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Minimally invasive spine treatments have been sought after for elderly patients with comorbidities suffering fromadvanced degenerative disc disease. Percutaneous cement discoplasty (PCD) is one such technique where cementis injected into a degenerated disc with a vacuum phenomenon to relieve patients from pain. Adjacent vertebralfractures (AVFs) are however an inherent risk, particularly for osteoporotic patients, due to the high stiffness ofthe used cements. While low-modulus cements have been developed for vertebroplasty through the addition oflinoleic acid, there are no such variations with a high-viscosity base cement, which is likely needed for thediscoplasty application.Therefore, a low-modulus polymethyl methacrylate was developed by the addition of 12%vol. linoleic acid toa high-viscosity bone cement (hv-LA-PMMA). Initial experimental validation of the cement was performed bymechanical testing under compression over a period of 24 weeks, after storage in 37 ◦C phosphate buffer saline(PBS) solution. Furthermore, cement extracts were used to evaluate residual monomer release and the cyto-toxicity of hv-LA-PMMA using fibroblastic cells.Relative to the base commercial cement, a significant reduction of Young’s modulus and compressive strengthof 36% and 42% was observed, respectively. Compression-tension fatigue tests at 5 MPa gave an average fatiguelimit of 31,078 cycles. This was higher than another low-modulus cement and comparable to the fatigueproperties of the disc annulus tissue. Monomer release tests showed that hv-LA-PMMA had a significantly higherrelease between 24 h and 7 days compared to the original bone cement, similarly to other low-modulus cements.Also, the control cement showed cytocompatibility at all time points of extract collection for 20-fold dilution,while hv-LA-PMMA only showed the same for extract collections at day 7. However, the 20-fold dilution wasneeded for both the control and the hv-LA-PMMA extracts to demonstrate more than 70% fibroblast viability atday 7.In conclusion, the mechanical testing showed promise in the use of linoleic acid in combination with a high-viscosity PMMA cement to achieve properties adequate to the application. Further testing and in vivo studies arehowever required to fully evaluate the mechanical performance and biocompatibility of hv-LA-PMMA forpossible future clinical application.