents with obesity across the glucose tolerance spectrum were investigated.

DESIGN: This was a cross-sectional study with plasma hormone levels quantified at fasting and during an oral glucose tolerance test (OGTT).

SETTING: This study took place in a pediatric obesity clinic at Uppsala University Hospital, Sweden.

PATIENTS AND PARTICIPANTS: Adolescents with obesity, age 10-18 years, with normal glucose tolerance (NGT, n = 23), impaired glucose tolerance (IGT, n = 19), or T2DM (n = 4) and age-matched lean adolescents (n = 19) were included.

MAIN OUTCOME MEASURES: Outcome measures were fasting and OGTT plasma levels of insulin, glucagon, active GLP-1, and glicentin.

RESULTS: Adolescents with obesity and IGT had lower fasting GLP-1 and glicentin levels than those with NGT (0.25 vs 0.53 pM, P < .05; 18.2 vs 23.6 pM, P < .01) and adolescents with obesity and T2DM had higher fasting glucagon levels (18.1 vs 10.1 pM, P < .01) than those with NGT. During OGTT, glicentin/glucagon ratios were lower in adolescents with obesity and NGT than in lean adolescents (P < .01) and even lower in IGT (P < .05) and T2DM (P < .001).

CONCLUSIONS: Obese adolescents with IGT have lowered fasting GLP-1 and glicentin levels. In T2DM, fasting glucagon levels are elevated, whereas GLP-1 and glicentin levels are maintained low. During OGTT, adolescents with obesity have more products of pancreatically than intestinally cleaved proglucagon (ie, more glucagon and less GLP-1) in the plasma. This shift becomes more pronounced when glucose tolerance deteriorates.

National Category
Endocrinology and Diabetes
Identifiers
urn:nbn:se:uu:diva-292749 (URN)10.1210/jc.2015-3885 (DOI)000378811300051 ()26745255 (PubMedID)
Funder
VINNOVAEU, FP7, Seventh Framework Programme, 279153Swedish Diabetes Association, DIA 2013-043
Available from: 2016-05-09 Created: 2016-05-09 Last updated: 2019-03-28Bibliographically approved
Ciba, I., Eriksson, J., Ardelt-Gattinger, E., Hofmann, J., Weghuber, D., Dahlbom, M., . . . Forslund, A. (2016). Eating Behavior In Swedish And Austrian Children And Adolescents With Obesity. Acta Paediatrica, 106, 30-31
Open this publication in new window or tab >>Eating Behavior In Swedish And Austrian Children And Adolescents With Obesity
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2016 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 106, p. 30-31Article in journal (Refereed) Published
Keywords
eating behavior, obesity, pediatric, questionnaire, BMI-SDS
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-314805 (URN)000389948500022 ()
Available from: 2017-02-07 Created: 2017-02-06 Last updated: 2017-11-29Bibliographically approved
Paulmichl, K., Binder, S., Eidherr, A., Zsoldos, F., Widhalm, K., Bergsten, P., . . . Weghuber, D. (2015). Deep Subcutaneous Adipose Tissue Correlates with Accentuated Insulin Secretion and Poor Insulin Sensitivity in Obese Children and Adolescents. Acta Paediatrica, 104(S466), 2-3
Open this publication in new window or tab >>Deep Subcutaneous Adipose Tissue Correlates with Accentuated Insulin Secretion and Poor Insulin Sensitivity in Obese Children and Adolescents
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no S466, p. 2-3Article in journal, Meeting abstract (Other academic) Published
Keywords
childhood, insulin secretion, MRI, obesity, subcutaneous adipose tissue
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-267487 (URN)000362512600003 ()
Note

Meeting Abstract: OP02

Available from: 2015-12-14 Created: 2015-11-24 Last updated: 2017-12-01Bibliographically approved
Ciba, I., Weghuber, D., Manell, H., Staaf, J., Dahlbom, M., Paulmichl, K., . . . Forslund, A. (2015). Development of Glucose Intolerance in Obese Children Studied in the Beta-Judo Cohort. Acta Paediatrica, 104(S466), 12-12
Open this publication in new window or tab >>Development of Glucose Intolerance in Obese Children Studied in the Beta-Judo Cohort
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no S466, p. 12-12Article in journal, Meeting abstract (Other academic) Published
Keywords
diabetes, glucose tolerance, obesity, paediatric, BMI-SDS
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-267489 (URN)000362512600027 ()
Note

Meeting Abstract: CP08

Available from: 2015-12-14 Created: 2015-11-24 Last updated: 2017-12-01Bibliographically approved
Norgren, A., Ciba, I., Manell, H., Stenlid, R., Dahlbom, M., Bergsten, P. & Forslund, A. (2015). Early Adiposity Rebound and its Association with Obesity and Neuropsychiatric Disorders. Acta Paediatrica, 104(S466), 16-16
Open this publication in new window or tab >>Early Adiposity Rebound and its Association with Obesity and Neuropsychiatric Disorders
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no S466, p. 16-16Article in journal, Meeting abstract (Other academic) Published
Keywords
adiposity rebound, neuropsychiatry, obesity
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-267491 (URN)000362512600036 ()
Note

Meeting Abstract: PP20

Available from: 2015-12-14 Created: 2015-11-24 Last updated: 2017-12-01Bibliographically approved
Staaf, J., Labmayr, V., Paulmichl, K., Ohlsson, H., Cen, J., Ciba, I., . . . Kullberg, J. (2015). Pancreatic Fat is Associated with Metabolic Syndrome and Visceral Adipose Tissue but not Beta-Cell Function or Body Mass Index in Paediatric Obesity. Acta Paediatrica, 104(S466), 2-2
Open this publication in new window or tab >>Pancreatic Fat is Associated with Metabolic Syndrome and Visceral Adipose Tissue but not Beta-Cell Function or Body Mass Index in Paediatric Obesity
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2015 (English)In: Acta Paediatrica, ISSN 0803-5253, E-ISSN 1651-2227, Vol. 104, no S466, p. 2-2Article in journal, Meeting abstract (Other academic) Published
Keywords
childhood obesity, insulin sensitivity, metabolism, visceral fat
National Category
Pediatrics
Identifiers
urn:nbn:se:uu:diva-267488 (URN)000362512600002 ()
Note

Meeting Abstract: OP01

Available from: 2015-12-14 Created: 2015-11-24 Last updated: 2017-12-01Bibliographically approved
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