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Host cell recruitment patterns by bone morphogenetic protein-2 releasing hyaluronic acid hydrogels in a mouse subcutaneous environment
Univ Genoa, Dept Expt Med DIMES, Genoa, Italy.;IRCCS Policlin San Martino, Genoa, Italy..
Univ Genoa, Dept Expt Med DIMES, Genoa, Italy.;IRCCS Policlin San Martino, Genoa, Italy.;Alexandria Univ, Conservat Dent Dept, Endodont, Fac Dent, Alexandria, Egypt..
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Kemiska sektionen, Institutionen för kemi - Ångström, Polymerkemi.ORCID-id: 0000-0001-6947-9601
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2017 (engelsk)Inngår i: Regenerative Medicine, ISSN 1746-0751, E-ISSN 1746-076X, Vol. 12, nr 5, s. 525-539Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Aim: This study aimed to identify host cell recruitment patterns in a mouse model in response to rhBMP-2 releasing hyaluronic acid hydrogels and influence of added nano-hydroxyapatite particles on rhBMP-2 release and pattern of bone formation. Materials & methods: Implanted gels were retrieved after implantation and cells were enzymatically dissociated for flow cytometric analysis. Percentages of macrophages, progenitor endothelial cells and putative mesenchymal stem cells were measured. Implants were evaluated for BMP-2 release by ELISA and by histology to monitor tissue formation. Results & conclusion: Hyaluronic acid+BMP-2 gels influenced the inflammatory response in the bone healing microenvironment. Host-derived putative mesenchymal stem cells were major contributors. Addition of hydroxyapatite nanoparticles modified the release pattern of rhBMP-2, resulting in enhanced bone formation.

sted, utgiver, år, opplag, sider
FUTURE MEDICINE LTD , 2017. Vol. 12, nr 5, s. 525-539
Emneord [en]
BMP-2, cell recruitment, controlled release, endothelial progenitor cells, hyaluronic acid hydrogel, macrophages, putative mesenchymal stem cells
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Identifikatorer
URN: urn:nbn:se:uu:diva-335685DOI: 10.2217/rme-2017-0023ISI: 000409196400006PubMedID: 28770657OAI: oai:DiVA.org:uu-335685DiVA, id: diva2:1167906
Forskningsfinansiär
EU, FP7, Seventh Framework Programme, FP7-NMP-214402Tilgjengelig fra: 2017-12-19 Laget: 2017-12-19 Sist oppdatert: 2017-12-19bibliografisk kontrollert

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