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Title [sv]
PERSISTENTA ORGANISKA MILJÄGIFTER OCH KARDIOVASKULÄR SJUKDOM FR ÅN ETT KÄNSPERSPEKTIV
Title [en]
PERSISTANT ORGANIC POLLUTANTS (POPs) AND CARDIOVASCULAR DISEASES FROM A GENDER PERSPECTIVE
Abstract [sv]
A recent publication showed an association between levels of persistent organic pollutants (POPs) and self-reported cardiovascular disease (CVD) in women. We have investigated a population-based sample of 1016 individuals being 70 years old (50 % female). In this Prospective Investigation of the Vasculature in Uppsala Seniors (PIVUS) study we have made a much more thorough characterisation of cardiovascular risk factors, vascular function, myocardial function and morphology and atherosclerosis. This cohort is now reinvestigated in a similar way at age 75. Serum has been frozen for analysis for selected circulating POPs (Stockholm convention). Data analysis will take place in three steps in a gender specific manner: 1) A cross-sectional analysis of the relationships between the POPs and cardiovascular risk factors, vascular function, myocardial function and atherosclerosis at age 70. 2) After collection of the 75 year data in 2009, an analysis of the relationships between the POPs and data on changes in risk factors, vascular function, myocardial function and atherosclerosis between age 70 and 75 will take place. 3) Future CVD events will be recorded and relationships between POP levels and future CVD will be analysed. Measurements of POPs in this cohort of extremely well characterized subjects is an unique possibility to disclose any relationships between POPs and future CVD, and could also disclose underlying mechanisms, all with a gender perspective.
Principal InvestigatorLind, Lars
Coordinating organisation
Uppsala University
Funder
Period
2009-01-01 - 2011-12-31
Identifiers
DiVA, id: project:3269Project, id: 2008-02214_VR

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