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Hellkvist, A., Wikström, J., Mulic-Lutvica, A., Ericson, K., Eriksson-Falkerby, C., Lindgren, P., . . . Axelsson, O. (2019). Postmortem magnetic resonance imaging vs autopsy of second trimester fetuses terminated due to anomalies. Acta Obstetricia et Gynecologica Scandinavica, 98(7), 865-876
Open this publication in new window or tab >>Postmortem magnetic resonance imaging vs autopsy of second trimester fetuses terminated due to anomalies
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2019 (English)In: Acta Obstetricia et Gynecologica Scandinavica, ISSN 0001-6349, E-ISSN 1600-0412, Vol. 98, no 7, p. 865-876Article in journal (Refereed) Published
Abstract [en]

INTRODUCTION: Our aim was to investigate the accuracy of postmortem fetal magnetic resonance imaging (MRI) compared to fetal autopsy in second trimester pregnancies terminated due to fetal anomalies. A secondary aim was to compare the MRI evaluations of two senior radiologists.

MATERIAL AND METHODS: This was a prospective study including 34 fetuses from pregnancies terminated in the second trimester due to fetal anomalies. All women accepted a postmortem MRI and an autopsy of the fetus. Two senior radiologists performed independent evaluations of the MRI images. A senior pathologist performed the fetal autopsies. The degree of concordance between the MRI evaluations and the autopsy reports was estimated as well as the consensus between the radiologists.

RESULTS: Thirty-four fetuses were evaluated. Sixteen cases were associated with the central nervous system (CNS), five musculoskeletal, one cardiovascular, one urinary tract, and 11 cases had miscellaneous anomalies such as chromosomal aberrations, infections, and syndromes. In the 16 cases related to the CNS, both radiologists reported all or some, including the most clinically significant anomalies in 15 (94%; CI 70-100%) cases. In the 18 non-CNS cases, both radiologists reported all or some, including the most clinically significant anomalies in six (33%; CI 5-85%) cases. In 21 cases (62%; CI 44-78%) cases, both radiologists held opinions that were consistent with the autopsy reports. The degree of agreement between the radiologists was high, with a Cohen's Kappa of 0.87.

CONCLUSIONS: Postmortem fetal MRI can replace autopsy for second trimester fetuses with CNS anomalies. For non-CNS anomalies, the concordance is lower but postmortem MRI can still be of value when autopsy is not an option.

Keywords
Fetal anomalies, Fetal diagnosis, Post-mortem fetal MRI, Prenatal diagnosis, Prospective study, Second trimester
National Category
Radiology, Nuclear Medicine and Medical Imaging
Research subject
Pathology
Identifiers
urn:nbn:se:uu:diva-375605 (URN)10.1111/aogs.13548 (DOI)000472678200006 ()30694559 (PubMedID)
Funder
Swedish Society of Medicine
Available from: 2019-01-31 Created: 2019-01-31 Last updated: 2020-01-03Bibliographically approved
Organisations
Identifiers
ORCID iD: ORCID iD iconorcid.org/0000-0001-6856-3465

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