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Stathmin as a Marker for Malignancy in Pheochromocytomas
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk farmakologi. (Cancer Pharmacology and Informatics/Rolf Larsson)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.
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2010 (engelsk)Inngår i: Experimental and clinical endocrinology & diabetes, ISSN 0947-7349, E-ISSN 1439-3646, Vol. 118, nr 1, s. 27-30Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Pheochromocytomas of the adrenal medulla may be life-threatening catecholamine-producing tumors which are malignant in about 10% of cases. Differential diagnosis between malignant and benign tumors is dependent on the development of metastasis or extensive local invasion. A number of genetic aberrations have been described in pheochromocytomas, but no marker associated to malignancy has been reported. We applied an expression microarray containing 7770 cDNA clones and analysed the expression profiles in eleven tumors compared to normal adrenal medulla. Stathmin (STMN1, Op18) was most conspiciously overexpressed among the differentially expressed genes. RT-PCR analysis further confirmed mRNA overexpression, 6 to 8-fold for benign and malignant tumors, and 16-fold for metastases. Stathmin protein overexpression was observed by immunohistochemistry, and distinct differential protein expression between benign and malignant/metastasis specimens was confirmed by Western blot analysis. The results introduce stathmin as a possible diagnostic marker for malignant pheochromocytomas, and further evaluations are warranted.

sted, utgiver, år, opplag, sider
2010. Vol. 118, nr 1, s. 27-30
Emneord [en]
Benign, Malignant, Microarray, Op18, Pheochromocytoma, Stathmin, STMN1
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Identifikatorer
URN: urn:nbn:se:uu:diva-113090DOI: 10.1055/s-0029-1202789ISI: 000274245700006PubMedID: 19449284OAI: oai:DiVA.org:uu-113090DiVA, id: diva2:289652
Tilgjengelig fra: 2010-01-25 Laget: 2010-01-25 Sist oppdatert: 2017-12-12

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