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Clapham, Eric
Publications (3 of 3) Show all publications
Clapham, E., Bodén, R., Brandt, L., Jonsson, E. G., Bahmanyar, S., Ekbom, A., . . . Reutfors, J. (2019). Suicide Ideation and Behavior as Risk Factors for Subsequent Suicide in Schizophrenia: A Nested Case-Control Study. Journal of Suicide and Life-threatening Behaviour, 49(4), 996-1005
Open this publication in new window or tab >>Suicide Ideation and Behavior as Risk Factors for Subsequent Suicide in Schizophrenia: A Nested Case-Control Study
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2019 (English)In: Journal of Suicide and Life-threatening Behaviour, ISSN 0363-0234, E-ISSN 1943-278X, Vol. 49, no 4, p. 996-1005Article in journal (Refereed) Published
Abstract [en]

Objective To investigate suicide ideation and behavior as risk factors for suicide in schizophrenia during varying time periods. Method Cases were 84 patients who died by suicide within 5 years from diagnosis in a source population of patients discharged for the first time from psychiatric hospitals in Stockholm County, Sweden, with a schizophrenia spectrum diagnosis. One control was individually matched with each suicide case. Data were retrieved from clinical records in a blind fashion. Thoughts of death, thoughts of suicide, suicide plan, and suicide attempt during varying time periods were investigated as risk factors for subsequent completed suicide. Results In adjusted analyses, thoughts of suicide, suicide plan, and suicide attempt were significantly associated with subsequent completed suicide in the following year. The highest suicide risk was found within a year following suicide attempt (adjusted OR 9.9, 95% confidence interval 2.5-39.0). The association between suicide ideation and behavior and subsequent suicide declined over time. Conclusions Several types of suicide ideation and behavior were associated with suicide, and the association was stronger for suicidal behavior. The clinical significance of suicidal communication appears highest during the following month or/and year. Many suicides occurred without recorded short-term suicidal communication.

Place, publisher, year, edition, pages
WILEY, 2019
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-393627 (URN)10.1111/sltb.12499 (DOI)000480640600007 ()30073690 (PubMedID)
Available from: 2019-09-26 Created: 2019-09-26 Last updated: 2019-09-26Bibliographically approved
Reutfors, J., Clapham, E., Bahmanyar, S., Brandt, L., Jönsson, E. G., Ekbom, A., . . . Ösby, U. (2016). Suicide risk and antipsychotic side effects in schizophrenia: nested case-control study.. Human Psychopharmacology: Clinical and Experimental, 31(4), 341-345
Open this publication in new window or tab >>Suicide risk and antipsychotic side effects in schizophrenia: nested case-control study.
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2016 (English)In: Human Psychopharmacology: Clinical and Experimental, ISSN 0885-6222, E-ISSN 1099-1077, Vol. 31, no 4, p. 341-345Article in journal (Refereed) Published
Abstract [en]

OBJECTIVE: This study explores suicide risk in schizophrenia in relation to side effects from antipsychotic medication.

METHODS: Among patients with a first clinical discharge diagnosis of schizophrenia or schizoaffective disorder in Stockholm County between 1984 and 2000 (n = 4000), those who died by suicide within 5 years from diagnosis were defined as cases (n = 84; 54% male). For each case, one individually matched control was identified from the same population. Information on antipsychotic side effects, including extrapyramidal symptoms (EPS) and akathisia, as well as prescriptions of anticholinergic medication, was retrieved from clinical records in a blinded fashion. Adjusted odds ratios (aORs) with 95% confidence intervals (CIs) of the association between suicide and side effects as well as anticholinergic medication were estimated using conditional logistic regression.

RESULTS: A lower suicide risk was found in patients with a history of EPS (aOR 0.33, 95% CI 0.12-0.94). There was no statistically significant association between akathisia or anticholinergic medication use and the suicide risk.

CONCLUSIONS: A lower suicide risk identified among patients with EPS could potentially reflect higher antipsychotic adherence, exposure to higher dosage, or polypharmacy among these patients.

National Category
Medical and Health Sciences
Identifiers
urn:nbn:se:uu:diva-288908 (URN)10.1002/hup.2536 (DOI)000379939200010 ()27108775 (PubMedID)
Funder
Stockholm County CouncilSwedish Research Council, K2007-62X-15078-04-3, K2008-62P-20597-01-3
Available from: 2016-04-28 Created: 2016-04-28 Last updated: 2017-11-30Bibliographically approved
Reutfors, J., Bahmanyar, S., Brandt, L., Clapham, E., Jönsson, E. G., Boden, R., . . . Osby, U. (2015). Suicide Risk and Side Effects from Antipsychotics in Schizophrenia: A Nested Case-Control Study. Pharmacoepidemiology and Drug Safety, 24, 333-333
Open this publication in new window or tab >>Suicide Risk and Side Effects from Antipsychotics in Schizophrenia: A Nested Case-Control Study
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2015 (English)In: Pharmacoepidemiology and Drug Safety, ISSN 1053-8569, E-ISSN 1099-1557, Vol. 24, p. 333-333Article in journal, Meeting abstract (Other academic) Published
National Category
Psychiatry
Identifiers
urn:nbn:se:uu:diva-283011 (URN)000369980200574 ()
Available from: 2016-04-11 Created: 2016-04-08 Last updated: 2017-11-30Bibliographically approved
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