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Wenner, David
Publications (2 of 2) Show all publications
Liu, X., Pujari-Palmer, M., Wenner, D., Procter, P., Insley, G. & Engqvist, H. (2019). Adhesive Cements That Bond Soft Tissue Ex Vivo. Materials, 12(15), Article ID 2473.
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2019 (English)In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 12, no 15, article id 2473Article in journal (Refereed) Published
Abstract [en]

The aim of the present study was to evaluate the soft tissue bond strength of a newly developed, monomeric, biomimetic, tissue adhesive called phosphoserine modified cement (PMC). Two types of PMCs were evaluated using lap shear strength (LSS) testing, on porcine skin: a calcium metasilicate (CS1), and alpha tricalcium phosphate (alpha TCP) PMC. CS1 PCM bonded strongly to skin, reaching a peak LSS of 84, 132, and 154 KPa after curing for 0.5, 1.5, and 4 h, respectively. Cyanoacrylate and fibrin glues reached an LSS of 207 kPa and 33 kPa, respectively. alpha TCP PMCs reached a final LSS of approximate to 110 kPa. In soft tissues, stronger bond strengths were obtained with alpha TCP PMCs containing large amounts of amino acid (70-90 mol%), in contrast to prior studies in calcified tissues (30-50 mol%). When alpha TCP particle size was reduced by wet milling, and for CS1 PMCs, the strongest bonding was obtained with mole ratios of 30-50% phosphoserine. While PM-CPCs behave like stiff ceramics after setting, they bond to soft tissues, and warrant further investigation as tissue adhesives, particularly at the interface between hard and soft tissues.

Place, publisher, year, edition, pages
MDPI, 2019
Keywords
tissue adhesive, phosphoserine, phosphoserine modified cement, biomaterial, bioceramic, lap shear, bone cement, silicate, calcium phosphate, self-setting
National Category
Medical Materials
Identifiers
urn:nbn:se:uu:diva-393904 (URN)10.3390/ma12152473 (DOI)000482576900134 ()31382566 (PubMedID)
Funder
Swedish Research Council, RMA15-0110
Note

De två första författarna delar förstaförfattarskapet.

Available from: 2019-10-18 Created: 2019-10-18 Last updated: 2019-10-18Bibliographically approved
Pujari-Palmer, M., Guo, H., Wenner, D., Autefage, H., Spicer, C. D., Stevens, M. M., . . . Engqvist, H. (2018). A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials. Materials, 11(12), Article ID 2492.
Open this publication in new window or tab >>A Novel Class of Injectable Bioceramics that Glue Tissues and Biomaterials
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2018 (English)In: Materials, ISSN 1996-1944, E-ISSN 1996-1944, Vol. 11, no 12, article id 2492Article in journal (Refereed) Published
Abstract [en]

Calcium phosphate cements (CPCs) are clinically effective void fillers that are capable of bridging calcified tissue defects and facilitating regeneration. However, CPCs are completely synthetic/inorganic, unlike the calcium phosphate that is found in calcified tissues, and they lack an architectural organization, controlled assembly mechanisms, and have moderate biomechanical strength, which limits their clinical effectiveness. Herein, we describe a new class of bioinspired CPCs that can glue tissues together and bond tissues to metallic and polymeric biomaterials. Surprisingly, alpha tricalcium phosphate cements that are modified with simple phosphorylated amino acid monomers of phosphoserine (PM-CPCs) bond tissues up to 40-fold stronger (2.5–4 MPa) than commercial cyanoacrylates (0.1 MPa), and 100-fold stronger than surgical fibrin glue (0.04 MPa), when cured in wet-field conditions. In addition to adhesion, phosphoserine creates other novel properties in bioceramics, including a nanoscale organic/inorganic composite microstructure, and templating of nanoscale amorphous calcium phosphate nucleation. PM-CPCs are made of the biocompatible precursors calcium, phosphate, and amino acid, and these represent the first amorphous nano-ceramic composites that are stable in liquids.

Keywords
cement, tissue adhesive, phosphoserine, self-assembly, amorphous calcium phosphate (ACP), correlation nuclear magnetic resonance (NMR) spectroscopy, bioinspired, biomaterial
National Category
Composite Science and Engineering Ceramics Medical Materials Biomaterials Science
Research subject
Engineering Science with specialization in Materials Science
Identifiers
urn:nbn:se:uu:diva-369970 (URN)10.3390/ma11122492 (DOI)000456419200150 ()30544596 (PubMedID)
Funder
Swedish Foundation for Strategic Research , RMA15-0110
Available from: 2018-12-18 Created: 2018-12-18 Last updated: 2019-02-18Bibliographically approved
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