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Design and methodology of the screening for CKD among older patients across Europe (SCOPE) study: a multicenter cohort observational study
INRCA Ancona, Ancona, Italy;INRCA, Fermo, Italy;INRCA, Cosenza, Italy.
Erasmus Univ, Geriatr Med Sect, Dept Internal Med, Med Ctr Rotterdam, Rotterdam, Netherlands.
Med Univ Graz, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria.
Med Univ Graz, Dept Internal Med, Auenbruggerpl 15, A-8036 Graz, Austria.
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2018 (English)In: BMC Nephrology, ISSN 1471-2369, E-ISSN 1471-2369, Vol. 19, article id 260Article in journal (Refereed) Published
Abstract [en]

Background: Decline of renal function is common in older persons and the prevalence of chronic kidney disease (CKD) is rising with ageing. CKD affects different outcomes relevant to older persons, additionally to morbidity and mortality which makes CKD a relevant health burden in this population. Still, accurate laboratory measurement of kidney function is under debate, since current creatinine-based equations have a certain degree of inaccuracy when used in the older population. The aims of the study are as follows: to assess kidney function in a cohort of 75+ older persons using existing methodologies for CKD screening; to investigate existing and innovative biomarkers of CKD in this cohort, and to align laboratory and biomarker results with medical and functional data obtained from this cohort. The study was registered at ClinicalTrials.gov, identifier NCT02691546, February 25th 2016. Methods/design: An observational, multinational, multicenter, prospective cohort study in community dwelling persons aged 75 years and over, visiting the outpatient clinics of participating institutions. The study will enroll 2450 participants and is carried out in Austria, Germany, Israel, Italy, the Netherlands, Poland and Spain. Participants will undergo clinical and laboratory evaluations at baseline and after 12 and 24 months-follow-up. Clinical evaluation also includes a comprehensive geriatric assessment (CGA). Local laboratory will be used for 'basic' parameters (including serum creatinine and albumin-to-creatinine ratio), whereas biomarker assessment will be conducted centrally. An intermediate telephone follow-up will be carried out at 6 and 18 months. Discussion: Combining the use of CGA and the investigation of novel and existing independent biomarkers within the SCOPE study will help to provide evidence in the development of European guidelines and recommendations in the screening and management of CKD in older people.

Place, publisher, year, edition, pages
BMC , 2018. Vol. 19, article id 260
Keywords [en]
Chronic kidney disease, Older people, Disability, Frailty, Ageing
National Category
Urology and Nephrology
Identifiers
URN: urn:nbn:se:uu:diva-369107DOI: 10.1186/s12882-018-1030-2ISI: 000447187600005PubMedID: 30309342OAI: oai:DiVA.org:uu-369107DiVA, id: diva2:1271453
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EU, Horizon 2020, 634869Available from: 2018-12-17 Created: 2018-12-17 Last updated: 2018-12-17Bibliographically approved

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Ärnlöv, JohanCarlsson, Axel C

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