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Siwani, Samer
Publications (2 of 2) Show all publications
Siwani, S., Franca, A. S. C., Mikulovic, S., Reis, A., Hilscher, M. M., Edwards, S. J., . . . Kullander, K. (2018). OLM alpha 2 Cells Bidirectionally Modulate Learning. Neuron, 99(2), 404-412
Open this publication in new window or tab >>OLM alpha 2 Cells Bidirectionally Modulate Learning
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2018 (English)In: Neuron, ISSN 0896-6273, E-ISSN 1097-4199, Vol. 99, no 2, p. 404-412Article in journal (Refereed) Published
Abstract [en]

Inhibitory interneurons participate in mnemonic processes. However, defined roles for identified interneuron populations are scarce. A subpopulation of oriens lacunosum-moleculare (OLM) interneurons genetically defined by the expression of the nicotinic receptor alpha 2 subunit has been shown to gate information carried by either the temporoammonic pathway or Schaffer collaterals in vitro. Here we set out to determine whether selective modulation of OLM alpha 2 cells in the intermediate CA1 affects learning and memory in vivo. Our data show that intermediate OLM alpha 2 cells can either enhance (upon their inhibition) or impair (upon their activation) object memory encoding in freely moving mice, thus exerting bidirectional control. Moreover, we find that OLM alpha 2 cell activation inhibits fear-related memories and that OLM alpha 2 cells respond differently to nicotine in the dorsoventral axis. These results suggest that intermediate OLM alpha 2 cells are an important component in the CA1 microcircuit regulating learning and memory processes.

Place, publisher, year, edition, pages
National Category
urn:nbn:se:uu:diva-387269 (URN)10.1016/j.neuron.2018.06.022 (DOI)000439709900017 ()29983324 (PubMedID)
Swedish Research Council, 2015-02395
Available from: 2019-06-26 Created: 2019-06-26 Last updated: 2019-06-26Bibliographically approved
Mikulovic, S., Restrepo, C. E., Siwani, S., Bauer, P., Johann, S. P., Tort, A. B. L., . . . Leão, R. N. (2018). Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor. Nature Communications, 9, 3638:1-15, Article ID 3638.
Open this publication in new window or tab >>Ventral hippocampal OLM cells control type 2 theta oscillations and response to predator odor
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2018 (English)In: Nature Communications, ISSN 2041-1723, E-ISSN 2041-1723, Vol. 9, p. 3638:1-15, article id 3638Article in journal (Refereed) Published
National Category
Neurosciences Bioinformatics (Computational Biology)
urn:nbn:se:uu:diva-364241 (URN)10.1038/s41467-018-05907-w (DOI)000444014100013 ()30194386 (PubMedID)
Available from: 2018-09-07 Created: 2018-10-29 Last updated: 2018-10-30Bibliographically approved

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