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Project type/Form of grant
Project grant
Title [sv]
Experimenttid vid SLAC, Stanford university
Title [en]
Nanocrystal imaging using intense and ultrashort X-ray pulses
Abstract [sv]
Structural studies of biological macromolecules are severely limited by radiation damage. Traditional crystallography curbs the effects of damage by spreading damage over many copies of the molecule of interest in the crystal. The recently built X-ray laser LINAC Coherent Light Source (LCLS) in the USA, offers an additional opportunity for limiting damage by out-running damage processes with ultrashort and very intense X-ray pulses. Such pulses may allow the imaging of single molecules, clusters or nanoparticles, but coherent flash imaging will also open up new avenues for structural studies on nano- and micro-crystalline substances. This proposal deals with the participation at the experiments at LCLS, where protein nanocrystals (Lysozyme and Photosystem I) will be irradiated by X-ray pulses. This is a continuation of my theoretical work on radiation damage, addressing the potentials and limitations of nanocrystallography with extremely intense coherent X-ray pulses. I am part of an international collaboration which has been granted exclusive access at LCLS for performing coherent imaging studies on nanocrystals. These experiments hold the promise of high scientific return and can open a new avenue for high throughput protein nanocrystallography.
Principal InvestigatorTimneanu, Nicusor
Coordinating organisation
Uppsala University
2011-01-01 - 2011-12-31
DiVA, id: project:4350Project, id: 2010-07395_VR

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