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Wågsäter, Dick
Publications (2 of 2) Show all publications
Alehagen, U. & Wågsäter, D. (2019). Gender difference and genetic variance in lipoprotein receptor-related protein 1 is associated with mortality. BIOMEDICAL REPORTS, 11(1), 3-10
Open this publication in new window or tab >>Gender difference and genetic variance in lipoprotein receptor-related protein 1 is associated with mortality
2019 (English)In: BIOMEDICAL REPORTS, ISSN 2049-9434, Vol. 11, no 1, p. 3-10Article in journal (Refereed) Published
Abstract [en]

Cardiovascular diseases are an important health resource problem and studies have shown a genetic association between single nucleotide polymorphisms (SNPs) and cardiovascular diseases. According to the literature, lipoprotein receptor-related protein 1 (LRP1) is associated with coronary artery disease. The aim of the present study was to evaluate a possible association between different genotypes of LRP1 and all-cause and cardiovascular mortality from a gender perspective. In the present study, 489 elderly community-living people were invited to participate. Clinical examination, echocardiography and blood sampling including SNP analyses of LRP1 (rs1466535) were performed, including the T/T, C/T and C/C genotypes, and the participants were followed for 6.7 years. During the follow-up period, 116 (24%) all-cause and 75 (15%) cardiovascular deaths were registered. In the female population, the LRP1 of the T/T or C/T genotype exhibited a 5.6-fold increased risk of cardiovascular mortality and a 2.8-fold increased risk of all-cause mortality compared with the C/C genotype. No such genotype differences could be seen in the male population. Gender differences could be seen regarding the risk of mortality in the different genotypes. Females with the LRP1 T/T or C/T genotypes exhibited a significantly increased risk of both all-cause and cardiovascular mortality compared with the C/C genotypes. Therefore, more individualized cardiovascular prevention and treatment should be prioritized. However, since this was a small study, the observations should only be regarded as hypothesis-generating.

Keywords
low-density lipoprotein receptor-related protein 1, genotypes, elderly, genders, mortality
National Category
Cardiac and Cardiovascular Systems
Identifiers
urn:nbn:se:uu:diva-390973 (URN)10.3892/br.2019.1217 (DOI)000474635900003 ()31258899 (PubMedID)
Funder
Swedish Heart Lung Foundation
Available from: 2019-08-16 Created: 2019-08-16 Last updated: 2019-08-16Bibliographically approved
Dimberg, J., Shamoun, L., Landerholm, K., Andersson, R. E., Kolodziej, B. & Wågsäter, D. (2019). Genetic Variants of the IL2 Gene Related to Risk and Survival in Patients With Colorectal Cancer. Anticancer Research, 39(9), 4933-4940
Open this publication in new window or tab >>Genetic Variants of the IL2 Gene Related to Risk and Survival in Patients With Colorectal Cancer
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2019 (English)In: Anticancer Research, ISSN 0250-7005, E-ISSN 1791-7530, Vol. 39, no 9, p. 4933-4940Article in journal (Refereed) Published
Abstract [en]

Background: Interleukin 2 (IL2) is a significant factor activating T-cell-mediated immune response by stimulation of natural killer cells, T-cells and in development of regulatory T (Treg) cells. Recent studies have that IL2 participates in cancer development by modifying the local immune response. Based on the suggested role of the single nucleotide polymorphisms (SNPs) rs2069762, rs6822844 and rs11938795 of IL2 in the pathogenesis of certain diseases, the relationship of these SNPs with clinicopathological variables and their possible implication for prognosis and disease outcome were evaluated in a cohort of Swedish patients with colorectal cancer (CRC). Materials and Methods: TaqMan SNP genotype assays based on polymerase chain reaction were used for analysis of the IL2 SNPs in 467 patients with CRC and 467 healthy controls. Expression analysis of IL2 in plasma and CRC tissue was also performed. Results: The allelic variants T in rs11938795 and G in rs6822844 were significantly associated with a higher risk of CRC. Kaplan-Meier analysis showed that cancer-specific survival was worse for individuals with C allele for rs2069762 with stage II CRC and with T allele for rs6822844 with stage III CRC. Conclusion: SNPs rs2069762, rs6822844 and rs11938795 of the IL2 gene may be helpful as prognostic biomarkers in the follow-up and management of the patients.

Keywords
SNP, colorectal cancer, immunoregulation, prognosis
National Category
Cancer and Oncology
Identifiers
urn:nbn:se:uu:diva-395623 (URN)10.21873/anticanres.13681 (DOI)000486457600044 ()31519598 (PubMedID)
Available from: 2019-10-22 Created: 2019-10-22 Last updated: 2019-10-22Bibliographically approved
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