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Veldwijk, Jorien
Publications (10 of 18) Show all publications
Molema, C., Veldwijk, J., Wendel-Vos, W., de Wit, A., van de Goor, I. & Schuit, J. (2019). Chronically ill patients' preferences for a financial incentive in a lifestyle intervention. Results of a discrete choice experiment. PLoS ONE, 14(7), Article ID e0219112.
Open this publication in new window or tab >>Chronically ill patients' preferences for a financial incentive in a lifestyle intervention. Results of a discrete choice experiment
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2019 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 7, article id e0219112Article in journal (Refereed) Published
Abstract [en]

Background The preferences of diabetes type 2 patients and cardiovascular disease patients for a financial incentive added to a specified combined lifestyle intervention were investigated. Methods A discrete choice experiment questionnaire was filled out by 290 diabetes type 2 patients (response rate 29.9%). Panel-mixed-logit models were used to estimate the preferences for a financial incentive. Potential uptake rates of different financial incentives and relative importance scores of the included attributes were estimated. Included attributes and levels were: form of the incentive (cash money and different types of vouchers), value of the incentive (ranging from 15 to 100 euros), moment the incentive is received (start, halfway, after finishing the intervention) and prerequisite for receiving the incentive (registration, attendance or results at group or individual level). Results Prerequisites for receiving the financial incentive were the most important attribute, according to the respondents. Potential uptake rates for different financial incentives ranged between 37.9% and 58.8%. The latter uptake rate was associated with a financial incentive consisting of cash money with a value of (sic)100 that is handed out after completing the lifestyle program with the prerequisite that the participant attended at least 75% of the scheduled meetings. Conclusions The potential uptake of the different financial incentives varied between 37.9% and 58.8%. The value of the incentive does not significantly influence the potential uptake. However, the potential uptake and associated potential effect of the financial incentive is influenced by the type of financial incentive. The preferred type of incentive is (sic)100 in cash money, awarded after completing the lifestyle program if the participant attended at least 75% of the scheduled meetings.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE, 2019
National Category
Economics
Identifiers
urn:nbn:se:uu:diva-394651 (URN)10.1371/journal.pone.0219112 (DOI)000484977900009 ()31344135 (PubMedID)
Available from: 2019-10-16 Created: 2019-10-16 Last updated: 2019-10-16Bibliographically approved
van Overbeeke, E., Janssens, R., Whichello, C., Schölin Bywall, K., Sharpe, J., Nikolenko, N., . . . Huys, I. (2019). Design, Conduct, and Use of Patient Preference Studies in the Medical Product Life Cycle: A Multi-Method Study. Frontiers in Pharmacology, 10(1395)
Open this publication in new window or tab >>Design, Conduct, and Use of Patient Preference Studies in the Medical Product Life Cycle: A Multi-Method Study
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2019 (English)In: Frontiers in Pharmacology, ISSN 1663-9812, E-ISSN 1663-9812, Vol. 10, no 1395Article in journal (Refereed) Published
Abstract [en]

Objectives: To investigate stakeholder perspectives on how patient preference studies (PPS) should be designed and conducted to allow for inclusion of patient preferences in decision-making along the medical product life cycle (MPLC), and how patient preferences can be used in such decision-making.

Methods: Two literature reviews and semi-structured interviews (n = 143) with healthcare stakeholders in Europe and the US were conducted; results of these informed the design of focus group guides. Eight focus groups were conducted with European patients, industry representatives and regulators, and with US regulators and European/Canadian health technology assessment (HTA) representatives. Focus groups were analyzed thematically using NVivo.

Results: Stakeholder perspectives on how PPS should be designed and conducted were as follows: 1) study design should be informed by the research questions and patient population; 2) preferred treatment attributes and levels, as well as trade-offs among attributes and levels should be investigated; 3) the patient sample and method should match the MPLC phase; 4) different stakeholders should collaborate; and 5) results from PPS should be shared with relevant stakeholders. The value of patient preferences in decision-making was found to increase with the level of patient preference sensitivity of decisions on medical products. Stakeholders mentioned that patient preferences are hardly used in current decision-making. Potential applications for patient preferences across industry, regulatory and HTA processes were identified. Four applications seemed most promising for systematic integration of patient preferences: 1) benefit-risk assessment by industry and regulators at the marketing-authorization phase; 2) assessment of major contribution to patient care by European regulators; 3) cost-effectiveness analysis; and 4) multi criteria decision analysis in HTA.

Conclusions: The value of patient preferences for decision-making depends on the level of collaboration across stakeholders; the match between the research question, MPLC phase, sample, and preference method used in PPS; and the sensitivity of the decision regarding a medical product to patient preferences. Promising applications for patient preferences should be further explored with stakeholders to optimize their inclusion in decision-making.

Keywords
patient preferences, medical products, decision-making, health technology assessment, marketing authorization
National Category
Social and Clinical Pharmacy
Identifiers
urn:nbn:se:uu:diva-398215 (URN)10.3389/fphar.2019.01395 (DOI)000505681700001 ()31849657 (PubMedID)
Projects
IMI-PREFER
Note

Jorien Veldwijk and Isabelle Huys share last authorship.

Available from: 2019-12-03 Created: 2019-12-03 Last updated: 2020-01-28Bibliographically approved
Veldwijk, J., Groothuis-Oudshoorn, C. G. M., Kihlbom, U., Langenskiöld, S., Dekker, E., Kallenberg, F. G. J., . . . Lambooij, M. S. (2019). How psychological distance of a study sample in discrete choice experiments affects preference measurement: a colorectal cancer screening case study. Patient Preference and Adherence, 13, 273-282
Open this publication in new window or tab >>How psychological distance of a study sample in discrete choice experiments affects preference measurement: a colorectal cancer screening case study
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2019 (English)In: Patient Preference and Adherence, ISSN 1177-889X, E-ISSN 1177-889X, Vol. 13, p. 273-282Article in journal (Refereed) Published
Abstract [en]

Purpose: The purpose of this study was to investigate to what extent the outcomes of a discrete choice experiment (DCE) differ based on respondents' psychological distance to the decision at hand. Methods: A DCE questionnaire regarding individuals' preferences for genetic screening for colorectal cancer (CRC) within the Dutch national CRC screening program was created. The DCE contained nine D-efficient designed choice tasks and was distributed among two populations that differ in their psychological distance to the decision at hand: 1) a representative sample of the Dutch general population aged 55-65 years, and 2) a sample of Dutch individuals who attended an information appointment regarding colonoscopies following the detection of blood in their stool sample in the CRC screening program. The DCE consisted of four attributes related to the decision whether to participate in genetic screening for CRC: 1) risk of being genetically predisposed, 2) risk of developing CRC, 3) frequency of follow-up colonoscopies, and 4) survival. Direct attribute ranking, dominant decision-making behavior, and relative importance scores (based on panel MIXL) were compared between the two populations. Attribute level estimates were compared with the Swait and Louviere test. Results: The proportion of respondents who both ranked survival as the most important attribute, and showed dominant decision-making behavior for this attribute, was significantly higher in the screened population compared to the general population. The relative importance scores of the attributes significantly differed between populations. Finally, the Swait and Louviere test also revealed significant differences in attribute level estimates in both the populations. Conclusion: The study outcomes differed between populations depending on their psychological distance to the decision. This study shows the importance of adequate sample selection; therefore, it is advocated to increase attention to study sample selection and reporting in DCE studies.

Place, publisher, year, edition, pages
DOVE MEDICAL PRESS LTD, 2019
Keywords
discrete choice experiment, preferences, stated preferences, sample, psychological distance, genetic screening
National Category
Health Care Service and Management, Health Policy and Services and Health Economy
Identifiers
urn:nbn:se:uu:diva-377980 (URN)10.2147/PPA.S180994 (DOI)000458900800001 ()
Available from: 2019-03-04 Created: 2019-03-04 Last updated: 2019-03-04Bibliographically approved
Schölin Bywall, K., Veldwijk, J., Hansson, M. G. & Kihlbom, U. (2019). Patient Perspectives on the Value of Patient Preference Information in Regulatory Decision Making: A Qualitative Study in Swedish Patients with Rheumatoid Arthritis. Patient, 12(3), 297-305
Open this publication in new window or tab >>Patient Perspectives on the Value of Patient Preference Information in Regulatory Decision Making: A Qualitative Study in Swedish Patients with Rheumatoid Arthritis
2019 (English)In: Patient, ISSN 1178-1653, E-ISSN 1178-1661, Vol. 12, no 3, p. 297-305Article in journal (Refereed) Published
Abstract [en]

Background

There is increasing interest in involving patient preferences for benefits and risks in regulatory decision making. Therefore, it is essential to identify patient perspectives regarding the value of patient preference information (PPI).

Objectives

The aim of this study was to explore how patients with rheumatoid arthritis (RA) value the use of PPI in regulatory decision making regarding medical products.

Methods

Regulators and patients with RA were interviewed to gather initial insights into opinions on the use of PPI in regulatory decisions regarding medical products. The interviews were used to draft and validate the interview guide for focus groups with patients with RA. Participants were purposively sampled in collaboration with the Swedish Rheumatism Association in Stockholm and Uppsala. Each focus group consisted of three to six patients (18 in total). All interviews were audio-recorded, transcribed verbatim, and analysed using content analysis.

Results

According to the participants, PPI could lead to regulators considering patients’ needs, lifestyles and well-being when making decisions. PPI was important in all stages of the medical product lifecycle. Participants reported that, when participating in a preference study, it is important to be well-informed about the use of the study and the development, components, administration, and risks related to the medical products.

Conclusions

Patients thought PPI could be valuable to consider in regulatory decisions. It is essential for patients to be well-informed when asked for their preferences. Research on information materials to inform patients in preference studies is needed to increase the value of PPI in regulatory decision making.

National Category
Medical Ethics
Identifiers
urn:nbn:se:uu:diva-366354 (URN)10.1007/s40271-018-0344-2 (DOI)000468375300003 ()30443897 (PubMedID)
Funder
Riksbankens Jubileumsfond, M13-0260:1
Available from: 2018-11-20 Created: 2018-11-20 Last updated: 2019-06-24Bibliographically approved
Viberg, J., Langenskiöld, S., Segerdahl, P., Hansson, M. G., Hösterey, U. U., Gummesson, A. & Veldwijk, J. (2019). Research participants' preferences for receiving genetic risk information: a discrete choice experiment. Genetics in Medicine, 21(10), 2381-2389
Open this publication in new window or tab >>Research participants' preferences for receiving genetic risk information: a discrete choice experiment
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2019 (English)In: Genetics in Medicine, ISSN 1098-3600, E-ISSN 1530-0366, Vol. 21, no 10, p. 2381-2389Article in journal (Refereed) Published
Abstract [en]

Purpose: This study aims to determine research participants’ preferences for receiving genetic risk information when participating in a scientific study that uses genome sequencing.

Methods: A discrete choice experiment questionnaire was sent to 650 research participants (response rate 60.5%). Four attributes were selected for the questionnaire: type of disease, disease penetrance probability, preventive opportunity, and effectiveness of the preventive measure. Panel mixed logit models were used to determine attribute level estimates and the heterogeneity in preferences. Relative importance of the attribute and the predicted uptake for different information scenarios were calculated from the estimates. In addition, this study estimates predicted uptake for receiving genetic risk information in different scenarios.

Results: All characteristics influenced research participants’ willingness to receive genetic risk information. The most important characteristic was the effectiveness of the preventive opportunity. Predicted uptake ranged between 28% and 98% depending on what preventive opportunities and levels of effectiveness were presented.

Conclusion: Information about an effective preventive measure was most important for participants. They valued that attribute twice as much as the other attributes. Therefore, when there is an effective preventive measure, risk communication can be less concerned with the magnitude of the probability of developing disease.

 

Keywords
secondary findings, incidental findings, genetic risk information, research participants, preferences for genetic risk information
National Category
Public Health, Global Health, Social Medicine and Epidemiology Medical Genetics
Identifiers
urn:nbn:se:uu:diva-385799 (URN)10.1038/s41436-019-0511-4 (DOI)000488530100028 ()30992550 (PubMedID)
Funder
Riksbankens Jubileumsfond, PR2013-0123EU, FP7, Seventh Framework Programme, 305444Swedish Research CouncilSwedish Heart Lung Foundation
Available from: 2019-06-17 Created: 2019-06-17 Last updated: 2019-10-30Bibliographically approved
Grauman, Å., Hansson, M. G., Puranen, A., James, S. & Veldwijk, J. (2019). Short-term mental distress in research participants after receiving cardiovascular risk information. PLoS ONE, 14(5), Article ID e0217247.
Open this publication in new window or tab >>Short-term mental distress in research participants after receiving cardiovascular risk information
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2019 (English)In: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 14, no 5, article id e0217247Article in journal (Refereed) Published
Abstract [en]

BACKGROUND: Understanding of how cardiovascular risk information influence individuals is critical for the practice of risk assessment and the management of patients with cardiovascular disease.

OBJECTIVES: The objective of this study was to investigate change in mental distress among research participants after undergoing a cardiovascular risk assessment and receiving individual test results.

METHODS: In 2017, a questionnaire measuring mental distress after taking part in a risk assessment was distributed among 615 participants in the Swedish Cardiopulmonary Bio Image Study in Uppsala, Sweden, aged 50-64 years. Outcome measures were re-assessed after three months (30% were lost to follow-up).

RESULTS: There were no differences in outcomes after three months for participants with normal test results or for participants who were referred to primary health care. Mental distress increased in participants who were referred to the hospital, and were further explained by the fact that these participants were diagnosed with coronary artery stenosis.

CONCLUSIONS: CV risk information can be provided to individuals with lower levels of risk without concerns of inducing mental distress. However, in order to prevent unnecessary worry in contexts similar to this study, one should be prepared for different risk outcomes and plan for support for individuals with higher risk. The increased utility of powerful, yet not fully mature, imaging techniques requires careful considerations extending beyond medical risks and benefits; the clinician must also take into account the risk of mental distress and secure support when necessary.

Place, publisher, year, edition, pages
PUBLIC LIBRARY SCIENCE, 2019
Keywords
cardiovascular risk information, mental distress, health examinations, research participants
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-384225 (URN)10.1371/journal.pone.0217247 (DOI)000468865700025 ()31125371 (PubMedID)
Funder
Swedish Heart Lung Foundation
Available from: 2019-05-31 Created: 2019-05-31 Last updated: 2019-06-24Bibliographically approved
Russo, S., Jongerius, C., Faccio, F., Pizzoli, S. F. .., Pinto, C. A., Veldwijk, J., . . . Pravettoni, G. (2019). Understanding Patients' Preferences: A Systematic Review of Psychological Instruments Used in Patients' Preference and Decision Studies. Value in Health, 22(4), 491-501
Open this publication in new window or tab >>Understanding Patients' Preferences: A Systematic Review of Psychological Instruments Used in Patients' Preference and Decision Studies
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2019 (English)In: Value in Health, ISSN 1098-3015, E-ISSN 1524-4733, Vol. 22, no 4, p. 491-501Article, review/survey (Refereed) Published
Abstract [en]

Background

Research has been mainly focused on how to elicit patient preferences, with less attention on why patients form certain preferences.

Objectives

To assess which psychological instruments are currently used and which psychological constructs are known to have an impact on patients' preferences and health-related decisions including the formation of preferences and preference heterogeneity.

Methods

A systematic database search was undertaken to identify relevant studies. From the selected studies, the following information was extracted: study objectives, study population, design, psychological dimensions investigated, and instruments used to measure psychological variables.

Results

Thirty-three studies were identified that described the association between a psychological construct, measured using a validated instrument, and patients' preferences or health-related decisions. We identified 33 psychological instruments and 18 constructs, and categorized the instruments into 5 groups, namely, motivational factors, cognitive factors, individual differences, emotion and mood, and health beliefs.

Conclusions

This review provides an overview of the psychological factors and related instruments in the context of patients' preferences and decisions in healthcaresettings. Our results indicate that measures of health literacy, numeracy, and locus of control have an impact on health-related preferences and decisions. Within the category of constructs that could explain preference and decision heterogeneity, health locus of control is a strong predictor of decisions in several healthcare contexts and is useful to consider when designing a patient preference study. Future research should continue to explore the association of psychological constructs with preference formation and heterogeneity to build on these initial recommendations.

Keywords
decision making, instruments, measurements, patient preference, psychological variables, stated preferences
National Category
Pharmaceutical Sciences
Research subject
Social Pharmacy
Identifiers
urn:nbn:se:uu:diva-381724 (URN)10.1016/j.jval.2018.12.007 (DOI)000463876900014 ()30975401 (PubMedID)
Projects
IMI-PREFER
Funder
EU, Horizon 2020, 115966
Available from: 2019-04-12 Created: 2019-04-12 Last updated: 2019-05-03Bibliographically approved
van Overbeeke, E., Whichello, C., Janssens, R., Veldwijk, J., Cleemput, I., Simoens, S., . . . Huys, I. (2018). Factors and situations influencing the value of patient preference studies along the medical product lifecycle: a literature review. Drug Discovery Today
Open this publication in new window or tab >>Factors and situations influencing the value of patient preference studies along the medical product lifecycle: a literature review
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2018 (English)In: Drug Discovery Today, ISSN 1359-6446, E-ISSN 1878-5832Article in journal (Refereed) In press
Abstract [en]

Industry, regulators, health technology assessment (HTA) bodies, and payers are exploring the use of patient preferences in their decision-making processes. In general, experience in conducting and assessing patient preference studies is limited. Here, we performed a systematic literature search and review to identify factors and situations influencing the value of patient preference studies, as well as applications throughout the medical product lifecyle. Factors and situations identified in 113 publications related to the organization, design, and conduct of studies, and to communication and use of results. Although current use of patient preferences is limited, we identified possible applications in discovery, clinical development, marketing authorization, HTA, and postmarketing phases.

Keywords
patient preferences, drugs, drug development, medical devices, medical device development
National Category
Pharmaceutical Sciences
Research subject
Social Pharmacy
Identifiers
urn:nbn:se:uu:diva-361643 (URN)10.1016/j.drudis.2018.09.015 (DOI)
Projects
IMI-PREFER
Available from: 2018-09-26 Created: 2018-09-26 Last updated: 2018-10-04Bibliographically approved
Ancillotti, M., Eriksson, S., Veldwijk, J., Nihlén Fahlquist, J., Andersson, D. I. & Godskesen, T. (2018). Public awareness and individual responsibility needed for judicious use of antibiotics: a qualitative study of public beliefs and perceptions. BMC Public Health, 18(1), Article ID 1153.
Open this publication in new window or tab >>Public awareness and individual responsibility needed for judicious use of antibiotics: a qualitative study of public beliefs and perceptions
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2018 (English)In: BMC Public Health, ISSN 1471-2458, E-ISSN 1471-2458, Vol. 18, no 1, article id 1153Article in journal (Refereed) Published
Abstract [en]

Background

High consumption of antibiotics has been identified as an important driver for the increasing antibiotic resistance, considered to be one of the greatest threats to public health globally. Simply informing the public about this consequence is insufficient to induce behavioral change. This study explored beliefs and perceptions among Swedes, with the aim of identifying factors promoting and hindering a judicious approach to antibiotics use. The study focused primarily on the medical use of antibiotics, also considering other aspects connected with antibiotic resistance, such as travelling and food consumption.

Methods

Data were collected through focus group discussions at the end of 2016. Twenty-three Swedes were recruited using an area-based approach and purposive sampling, aiming for as heterogeneous groups as possible regarding gender (13 women, 10 men), age (range 20–81, mean 38), and education level. Interview transcripts were analyzed using qualitative content analysis. The Health Belief Model was used as a theoretical framework.

Results

Antibiotic resistance was identified by participants as a health threat with the potential for terrible consequences. The severity of the problem was perceived more strongly than the actual likelihood of being affected by it. Metaphors such as climate change were abundantly employed to describe antibiotic resistance as a slowly emerging problem. There was a tension between individual (egoistic) and collective (altruistic) reasons for engaging in judicious behavior. The individual effort needed and antibiotics overprescribing were considered major barriers to such behavior. In their discussions, participants stressed the need for empowerment, achieved through good health communication from authorities and family physicians.

Conclusions

Knowledge about antibiotic consumption and resistance, as well as values such as altruism and trust in the health care system, has significant influence on both perceptions of individual responsibility and on behavior. This suggests that these factors should be emphasized in health education and health promotion. To instead frame antibiotic resistance as a slowly emerging disaster, risks diminish the public perception of being susceptible to it.

Place, publisher, year, edition, pages
BioMed Central, 2018
Keywords
Antibiotic resistance, health belief model, health behavior, qualitative research, Sweden
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-362360 (URN)10.1186/s12889-018-6047-8 (DOI)000446405800003 ()30285689 (PubMedID)
Available from: 2018-10-03 Created: 2018-10-03 Last updated: 2018-12-04Bibliographically approved
de Bekker-Grob, E. W., Veldwijk, J., Jonker, M., Donkers, B., Huisman, J., Buis, S., . . . Bindels, P. (2018). The impact of vaccination and patient characteristics on influenza vaccination uptake of elderly people: A discrete choice experiment. Vaccine, 36(11), 1467-1476
Open this publication in new window or tab >>The impact of vaccination and patient characteristics on influenza vaccination uptake of elderly people: A discrete choice experiment
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2018 (English)In: Vaccine, ISSN 0264-410X, E-ISSN 1873-2518, Vol. 36, no 11, p. 1467-1476Article in journal (Refereed) Published
Abstract [en]

Objectives: To improve information for patients and to facilitate a vaccination coverage that is in line with the EU and World Health Organization goals, we aimed to quantify how vaccination and patient characteristics impact on influenza vaccination uptake of elderly people.

Methods: An online discrete choice experiment (DCE) was conducted among 1261 representatives of the Dutch general population aged 60 years or older. In the DCE, we used influenza vaccination scenarios based on five vaccination characteristics: effectiveness, risk of severe side effects, risk of mild side effects, protection duration, and absorption time. A heteroscedastic multinomial logit model was used, taking scale and preference heterogeneity (based on 19 patient characteristics) into account.

Results: Vaccination and patient characteristics both contributed to explain influenza vaccination uptake. Assuming a base case respondent and a realistic vaccination scenario, the predicted uptake was 58%. One-way changes in vaccination characteristics and patient characteristics changed this uptake from 46% up to 61% and from 37% up to 95%, respectively. The strongest impact on vaccination uptake was whether the patient had been vaccinated last year, whether s/he had experienced vaccination side effects, and the patient's general attitude towards vaccination.

Conclusions: Although vaccination characteristics proved to influence influenza vaccination uptake, certain patient characteristics had an even higher impact on influenza vaccination uptake. Policy makers and general practitioners can use these insights to improve their communication plans and information regarding influenza vaccination for individuals aged 60 years or older. For instance, physicians should focus more on patients who had experienced side effects due to vaccination in the past, and policy makers should tailor the standard information folder to patients who had been vaccinated last year and to patient who had not.

Keywords
Influenza vaccination, Vaccination characteristics, Patient characteristics, Discrete choice experiment, Vaccination uptake
National Category
Public Health, Global Health, Social Medicine and Epidemiology
Identifiers
urn:nbn:se:uu:diva-350621 (URN)10.1016/j.vaccine.2018.01.054 (DOI)000427212900020 ()29426662 (PubMedID)
Available from: 2018-05-22 Created: 2018-05-22 Last updated: 2018-05-22Bibliographically approved
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