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Evolution of New Functions De Novo and from Preexisting Genes
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.
Uppsala University, Disciplinary Domain of Medicine and Pharmacy, Faculty of Medicine, Department of Medical Biochemistry and Microbiology.ORCID iD: 0000-0002-6831-3105
2015 (English)In: Cold Spring Harbor Perspectives in Biology, E-ISSN 1943-0264, Vol. 7, no 6, article id a017996Article, review/survey (Refereed) Published
Abstract [en]

How the enormous structural and functional diversity of new genes and proteins was generated (estimated to be 10^10-€“10^12 different proteins in all organisms on earth [Choi I-G, Kim S-H. 2006. Evolution of protein structural classes and protein sequence families. Proc Natl Acad Sci 103: 14056–14061] is a central biological question that has a long and rich history. Extensive work during the last 80 years have shown that new genes that play important roles in lineage-specific phenotypes and adaptation can originate through a multitude of different mechanisms, including duplication, lateral gene transfer, gene fusion/fission, and de novo origination. In this review, we focus on two main processes as generators of new functions: evolution of new genes by duplication and divergence of pre-existing genes and de novo gene origination in which a whole protein-coding gene evolves from a noncoding sequence.

Place, publisher, year, edition, pages
2015. Vol. 7, no 6, article id a017996
National Category
Evolutionary Biology
Research subject
Biology with specialization in Molecular Evolution
Identifiers
URN: urn:nbn:se:uu:diva-253740DOI: 10.1101/cshperspect.a017996ISI: 000358241300006OAI: oai:DiVA.org:uu-253740DiVA, id: diva2:815981
Funder
Swedish Research CouncilAvailable from: 2015-06-02 Created: 2015-06-02 Last updated: 2023-11-06Bibliographically approved

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Publisher's full texthttp://cshperspectives.cshlp.org/content/7/6/a017996.abstract

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Andersson, Dan I.Jerlström-Hultqvist, JonNäsvall, Joakim

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