uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Demography and mating system shape the genome-wide impact of purifying selection in Arabis alpina
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Stockholm Univ, Sci Life Lab, Dept Ecol Environm & Plant Sci, SE-10691 Stockholm, Sweden..
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för ekologi och genetik, Växtekologi och evolution.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Proceedings of the National Academy of Sciences of the United States of America, ISSN 0027-8424, E-ISSN 1091-6490, Vol. 115, nr 4, s. 816-821Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Plant mating systems have profound effects on levels and structuring of genetic variation and can affect the impact of natural selection. Although theory predicts that intermediate outcrossing rates may allow plants to prevent accumulation of deleterious alleles, few studies have empirically tested this prediction using genomic data. Here, we study the effect of mating system on purifying selection by conducting population-genomic analyses on whole-genome resequencing data from 38 European individuals of the arctic-alpine crucifer Arabis alpina. We find that outcrossing and mixed-mating populations maintain genetic diversity at similar levels, whereas highly self-fertilizing Scandinavian A. alpina show a strong reduction in genetic diversity, most likely as a result of a postglacial colonization bottleneck. We further find evidence for accumulation of genetic load in highly self-fertilizing populations, whereas the genome-wide impact of purifying selection does not differ greatly between mixed-mating and outcrossing populations. Our results demonstrate that intermediate levels of outcrossing may allow efficient selection against harmful alleles, whereas demographic effects can be important for relaxed purifying selection in highly selfing populations. Thus, mating system and demography shape the impact of purifying selection on genomic variation in A. alpina. These results are important for an improved understanding of the evolutionary consequences of mating system variation and the maintenance of mixed-mating strategies.

sted, utgiver, år, opplag, sider
NATL ACAD SCIENCES , 2018. Vol. 115, nr 4, s. 816-821
Emneord [en]
self-fertilization, demographic history, bottleneck, fitness effects, genetic load
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-343798DOI: 10.1073/pnas.1707492115ISI: 000423097800070PubMedID: 29301967OAI: oai:DiVA.org:uu-343798DiVA, id: diva2:1187484
Forskningsfinansiär
Swedish National Infrastructure for Computing (SNIC), snic2014-1-194, b2013022, b2013237Swedish Research CouncilScience for Life Laboratory - a national resource center for high-throughput molecular bioscienceTilgjengelig fra: 2018-03-05 Laget: 2018-03-05 Sist oppdatert: 2018-03-05bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Ågren, Jon

Søk i DiVA

Av forfatter/redaktør
Ågren, Jon
Av organisasjonen
I samme tidsskrift
Proceedings of the National Academy of Sciences of the United States of America

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 4 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf