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Publications (10 of 14) Show all publications
Tan, X., van Egmond, L., Partinen, M., Lange, T. & Benedict, C. (2019). A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients. Sleep Medicine, 59, 42-50
Open this publication in new window or tab >>A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients
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2019 (English)In: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 59, p. 42-50Article, review/survey (Refereed) Published
Abstract [en]

Sleep and circadian disruptions are frequently observed in patients across hospital wards. This is alarming, since impaired nocturnal sleep and disruption of a normal circadian rhythm can compromise health and disturb processes involved in recovery from illness (eg, immune functions). With this in mind, the present narrative review discusses how patient characteristics (sleep disorders, anxiety, stress, chronotype, and disease), hospital routines (pain management, timing of medication, nocturnal vital sign monitoring, and physical inactivity), and hospital environment (light and noise) may all contribute to sleep disturbances and circadian misalignment in patients. We also propose hospital-based strategies that may help reduce sleep and circadian disruptions in patients admitted to the hospital. (C) 2018 The Authors. Published by Elsevier B.V.

Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2019
Keywords
Sleep, Circadian rhythm, Hospital, Inpatients
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-390001 (URN)10.1016/j.sleep.2018.08.007 (DOI)000471665700006 ()30415906 (PubMedID)
Funder
Swedish Research Council, 2015-03100Novo Nordisk, NNF14OC0009349The Swedish Brain Foundation, FO2016-009Ernfors FoundationÅke Wiberg Foundation, M17-0088Fredrik och Ingrid Thurings Stiftelse, 2017-00313
Available from: 2019-08-05 Created: 2019-08-05 Last updated: 2019-08-05Bibliographically approved
Dyakova, O., Rångtell, F. H., Tan, X., Nordström, K. & Benedict, C. (2019). Acute sleep loss induces signs of visual discomfort in young men. Journal of Sleep Research, 28(6), Article ID e12837.
Open this publication in new window or tab >>Acute sleep loss induces signs of visual discomfort in young men
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2019 (English)In: Journal of Sleep Research, ISSN 0962-1105, E-ISSN 1365-2869, Vol. 28, no 6, article id e12837Article in journal (Refereed) Published
Abstract [en]

Acute sleep loss influences visual processes in humans, such as recognizing facial emotions. However, to the best of our knowledge, no study till date has examined whether acute sleep loss alters visual comfort when looking at images. One image statistic that can be used to investigate the level of visual comfort experienced under visual encoding is the slope of the amplitude spectrum, also referred to as the slope constant. The slope constant describes the spatial distribution of pixel intensities and deviations from the natural slope constant can induce visual discomfort. In the present counterbalanced crossover design study, 11 young men with normal or corrected-to-normal vision participated in two experimental conditions: one night of sleep loss and one night of sleep. In the morning after each intervention, subjects performed a computerized psychophysics task. Specifically, they were required to adjust the slope constant of images depicting natural landscapes and close-ups with a randomly chosen initial slope constant until they perceived each image as most natural looking. Subjects also rated the pleasantness of each selected image. Our analysis showed that following sleep loss, higher slope constants were perceived as most natural looking when viewing images of natural landscapes. Images with a higher slope constant are generally perceived as blurrier. The selected images were also rated as less pleasant after sleep loss. No such differences between the experimental conditions were noted for images of close-ups. The results suggest that sleep loss induces signs of visual discomfort in young men. Possible implications of these findings are discussed.

Keywords
aesthetical pleasantness, amplitude spectrum, natural scene statistics, psychophysics, total sleep deprivation
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-380990 (URN)10.1111/jsr.12837 (DOI)000495679200026 ()30815934 (PubMedID)
Funder
Swedish Research Council, 2012-4740Swedish Research Council, 2015-03100Novo Nordisk, NNF14OC0009349
Available from: 2019-04-03 Created: 2019-04-03 Last updated: 2019-12-05Bibliographically approved
van Egmond, L., Tan, X., Sjögren, P., Cederholm, T. & Benedict, C. (2019). Association between Healthy Dietary Patterns and Self-Reported Sleep Disturbances in Older Men: The ULSAM Study. Nutrients, 11(5), Article ID 1029.
Open this publication in new window or tab >>Association between Healthy Dietary Patterns and Self-Reported Sleep Disturbances in Older Men: The ULSAM Study
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2019 (English)In: Nutrients, ISSN 2072-6643, E-ISSN 2072-6643, Vol. 11, no 5, article id 1029Article in journal (Refereed) Published
Abstract [en]

To date, little is known about how dietary patterns may link to measures of sleep quality in older subjects, who often suffer from sleep problems. Here, we investigated, in an older male population from Sweden (n = 970; aged 71 +/- 1 year), whether adherence to the Healthy Diet Indicator (HDI; based on recommendations from the World Health Organization) or the Mediterranean Diet (MD) is linked to sleep disturbances. The diet scores were calculated using a seven-day food diary, and self-reported sleep initiation or maintenance problems were assessed by questionnaires. When adjusted for potential confounders, no associations between dietary scores and sleep parameters were found. In contrast, low consumption of milk and dairy products one of the dietary features of the MD was associated with better subjective sleep initiation. This association was, however, not found in men with adequate reports of daily energy intake (similar to 54% of the cohort). To summarize, our findings do not suggest that older men can mitigate perceived difficulties to fall and stay asleep by adhering to either the HDI or MD. Whether low consumption of milk and dairy products can facilitate sleep initiation must be confirmed in future studies by utilizing objective measures of sleep such as polysomnography. Finally, when investigating associations between dietary patterns and sleep, particular attention should be paid to the potential confounder of inadequate reporting of energy intake.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
mediterranean diet, healthy diet indicator, sleep problems, elderly population, dietary adherence
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:uu:diva-389873 (URN)10.3390/nu11051029 (DOI)000471021600089 ()31071943 (PubMedID)
Funder
Swedish Research Council, 2015-03100Novo Nordisk, NNF14OC0009349The Swedish Brain FoundationÅke Wiberg Foundation, M17-0088Fredrik och Ingrid Thurings Stiftelse, 2017-00313Swedish Society for Medical Research (SSMF)
Available from: 2019-07-31 Created: 2019-07-31 Last updated: 2019-07-31Bibliographically approved
Tan, X., Titova, O. E., Lindberg, E., Elmståhl, S., Lind, L., Schiöth, H. B. & Benedict, C. (2019). Association Between Self-Reported Sleep Duration and Body Composition in Middle-Aged and Older Adults. Journal of Clinical Sleep Medicine (JCSM), 15(3), 431-435
Open this publication in new window or tab >>Association Between Self-Reported Sleep Duration and Body Composition in Middle-Aged and Older Adults
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2019 (English)In: Journal of Clinical Sleep Medicine (JCSM), ISSN 1550-9389, E-ISSN 1550-9397, Vol. 15, no 3, p. 431-435Article in journal (Refereed) Published
Abstract [en]

STUDY OBJECTIVES: The current study sought to examine whether self-reported sleep duration is linked to an adverse body composition in 19,709 adults aged 45 to 75 years.

METHODS: All variables used in the current study were derived from the Swedish EpiHealth cohort study. Habitual sleep duration was measured by questionnaires. Body composition was assessed by bioimpedance. The main outcome variables were fat mass and fat-free mass (in kg). Analysis of covariance adjusting for age, sex, fat mass in the case of fat-free mass (and vice versa), leisure time physical activity, smoking, and alcohol consumption was used to investigate the association between sleep duration and body composition.

RESULTS: Short sleep (defined as ≤ 5 hours sleep per day) and long sleep (defined as 8 or more hours of sleep per day) were associated with lower fat-free mass and higher fat mass, compared with 6 to 7 hours of sleep duration (P< .05).

CONCLUSIONS: These observations could suggest that both habitual short and long sleep may contribute to two common clinical phenotypes in middle-aged and older humans, ie, body adiposity and sarcopenia. However, the observational nature of our study does not allow for causal interpretation.

Keywords
body fat, elderly, fat-free mass, middle-aged, sleep
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-379286 (URN)10.5664/jcsm.7668 (DOI)000461417900009 ()30853046 (PubMedID)
Funder
Swedish Research CouncilNovo Nordisk, NNF14OC0009349Swedish Research Council, 2015-03100Ernfors FoundationÅke Wiberg Foundation, M17-0088Åke Wiberg Foundation, M18-0169Fredrik och Ingrid Thurings Stiftelse, 2017-00313Fredrik och Ingrid Thurings Stiftelse, 2018-00365
Available from: 2019-03-14 Created: 2019-03-14 Last updated: 2019-04-04Bibliographically approved
Tan, X., Ciuculete, D.-M., Schiöth, H. B. & Benedict, C. (2019). Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank. Journal of Internal Medicine
Open this publication in new window or tab >>Associations between chronotype, MTNR1B genotype and risk of type 2 diabetes in UK Biobank
2019 (English)In: Journal of Internal Medicine, ISSN 0954-6820, E-ISSN 1365-2796Article in journal (Refereed) Epub ahead of print
Abstract [en]

Objective

To examine the association between the MTNR1B G risk allele, type 2 diabetes (T2D) and chronotype in the UK Biobank.

Methods

Data from the baseline investigation of the UK Biobank were utilized (n = 337 083 White British; mean age: 56.9 years; 54% women). MTNR1B rs10830963 was directly genotyped [CC (reference group), CG and GG]. Chronotype was divided into four categories: definitely morning (reference group); more morning than evening; more evening than morning; and definitely evening. Logistic regression analyses were performed to estimate odds ratios and 95% confidence intervals (CIs) for T2D, controlling for age, sex and other confounders.

Results

Carriers of the rs10830963 risk allele had a higher risk of T2D [CG vs. CC: OR (95% CI) 1.10 (1.07, 1.15); GG vs. CC: 1.21 (1.14, 1.29)]. Compared with definitely morning chronotype, participants with definitely evening chronotype exhibited the highest risk of T2D [1.25 (1.17, 1.33)]. Despite a nonsignificant interaction between chronotype and the risk allele [0.98 (0.94, 1.01), P = 0.176 for interaction term], we found that definitely evening chronotype (vs. definitely morning) was linked with a higher risk of T2D amongst CC and CG but not GG carriers. Additionally, we saw that the GG genotype (vs. CC) was associated with a higher risk of T2D across all chronotype categories, except for definitely evening.

Conclusion

Our findings suggest that the MTNR1B G risk allele and late chronotype increase the risk of T2D. The association between late chronotype and higher risk of T2D appears to vary across MTNR1B rs10830963 genotypes.

Keywords
chronotype, genetic risk, melatonin receptor 1B polymorphism, type 2 diabetes, UK Biobank
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-397675 (URN)10.1111/joim.12994 (DOI)000494559800001 ()31623012 (PubMedID)
Funder
Swedish Research Council, 2015-03100
Available from: 2019-11-28 Created: 2019-11-28 Last updated: 2019-11-28Bibliographically approved
Tan, X., Cedernaes, J., Risérus, U. & Benedict, C. (2019). Lack of association between self-reported insomnia symptoms and clamp-derived insulin sensitivity in elderly men. Psychoneuroendocrinology, 102, 256-260
Open this publication in new window or tab >>Lack of association between self-reported insomnia symptoms and clamp-derived insulin sensitivity in elderly men
2019 (English)In: Psychoneuroendocrinology, ISSN 0306-4530, E-ISSN 1873-3360, Vol. 102, p. 256-260Article in journal (Refereed) Published
Abstract [en]

Insomnia-related sleep disruptions, such as short and disturbed sleep, have been tied to systemic insulin resistance in young adult populations. We therefore sought to confirm these findings in a cohort of elderly men. To this aim, we utilized variables from 980 men who participated in the investigation at age 70 of the Uppsala Longitudinal Study of Adult Men. Self-reported insomnia symptoms were assessed by questions about difficulty initiating sleep, early final awakening, and regular use of hypnotics. All participants also underwent the gold standard hyperinsulinemic-euglycemic clamp technique to assess the insulin sensitivity index (M/I). Finally, fasting blood was collected to measure free fatty acids (FFAs) and adiponectin. Differences in blood parameters between men with and those without insomnia were determined by ANCOVA, and were adjusted for lifestyle and cardio-metabolic risk factors. Our analysis yielded no differences in M/I, FFAs, and adiponectin between men with and those without insomnia symptoms. Analyses in non-diabetic and diabetic subsamples confirmed these negative findings. Our cross-sectional results therefore suggest that insomnia symptoms may have a minimal effect, if any, on measures of insulin sensitivity in elderly men. Given the observational design of our study, future studies are needed to determine whether experimental sleep manipulations influence systemic insulin sensitivity in elderly humans, as has previously been shown in young adult populations.

Place, publisher, year, edition, pages
PERGAMON-ELSEVIER SCIENCE LTD, 2019
Keywords
Male cohort, Insomnia symptoms, Clamp-derived insulin sensitivity, Adiponectin, Free fatty acids
National Category
Physiology
Identifiers
urn:nbn:se:uu:diva-382522 (URN)10.1016/j.psyneuen.2018.12.227 (DOI)000462800900032 ()30594818 (PubMedID)
Funder
Swedish Research Council, 2015-03100Novo Nordisk, NNF14OC0009349The Swedish Brain FoundationÅke Wiberg Foundation, M17-0088Fredrik och Ingrid Thurings Stiftelse, 2017-00313
Available from: 2019-04-29 Created: 2019-04-29 Last updated: 2019-04-29Bibliographically approved
Tan, X., van Egmond, L., Partinen, M., Lange, T. & Benedict, C. (2019). Response to comment on "A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients" [Letter to the editor]. Sleep Medicine, 59, 53-53
Open this publication in new window or tab >>Response to comment on "A narrative review of interventions for improving sleep and reducing circadian disruption in medical inpatients"
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2019 (English)In: Sleep Medicine, ISSN 1389-9457, E-ISSN 1878-5506, Vol. 59, p. 53-53Article in journal, Letter (Other academic) Published
Place, publisher, year, edition, pages
ELSEVIER SCIENCE BV, 2019
National Category
Neurology
Identifiers
urn:nbn:se:uu:diva-390002 (URN)10.1016/j.sleep.2018.10.002 (DOI)000471665700008 ()30553689 (PubMedID)
Available from: 2019-08-05 Created: 2019-08-05 Last updated: 2019-08-05Bibliographically approved
Tan, X., van Egmond, L., Chapman, C. D., Cedernaes, J. & Benedict, C. (2018). Aiding sleep in type 2 diabetes: therapeutic considerations. The Lancet Diabetes and Endocrinology, 6(1), 60-68
Open this publication in new window or tab >>Aiding sleep in type 2 diabetes: therapeutic considerations
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2018 (English)In: The Lancet Diabetes and Endocrinology, ISSN 2213-8587, E-ISSN 2213-8595, Vol. 6, no 1, p. 60-68Article, review/survey (Refereed) Published
Abstract [en]

Insomnia and obstructive sleep apnoea (OSA) are more prevalent in patients with type 2 diabetes than in the general population. Both insomnia and OSA have been linked to cardiometabolic alterations (eg, hypertension, increased activity of the sympathetic nervous system, and systemic insulin resistance) that can exacerbate the pathophysiology of type 2 diabetes. Improvement of sleep in patients with diabetes could therefore aid the treatment of diabetes. To help health practitioners choose the best clinical tool to improve their patients' sleep without detrimentally affecting glucose regulation, this Review critically analyses the effects of common treatments for insomnia and OSA on both sleep and glucose metabolism in patients with type 2 diabetes. These treatments include pharmaceutical sleep aids (eg, benzodiazepine receptor agonists, melatonin) and cognitive behavioural therapy for insomnia, continuous positive airway pressure for OSA, and lifestyle interventions.

National Category
Endocrinology and Diabetes Pharmacology and Toxicology
Identifiers
urn:nbn:se:uu:diva-342756 (URN)10.1016/S2213-8587(17)30233-4 (DOI)000423799900020 ()28844889 (PubMedID)
Funder
Novo NordiskSwedish Research CouncilAFA InsuranceSwedish Society of MedicineThe Swedish Brain FoundationÅke Wiberg FoundationLars Hierta Memorial Foundation
Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-05-08Bibliographically approved
Tan, X. & Benedict, C. (2018). Association between high-glycemic diet and cerebral amyloid burden: a possible role for sleep [Letter to the editor]. American Journal of Clinical Nutrition, 107(3), 480-480
Open this publication in new window or tab >>Association between high-glycemic diet and cerebral amyloid burden: a possible role for sleep
2018 (English)In: American Journal of Clinical Nutrition, ISSN 0002-9165, E-ISSN 1938-3207, Vol. 107, no 3, p. 480-480Article in journal, Letter (Other academic) Published
National Category
Nutrition and Dietetics
Identifiers
urn:nbn:se:uu:diva-356236 (URN)10.1093/ajcn/nqx073 (DOI)000427882800018 ()29566198 (PubMedID)
Available from: 2018-07-27 Created: 2018-07-27 Last updated: 2018-07-27Bibliographically approved
Tan, X., Chapman, C. D., Cedernaes, J. & Benedict, C. (2018). Association between long sleep duration and increased risk of obesity and type 2 diabetes: A review of possible mechanisms. Sleep Medicine Reviews, 40, 127-134
Open this publication in new window or tab >>Association between long sleep duration and increased risk of obesity and type 2 diabetes: A review of possible mechanisms
2018 (English)In: Sleep Medicine Reviews, ISSN 1087-0792, E-ISSN 1532-2955, Vol. 40, p. 127-134Article, review/survey (Refereed) Published
Abstract [en]

For the last two decades research has revealed an alarming association between short sleep duration and metabolic disorders. In tandem, the hormonal, behavioral, and genetic mechanisms underlying this relationship have been extensively investigated and reviewed. However, emerging evidence is revealing that excessive sleep duration has remarkably similar deleterious effects. Unfortunately, to date there has been little attention to what drives this connection. This narrative review therefore aims to summarize existing epidemiological findings, experimental work, and most importantly putative molecular and behavioral mechanisms connecting excessive sleep duration with both obesity and type 2 diabetes mellitus. It will also address recent findings suggesting a worrisome bidirectional effect such that metabolic disorders create a positive feedback loop which further perpetuates excessive sleep.

Keywords
Chronotype, Long sleep duration, Obesity, Positive feedback loop, Putative mechanisms, Type 2 diabetes mellitus
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-342958 (URN)10.1016/j.smrv.2017.11.001 (DOI)000438201300012 ()29233612 (PubMedID)
Funder
Novo Nordisk, NNF14OC0009349The Swedish Brain Foundation, FO2016-0092Swedish Research Council, 2015-03100
Available from: 2018-02-23 Created: 2018-02-23 Last updated: 2018-11-12Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0003-3992-5812

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