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Changes in brain architecture are consistent with altered fear processing in domestic rabbits
KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Huddinge, Sweden.
Univ Porto, Ctr Invest Biodiversidade & Recursos Genet CIBIO, InBIO, Vairao, Portugal; Univ Porto, Dept Biol, Fac Ciencias, Porto, Portugal.
KTH Royal Inst Technol, Dept Biomed Engn & Hlth Syst, Huddinge, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinsk biokemi och mikrobiologi. Uppsala universitet, Science for Life Laboratory, SciLifeLab.
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2018 (engelsk)Inngår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 115, nr 28, s. 7380-7385Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

The most characteristic feature of domestic animals is their change in behavior associated with selection for tameness. Here we show, using high-resolution brain magnetic resonance imaging in wild and domestic rabbits, that domestication reduced amygdala volume and enlarged medial prefrontal cortex volume, supporting that areas driving fear have lost volume while areas modulating negative affect have gained volume during domestication. In contrast to the localized gray matter alterations, white matter anisotropy was reduced in the corona radiata, corpus callosum, and the subcortical white matter. This suggests a compromised white matter structural integrity in projection and association fibers affecting both afferent and efferent neural flow, consistent with reduced neural processing. We propose that compared with their wild ancestors, domestic rabbits are less fearful and have an attenuated flight response because of these changes in brain architecture.

sted, utgiver, år, opplag, sider
2018. Vol. 115, nr 28, s. 7380-7385
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Identifikatorer
URN: urn:nbn:se:uu:diva-355452DOI: 10.1073/pnas.1801024115ISI: 000438050900076PubMedID: 29941556OAI: oai:DiVA.org:uu-355452DiVA, id: diva2:1229070
Forskningsfinansiär
Knut and Alice Wallenberg FoundationSwedish Research CouncilThe Swedish Brain FoundationEuropean Social Fund (ESF)Tilgjengelig fra: 2018-06-29 Laget: 2018-06-29 Sist oppdatert: 2018-09-25bibliografisk kontrollert

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