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Publications (3 of 3) Show all publications
Moulin, T. & van Egmond, L. (2019). A possible role for pollutants in mental disorders via gut microbiota [Letter to the editor]. Science of the Total Environment, 693, Article ID 133639.
Open this publication in new window or tab >>A possible role for pollutants in mental disorders via gut microbiota
2019 (English)In: Science of the Total Environment, ISSN 0048-9697, E-ISSN 1879-1026, Vol. 693, article id 133639Article in journal, Letter (Other academic) Published
Place, publisher, year, edition, pages
Elsevier, 2019
Keywords
Microplastics, Mental health, Microbiota
National Category
Environmental Sciences
Identifiers
urn:nbn:se:uu:diva-396461 (URN)10.1016/j.scitotenv.2019.133639 (DOI)000489694700008 ()31377365 (PubMedID)
Available from: 2019-11-15 Created: 2019-11-15 Last updated: 2019-11-15Bibliographically approved
Moulin, T. C., Petiz, L. L., Rayêe, D., Winne, J., Maia, R. G., Lima da Cruz, R. V., . . . Leão, R. N. (2019). Chronic in vivo optogenetic stimulation modulates neuronal excitability, spine morphology, and Hebbian plasticity in the mouse hippocampus. Hippocampus, 29(8), 755-761
Open this publication in new window or tab >>Chronic in vivo optogenetic stimulation modulates neuronal excitability, spine morphology, and Hebbian plasticity in the mouse hippocampus
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2019 (English)In: Hippocampus, ISSN 1050-9631, E-ISSN 1098-1063, Vol. 29, no 8, p. 755-761Article in journal (Refereed) Published
Abstract [en]

Prolonged increases in excitation can trigger cell‐wide homeostatic responses in neurons, altering membrane channels, promoting morphological changes, and ultimately reducing synaptic weights. However, how synaptic downscaling interacts with classical forms of Hebbian plasticity is still unclear. In this study, we investigated whether chronic optogenetic stimulation of hippocampus CA1 pyramidal neurons in freely moving mice could (a) cause morphological changes reminiscent of homeostatic scaling, (b) modulate synaptic currents that might compensate for chronic excitation, and (c) lead to alterations in Hebbian plasticity. After 24 hr of stimulation with 15‐ms blue light pulses every 90 s, dendritic spine density and area were reduced in the CA1 region of mice expressing channelrhodopsin‐2 (ChR2) when compared to controls. This protocol also reduced the amplitude of mEPSCs for both the AMPA and NMDA components in ex vivo slices obtained from ChR2‐expressing mice immediately after the end of stimulation. Finally, chronic stimulation impaired the induction of LTP and facilitated that of LTD in these slices. Our results indicate that neuronal responses to prolonged network excitation can modulate subsequent Hebbian plasticity in the hippocampus.

Keywords
long-term depression, long-term potentiation, optogenetics, synaptic plasticity, synaptic scaling
National Category
Biophysics Neurosciences
Identifiers
urn:nbn:se:uu:diva-380035 (URN)10.1002/hipo.23080 (DOI)000475815400008 ()30767318 (PubMedID)
Available from: 2019-03-22 Created: 2019-03-22 Last updated: 2019-08-16Bibliographically approved
Moulin, T., Rayee, D., Maia, R., Freitas, J., Lima, R., Petiz, L., . . . Amaral, O. (2018). Chronic in vivo optogenetic stimulation modulates Hebbian plasticity and spine density in the mouse hippocampus. biorxiv
Open this publication in new window or tab >>Chronic in vivo optogenetic stimulation modulates Hebbian plasticity and spine density in the mouse hippocampus
Show others...
2018 (English)In: biorxivArticle in journal (Other academic) Published
Abstract [en]

Continuous excitation can trigger cell-wide homeostatic responses in neurons, altering membrane channels, promoting morphological changes and ultimately reducing synaptic weights. However, how synaptic downscaling interacts with classical forms of Hebbian plasticity is still unclear. In this study, we investigated whether chronic optogenetic stimulation of hippocampus CA1 pyramidal neurons in freely-moving mice could (a) cause morphological changes reminiscent of homeostatic scaling, and (b) lead to alterations in Hebbian plasticity. After 24 h of stimulation with 15-ms blue light pulses every 90 s, dendritic spine density was reduced in the CA1 region of mice expressing channelrhodopsin-2 (ChR2) when compared to controls. This protocol also impaired the induction of LTP and facilitated that of LTD in ex vivo slices obtained from ChR2-expressing mice immediately after the end of stimulation. Our results indicate that neuronal responses to prolonged network excitation can modulate subsequent Hebbian plasticity in the hippocampus.

Keywords
optogenetic, LTP
National Category
Neurosciences
Identifiers
urn:nbn:se:uu:diva-364406 (URN)10.1101/320507 (DOI)
Available from: 2018-10-25 Created: 2018-10-25 Last updated: 2019-01-23Bibliographically approved
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ORCID iD: ORCID iD iconorcid.org/0000-0001-7811-5383

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