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Cognitive Function Prior to Stroke is a Risk Factor for Post-Stroke Mortality but Not Dependency
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för folkhälso- och vårdvetenskap, Geriatrik.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper.ORCID-id: 0000-0003-2247-8454
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kirurgiska vetenskaper. Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Uppsala kliniska forskningscentrum (UCR).ORCID-id: 0000-0002-4421-6466
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(engelsk)Artikkel i tidsskrift (Annet vitenskapelig) Submitted
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URN: urn:nbn:se:uu:diva-120536OAI: oai:DiVA.org:uu-120536DiVA, id: diva2:303519
Tilgjengelig fra: 2010-03-12 Laget: 2010-03-12 Sist oppdatert: 2018-08-24
Inngår i avhandling
1. Risk Factors for Stroke in Adult Men: A Population-based Study
Åpne denne publikasjonen i ny fane eller vindu >>Risk Factors for Stroke in Adult Men: A Population-based Study
2010 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

In the last decades our knowledge concerning cardiovascular risk factors has grown rapidly through results from longitudinal studies. However, despite new treatment, in Western countries coronary heart disease remains the leading cause of death and stroke is still the leading cause of severe disability.

The studies reported in these papers examine the relationships between stroke/transient ischaemic attack (TIA) and a number of different factors measured on two different occasions in men born in Uppsala 1920-1924 and are epidemiological in their character.

The findings indicate that in addition to already established risk factors, indices of an unhealthy dietary fat intake and high serum lipoprotein(a) are independent predictors of stroke/TIA. Among different glucometabolic variables a low insulin sensitivity index derived from the euglycaemic insulin clamp and proinsulin carries a high predictive value for later stroke, independently of diabetes.

Moreover, cognitive test performance measured with Trail Making Test B at age 70 is a strong and independent predictor of brain infarction, indicating that the risk is already increased in the subclinical phase of milder cognitive dysfunction. Performance at a pre-stroke Trail Making Test is also of predictive value for mortality after first-ever stroke/TIA, but none of the studied pre-stroke variables or cognitive tests was found to be related to dependency after an event.

In summary these studies provide further knowledge about predictors of stroke and of mortality after first-ever stroke. They also indicate the possible importance of new markers of risk, such as the level of lipoprotein(a), profile of fatty acids in the diet, low insulin sensitivity derived from clamp investigations, level of proinsulin, and cognitive performance measured with Trail Making Tests.

 

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2010. s. 65
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 1651-6206 ; 540
Emneord
risk factor, stroke, TIA, lipoproteins, fatty acids, insulin resistance, proinsulin, clamp, cognitive function, epidemiology, Trail Making Test, stroke mortality, dependency
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Medicinsk vetenskap
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urn:nbn:se:uu:diva-120542 (URN)978-91-554-7753-0 (ISBN)
Disputas
2010-05-11, Konferenssalen, Blå Korset, Akademiska sjukhuset, Uppsala, 09:15 (svensk)
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Veileder
Tilgjengelig fra: 2010-04-20 Laget: 2010-03-12 Sist oppdatert: 2018-06-26bibliografisk kontrollert

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