uu.seUppsala University Publications
Change search
Link to record
Permanent link

Direct link
BETA
Publications (10 of 11) Show all publications
Werr, G., Khaji, Z., Ohlin, M., Andersson, M., Klintberg, L., Searle, S., . . . Tenje, M. (2019). Integrated thin film resistive sensors for in situ temperature measurements in an acoustic trap. Journal of Micromechanics and Microengineering, 29(9), Article ID 095003.
Open this publication in new window or tab >>Integrated thin film resistive sensors for in situ temperature measurements in an acoustic trap
Show others...
2019 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 29, no 9, article id 095003Article in journal (Refereed) Published
Abstract [en]

This work presents an acoustic trap with integrated thin film sensors to monitor temperature variations during operation. The acoustic trap is wet-etched in glass with a thermally bonded glass lid and the thin-film sensors are integrated during fabrication. We evaluated the performance of the integrated temperature sensors and measured a temperature sensitivity of +/- 0.01 degrees C and confirmed that the read-out of the thin film sensors was not affected neither by the ionic conductivity of the solution nor the addition of microparticles into the acoustic trap. From the experiments we observed a temperature increase of the acoustic trap during operation as a result of the dissipative heating of the the piezoelectric element used to actuate the trap. We also showed that when external convective cooling was applied to the system, the temperature increase of the acoustic trap was higher than the temperature increase of the piezoelectric element itself. This shows the importance of using integrated temperature sensors in acoustic trapping to monitor the local environmental conditions.

Place, publisher, year, edition, pages
IOP PUBLISHING LTD, 2019
Keywords
acoustophoresis, integrated RTD, external TC, acoustic trap, glass chip
National Category
Other Electrical Engineering, Electronic Engineering, Information Engineering
Identifiers
urn:nbn:se:uu:diva-391278 (URN)10.1088/1361-6439/ab2ac8 (DOI)000476561400001 ()
Funder
Knut and Alice Wallenberg Foundation
Available from: 2019-08-22 Created: 2019-08-22 Last updated: 2019-08-22Bibliographically approved
Werr, G., Khaji, Z., Ohlin, M., Andersson, M., Klintberg, L., Searle, S., . . . Tenje, M. (2019). Integrated thin film resistive sensors for in situ temperature measurements in an acoustic trap. In: Acoustofluidics 2019: This annual meeting will be held in Twente, The Netherlands in 2019. This focused meeting is dedicated to exploring the science, engineering, and use of micro- to nanoscale acoustofluidics.. Paper presented at Acoustofluidics 2019, 25-28 August 2019, Enschede, Netherlands (pp. 140-141).
Open this publication in new window or tab >>Integrated thin film resistive sensors for in situ temperature measurements in an acoustic trap
Show others...
2019 (English)In: Acoustofluidics 2019: This annual meeting will be held in Twente, The Netherlands in 2019. This focused meeting is dedicated to exploring the science, engineering, and use of micro- to nanoscale acoustofluidics., 2019, p. 140-141Conference paper, Poster (with or without abstract) (Other academic)
Abstract [en]

This work presents an acoustic trap with integrated thin film sensors to monitor temperature variations during operation. The acoustic trap is wet-etched in glass with a thermally bonded glass lid and the thin-film sensors are integrated during fabrication. We evaluated the performance of the integrated temperature sensors and measured a temperature sensitivity of ±0.01 °C and confirmed that the read-out of the thin film sensors was not affected neither by the ionic conducitiviy of the solution nor the addition of microparticles into the acoustic trap. From the experiments we observed a temperature increase of the acoustic trap during operation as a result of the dissipative heating of the the piezoelectric element used to actuate the trap. We also showed that when external convective cooling was applied to the system, the temperature increase of the acoustic trap was higher than the temperature incresase of the piezoelectric element itself. This shows the importance of using integrated temperature sensors in acoustic trapping to monitor the environmental conditions.

Keywords
acoustophoresis, platinum RTD, external TC, integrated temperature sensor, thin film resistive sensor, acoustic trapping
National Category
Medical Laboratory and Measurements Technologies
Identifiers
urn:nbn:se:uu:diva-398685 (URN)
Conference
Acoustofluidics 2019, 25-28 August 2019, Enschede, Netherlands
Funder
Knut and Alice Wallenberg Foundation
Available from: 2019-12-09 Created: 2019-12-09 Last updated: 2019-12-09Bibliographically approved
Tenje, M., Fornell, A., Ohlin, M. & Nilsson, J. (2018). Particle Manipulation Methods in Droplet Microfluidics. Analytical Chemistry, 90(3), 1434-1443
Open this publication in new window or tab >>Particle Manipulation Methods in Droplet Microfluidics
2018 (English)In: Analytical Chemistry, ISSN 0003-2700, E-ISSN 1520-6882, Vol. 90, no 3, p. 1434-1443Article in journal (Refereed) Published
Abstract [en]

This Feature article describes the different particle manipulation techniques available in the droplet microfluidics tool-box to handle particles encapsulated inside droplets and to manipulate whole droplets. We address the advantages and disadvantages of the different techniques to guide new users.  

National Category
Analytical Chemistry Engineering and Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
urn:nbn:se:uu:diva-348921 (URN)10.1021/acs.analchem.7b01333 (DOI)000424730600002 ()29188994 (PubMedID)
Funder
Swedish Research Council, 621-2013-5920The Crafoord Foundation, 20130569
Available from: 2018-04-25 Created: 2018-04-25 Last updated: 2018-10-17Bibliographically approved
Fornell, A., Ohlin, M., Nilsson, J. & Tenje, M. (2017). A droplet unit operator for controlled particle switching and enrichment. In: : . Paper presented at Micro and Nanofluidics fundamentals and applications (Flow 17), Paris, France, July 3-5 2017.
Open this publication in new window or tab >>A droplet unit operator for controlled particle switching and enrichment
2017 (English)Conference paper, Oral presentation with published abstract (Refereed)
National Category
Engineering and Technology Medical Laboratory and Measurements Technologies
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
urn:nbn:se:uu:diva-335796 (URN)
Conference
Micro and Nanofluidics fundamentals and applications (Flow 17), Paris, France, July 3-5 2017
Funder
Swedish Research CouncilThe Crafoord Foundation
Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2017-12-29Bibliographically approved
Fornell, A., Ohlin, M., Garofalo, F., Nilsson, J. & Tenje, M. (2017). An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves. Biomicrofluidics, 11, Article ID 031101.
Open this publication in new window or tab >>An intra-droplet particle switch for droplet microfluidics using bulk acoustic waves
Show others...
2017 (English)In: Biomicrofluidics, ISSN 1932-1058, E-ISSN 1932-1058, Vol. 11, article id 031101Article in journal (Refereed) Published
Abstract [en]

To transfer cell- and bead-assays into droplet-based platforms typically requires the use of complex microfluidic circuits, which calls for methods to switch the direction of the encapsulated particles. We present a microfluidic chip where the combination of acoustic manipulation at two different harmonics and a trident-shaped droplet-splitter enables direction-switching of microbeads and yeast cells in droplet microfluidic circuits. At the first harmonic, the encapsulated particles exit the splitter in the center daughter droplets, while at the second harmonic, the particles exit in the side daughter droplets. This method holds promises for droplet-based assays where particle-positioning needs to be selectively controlled.

National Category
Biophysics Engineering and Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
urn:nbn:se:uu:diva-324306 (URN)10.1063/1.4984131 (DOI)000404340600001 ()28580044 (PubMedID)
Funder
Knut and Alice Wallenberg Foundation, 2012.0023Swedish Research Council, 621-2013-5920The Crafoord Foundation, 20130569
Available from: 2017-06-14 Created: 2017-06-14 Last updated: 2019-01-21Bibliographically approved
Fornell, A., Ohlin, M., Nilsson, J. & Tenje, M. (2017). An optimized droplet split designed for acoustic intra-droplet particle enrichment. In: : . Paper presented at 43rd International Conference on Micro and Nano Engineering (MNE 2017), Braga, Portugal, September 18-22 2017.
Open this publication in new window or tab >>An optimized droplet split designed for acoustic intra-droplet particle enrichment
2017 (English)Conference paper, Oral presentation with published abstract (Refereed)
Keywords
Acoustics, Droplet microfluidics, Microfabrication
National Category
Engineering and Technology Medical Laboratory and Measurements Technologies
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
urn:nbn:se:uu:diva-335784 (URN)
Conference
43rd International Conference on Micro and Nano Engineering (MNE 2017), Braga, Portugal, September 18-22 2017
Funder
Swedish Research CouncilThe Crafoord Foundation
Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2017-12-29Bibliographically approved
Ohlin, M., Fornell, A., Bruus, H. & Tenje, M. (2017). Improved positioning and detectability of microparticles in droplet microfluidics using two-dimensional acoustophoresis. Journal of Micromechanics and Microengineering, 27(8), Article ID 084002.
Open this publication in new window or tab >>Improved positioning and detectability of microparticles in droplet microfluidics using two-dimensional acoustophoresis
2017 (English)In: Journal of Micromechanics and Microengineering, ISSN 0960-1317, E-ISSN 1361-6439, Vol. 27, no 8, article id 084002Article in journal (Refereed) Published
Abstract [en]

We have fabricated a silicon-glass two-phase droplet microfluidic system capable of generating sub 100 µm-sized,   =  (74  ±  2) µm, spherical droplets at rates of up to hundreds of hertz. By implementing a two-dimensional (2D) acoustophoresis particle-positioning method, we show a fourfold improvement in both vertical and lateral particle positioning inside the droplets compared to unactuated operation. The efficiency of the system has been optimized by incorporating aluminum matching layers in the transducer design permitting biocompatible operational temperatures (<37 °C). Furthermore, by using acoustic actuation, (99.8  ±  0.4)% of all encapsulated microparticles can be detected compared to only (79.0  ±  5.1)% for unactuated operation. In our experiments we observed a strong ordering of the microparticles in distinct patterns within the droplet when using 2D acoustophoresis; to explain the origin of these patterns we simulated numerically the fluid flow inside the droplets and compared with the experimental findings.

National Category
Nano Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
urn:nbn:se:uu:diva-327204 (URN)10.1088/1361-6439/aa7967 (DOI)000415698300001 ()
Funder
The Crafoord Foundation, 20130569Carl Tryggers foundation , CTS14478Swedish Research Council, 612-2013-5920
Available from: 2017-08-07 Created: 2017-08-07 Last updated: 2018-02-26Bibliographically approved
Ohlin, M., Andersson, M., Klintberg, L., Hjort, K. & Tenje, M. (2017). In situ temperature monitoring during acoustophoresis using integrated thin film Pt temperature sensors. In: : . Paper presented at Acoustofluidics 2017, San Diego, USA, August 28-29 2017.
Open this publication in new window or tab >>In situ temperature monitoring during acoustophoresis using integrated thin film Pt temperature sensors
Show others...
2017 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Engineering and Technology Medical Laboratory and Measurements Technologies
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
urn:nbn:se:uu:diva-335786 (URN)
Conference
Acoustofluidics 2017, San Diego, USA, August 28-29 2017
Funder
Swedish Research CouncilThe Crafoord FoundationKnut and Alice Wallenberg Foundation
Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2017-12-29Bibliographically approved
Ohlin, M., Andersson, M., Klintberg, L., Hjort, K. & Tenje, M. (2017). Internal temperature sensing in an acoustophoretic glass chip. In: : . Paper presented at 28th Micromechanics and Microsystems Europe workshop (MME 2017), Uppsala, Sweden, August 23-25 2017.
Open this publication in new window or tab >>Internal temperature sensing in an acoustophoretic glass chip
Show others...
2017 (English)Conference paper, Poster (with or without abstract) (Refereed)
National Category
Engineering and Technology Medical Laboratory and Measurements Technologies
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
urn:nbn:se:uu:diva-335727 (URN)
Conference
28th Micromechanics and Microsystems Europe workshop (MME 2017), Uppsala, Sweden, August 23-25 2017
Available from: 2017-12-07 Created: 2017-12-07 Last updated: 2017-12-29Bibliographically approved
Ohlin, M., Fornell, A., Bruus, H. & Tenje, M. (2017). Using two-dimensional acoustophoresis for improved particle positioning in droplet microfluidics. In: : . Paper presented at Micro and Nanofluidics fundamentals and applications (Flow 17), Paris, France, July 3-5 2017.
Open this publication in new window or tab >>Using two-dimensional acoustophoresis for improved particle positioning in droplet microfluidics
2017 (English)Conference paper, Poster (with or without abstract) (Refereed)
Keywords
Acoustophoresis, Droplet microfluidics, Particle manipulation, Optical detection, Encapsulation
National Category
Engineering and Technology
Research subject
Engineering Science with specialization in Microsystems Technology
Identifiers
urn:nbn:se:uu:diva-335795 (URN)
Conference
Micro and Nanofluidics fundamentals and applications (Flow 17), Paris, France, July 3-5 2017
Funder
Swedish Research CouncilThe Crafoord FoundationKnut and Alice Wallenberg Foundation
Available from: 2017-12-11 Created: 2017-12-11 Last updated: 2017-12-29Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0002-7023-4772

Search in DiVA

Show all publications