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Title [sv]
Metaboliska sårbarheter för personcentrerade terapeutiska approacher inom akut myeloisk leukemi
Title [en]
Metabolic vulnerabilities for personalized therapeutic approaches in acute myeloid leukemia
Abstract [en]
Current personalized medicine approaches in acute myeloid leukemia (AML) are restricted to the identification of actionable genomic lesions, with great differences in clinical outcome and response. A clear understanding of the biological consequences of the genomic alterations is crucial to tailor therapeutic strategies. However, subgroup- and patient-specific metabolic dependencies and preferences are largely unexplored. MEET-AML aims to identify metabolic vulnerabilities in AML and develop a model to integrate multilayer omics and social data in order to define phenotypic profiles and personalized therapeutic approaches, while understanding patients’ perspective. We will characterize the genomic and transcriptomic landscape of AML (WP2) and map their metabolic and proteomic networks (WP3). Patients’ preferences will assessed with input from the direct involvement of patient representatives (WP6). Omics data will be integrated through Systems Biology algorithms to create a new model for phenotypic profiles, prediction of synthetic lethality based on human genome-scale metabolic networks and prioritization of the identified targets (WP4). In vitro experiments and ex vivo screening of metabolism-targeting agents will functionally validate metabolic vulnerabilities and their associated response biomarkers. We will also develop a module for training clinicians about innovative therapeutic options (WP5) and patients’ perspectives (WP6), to guide future clinical practice.
Principal InvestigatorKihlbom, Ulrik
Coordinating organisation
Uppsala University
Funder
Period
2020-01-01 - 2022-12-31
National Category
Cancer and Oncology
Identifiers
DiVA, id: project:6403Project, id: 2019-00903_VR

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