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Simplifying Reproductive Health in Low-Resource Settings: Access to medical abortion and contraceptive choice, the importance of gendered structures in Rajasthan
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Internationell mödra- och barnhälsovård (IMCH).ORCID-id: 0000-0002-5841-5984
2015 (Engelska)Doktorsavhandling, sammanläggning (Övrigt vetenskapligt)
Abstract [en]

India introduced family planning in the ‘50s, legalized abortion in the ‘70s, and accomplished a remarkable drop in maternal mortality and fertility since 1990. Nevertheless, abortions account for a large proportion of maternal deaths, and sterilization is the most frequently used contraception. This thesis aims to identify the means to simplify and increase access to reproductive health in low-resource settings, focusing on abortion and contraception in Rajasthan.

A randomized controlled trial compared simplified follow-up, where women assess their abortion outcome at home after early medical abortion, with in-clinic follow-up. Additionally, contraceptive use was compared between study groups post-abortion. In order to explore young women’s opportunities to access reproductive health services in the area, we conducted in-depth interviews with recently-married women.

Women in the home-assessment group preferred home-assessment in the future to a greater extent than the women in the clinic follow-up group, who preferred in-clinic follow-up. Complete abortions were reported in 95% of women in the ‘home-assessment group’ and 93% in the ‘in-clinic group’, suggesting that efficacy of simplified follow-up is non-inferior to in-clinic follow-up. A majority (81%) of women carried out the pregnancy test and found it easy to use. Women (96%) were satisfied with their abortion. There were no differences in contraceptive use between study groups at three months; however, women in the ‘in-clinic group’ were most likely to initiate contraception at two weeks. A majority of women preferred the three-month injection, while only 4% preferred sterilization. The recently-married women considered reversible contraception to be unfeasible due to misconceptions and taboos, yet women wanted effective contraception because their current use of traditional methods resulted in unintended pregnancies. Abortions were common, and were procured from private or informal providers.

Allowing women to take an active role in reproductive health services can enable simplification of, and access to, reproductive services in low-resource settings as well as in other settings. Simplifying medical abortion, providing contraception ‘intra-abortion’, and offering a context-appropriate and effective means of contraception, creates a great potential to increase access to reproductive health services and can result in a more equal society where women, and men, can attain their sexual and reproductive rights.

Ort, förlag, år, upplaga, sidor
Uppsala: Acta Universitatis Upsaliensis, 2015. , 144 s.
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 1163
Nyckelord [en]
Medical abortion, Contraception, Access, Simplified, Gender, Sexual and reproductive health and rights, India
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Hälso- och sjukvårdsorganisation, hälsopolitik och hälsoekonomi Reproduktionsmedicin och gynekologi
Forskningsämne
Internationell hälsa
Identifikatorer
URN: urn:nbn:se:uu:diva-267167ISBN: 978-91-554-9414-8 (tryckt)OAI: oai:DiVA.org:uu-267167DiVA: diva2:872467
Disputation
2016-01-11, Gustavianum, Akademigatan 3, Uppsala, 13:00 (Engelska)
Opponent
Handledare
Tillgänglig från: 2015-12-14 Skapad: 2015-11-18 Senast uppdaterad: 2016-01-13
Delarbeten
1. Acceptability of Home-Assessment PostMedical Abortion and Medical Abortion in aLow-Resource Setting in Rajasthan, India: Secondary Outcome Analysis of a Non-Inferiority Randomized Controlled Trial
Öppna denna publikation i ny flik eller fönster >>Acceptability of Home-Assessment PostMedical Abortion and Medical Abortion in aLow-Resource Setting in Rajasthan, India: Secondary Outcome Analysis of a Non-Inferiority Randomized Controlled Trial
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2015 (Engelska)Ingår i: PLoS ONE, ISSN 1932-6203, E-ISSN 1932-6203, Vol. 10, nr 9, e0133354Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background

Studies evaluating acceptability of simplified follow-up after medical abortion have focused on high-resource or urban settings where telephones, road connections, and modes of transport are available and where women have formal education.

Objective

To investigate women’s acceptability of home-assessment of abortion and whether acceptability of medical abortion differs by in-clinic or home-assessment of abortion outcome in a low-resource setting in India.

Design

Secondary outcome of a randomised, controlled, non-inferiority trial.

Setting

Outpatient primary health care clinics in rural and urban Rajasthan, India.

Population

Women were eligible if they sought abortion with a gestation up to 9 weeks, lived within defined study area and agreed to follow-up. Women were ineligible if they had known contraindications to medical abortion, haemoglobin < 85mg/l and were below 18 years.

Methods

Abortion outcome assessment through routine clinic follow-up by a doctor was compared with home-assessment using a low-sensitivity pregnancy test and a pictorial instruction sheet. A computerized random number generator generated the randomisation sequence (1:1) in blocks of six. Research assistants randomly allocated eligible women who opted for medical abortion (mifepristone and misoprostol), using opaque sealed envelopes. Blinding during outcome assessment was not possible.

Main Outcome Measures

Women’s acceptability of home-assessment was measured as future preference of follow-up. Overall satisfaction, expectations, and comparison with previous abortion experiences were compared between study groups.

Results

731 women were randomized to the clinic follow-up group (n = 353) or home-assessment group (n = 378). 623 (85%) women were successfully followed up, of those 597 (96%) were satisfied and 592 (95%) found the abortion better or as expected, with no difference between study groups. The majority, 355 (57%) women, preferred home-assessment in the event of a future abortion. Significantly more women, 284 (82%), in the home-assessment group preferred home-assessment in the future, as compared with 188 (70%) of women in the clinic follow-up group, who preferred clinic follow-up in the future (p < 0.001).

Conclusion

Home-assessment is highly acceptable among women in low-resource, and rural, settings. The choice to follow-up an early medical abortion according to women’s preference should be offered to foster women’s reproductive autonomy.

Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi Reproduktionsmedicin och gynekologi
Identifikatorer
urn:nbn:se:uu:diva-262580 (URN)10.1371/journal.pone.0133354 (DOI)000360437700006 ()
Forskningsfinansiär
Vetenskapsrådet, 2011-3525Sida - Styrelsen för internationellt utvecklingssamarbete
Tillgänglig från: 2015-09-16 Skapad: 2015-09-16 Senast uppdaterad: 2016-01-13
2. Self-assessment of the outcome of early medical abortion versus clinic follow-up in India: a randomised, controlled, non-inferiority trial
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2015 (Engelska)Ingår i: LANCET GLOBAL HEALTH, ISSN 2214-109X, Vol. 3, nr 9, E537-E545 s.Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

Background The need for multiple clinical visits remains a barrier to women accessing safe legal medical abortion services. Alternatives to routine clinic follow-up visits have not been assessed in rural low-resource settings. We compared the effectiveness of standard clinic follow-up versus home assessment of outcome of medical abortion in a low-resource setting. Methods This randomised, controlled, non-inferiority trial was done in six health centres (three rural, three urban) in Rajasthan, India. Women seeking early medical abortion up to 9 weeks of gestation were randomly assigned (1:1) to either routine clinic follow-up or self-assessment at home. Randomisation was done with a computer-generated randomisation sequence, with a block size of six. The study was not blinded. Women in the home-assessment group were advised to use a pictorial instruction sheet and take a low-sensitivity urine pregnancy test at home, 10-14 days after intake of mifepristone, and were contacted by a home visit or telephone call to record the outcome of the abortion. The primary (non-inferiority) outcome was complete abortion without continuing pregnancy or need for surgical evacuation or additional mifepristone and misoprostol. The non-inferiority margin for the risk difference was 5%. All participants with a reported primary outcome and who followed the clinical protocol were included in the analysis. This study is registered with ClinicalTrials.gov, number NCT01827995. Findings Between April 23, 2013, and May 15, 2014, 731 women were recruited and assigned to clinic follow-up (n=366) or home assessment (n=365), of whom 700 were analysed for the main outcomes (n=336 and n=364, respectively). Complete abortion without continuing pregnancy, surgical intervention, or additional mifepristone and misoprostol was reported in 313 (93%) of 336 women in the clinic follow-up group and 347 (95%) of 364 women in the home-assessment group (difference -2.2%, 95% CI -5.9 to 1.6). One case of haemorrhage occurred in each group (rate of adverse events 0.3% in each group); no other adverse events were noted. Interpretation Home assessment of medical abortion outcome with a low-sensitivity urine pregnancy test is non-inferior to clinic follow-up, and could be introduced instead of a clinic follow-up visit in a low-resource setting.

Nationell ämneskategori
Miljömedicin och yrkesmedicin Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:uu:diva-263448 (URN)000360559500019 ()26275330 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 2011-3525
Tillgänglig från: 2015-10-06 Skapad: 2015-09-30 Senast uppdaterad: 2016-01-13Bibliografiskt granskad
3. Does mode of follow-up influence contraceptive use post-medical abortion in a low-resource setting? Secondary outcome analysis of a non-inferiority randomized controlled trial
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(Engelska)Artikel i tidskrift (Refereegranskat) Submitted
Nationell ämneskategori
Folkhälsovetenskap, global hälsa, socialmedicin och epidemiologi
Identifikatorer
urn:nbn:se:uu:diva-267166 (URN)
Tillgänglig från: 2015-11-18 Skapad: 2015-11-18 Senast uppdaterad: 2016-01-13
4. Negotiating Collective and Individual Agency: A Qualitative Study of Young Women's Reproductive Health in Rural India.
Öppna denna publikation i ny flik eller fönster >>Negotiating Collective and Individual Agency: A Qualitative Study of Young Women's Reproductive Health in Rural India.
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2017 (Engelska)Ingår i: Qualitative Health Research, ISSN 1049-7323, E-ISSN 1552-7557, Vol. 27, nr 3, 311-324 s.Artikel i tidskrift (Refereegranskat) Published
Abstract [en]

The societal changes in India and the available variety of reproductive health services call for evidence to inform health systems how to satisfy young women's reproductive health needs. Inspired by Foucault's power idiom and Bandura's agency framework, we explore young women's opportunities to practice reproductive agency in the context of collective social expectations. We carried out in-depth interviews with 19 young women in rural Rajasthan. Our findings highlight how changes in notions of agency across generations enable young women's reproductive intentions and desires, and call for effective means of reproductive control. However, the taboo around sex without the intention to reproduce made contraceptive use unfeasible. Instead, abortions were the preferred method for reproductive control. In conclusion, safe abortion is key, along with the need to address the taboo around sex to enable use of "modern" contraception. This approach could prevent unintended pregnancies and expand young women's agency.

Nationell ämneskategori
Medicin och hälsovetenskap
Identifikatorer
urn:nbn:se:uu:diva-266827 (URN)10.1177/1049732315613038 (DOI)000394093500002 ()26531879 (PubMedID)
Forskningsfinansiär
Vetenskapsrådet, 2011-3525Wellcome trust, 096527
Tillgänglig från: 2015-11-11 Skapad: 2015-11-11 Senast uppdaterad: 2017-03-27Bibliografiskt granskad

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