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The MINDVIEW project: First results
Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain.
Univ Politecn Valencia, CSIC, Inst Instrumentat Mol Imaging M I3, Valencia, Spain.
Sapienza Univ Rome, Dept Mol Med, Rome, Italy.
Sapienza Univ Rome, Dept Mol Med, Rome, Italy.
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2018 (English)In: European psychiatry, ISSN 0924-9338, E-ISSN 1778-3585, Vol. 50, p. 21-27Article in journal (Refereed) Published
Abstract [en]

We present the first results of the MINDVIEW project. An innovative imaging system for the human brain examination, allowing simultaneous acquisition of PET/MRI images, has been designed and constructed. It consists of a high sensitivity and high resolution PET scanner integrated in a novel, head-dedicated, radio frequency coil for a 3T MRI scanner. Preliminary measurements from the PET scanner show sensitivity 3 times higher than state-of-the-art PET systems that will allow safe repeated studies on the same patient. The achieved spatial resolution, close to 1 mm, will enable differentiation of relevant brain structures for schizophrenia. A cost-effective and simple method of radiopharmaceutical production from 11C-carbon monoxide and a mini-clean room has been demonstrated. It has been shown that 11C-raclopride has higher binding potential in a new VAAT null mutant mouse model of schizophrenia compared to wild type control animals. A significant reduction in TSPO binding has been found in gray matter in a small sample of drug-naïve, first episode psychosis patients, suggesting a reduced number or an altered function of immune cells in brain at early stage schizophrenia.

Place, publisher, year, edition, pages
2018. Vol. 50, p. 21-27
Keywords [en]
Schizophrenia, Positron Emission Tomography, Silicon photomultipliers and magnetic resonance
National Category
Radiology, Nuclear Medicine and Medical Imaging
Identifiers
URN: urn:nbn:se:uu:diva-353215DOI: 10.1016/j.eurpsy.2018.01.002ISI: 000430263900004PubMedID: 29398564OAI: oai:DiVA.org:uu-353215DiVA, id: diva2:1217336
Available from: 2018-06-13 Created: 2018-06-13 Last updated: 2018-06-13Bibliographically approved

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