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Orbital volume and shape in Treacher Collins syndrome
Univ Bourgogne, Hop Francois Mitterand, Ctr Hosp Univ Dijon Bourgogne, Serv Chirurg Maxillofaciale Stomatol Chirurg Plas, Dijon, France..
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Avdelningen för visuell information och interaktion. Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Matematisk-datavetenskapliga sektionen, Institutionen för informationsteknologi, Bildanalys och människa-datorinteraktion.
Aalborg Univ Hosp, Dept Oral & Maxillofacial Surg, Aalborg, Denmark..
Great Ormond St Hosp NHS Trust, Dept Plast Surg, London, England..
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2018 (engelsk)Inngår i: Journal of Cranio-Maxillofacial Surgery, ISSN 1010-5182, E-ISSN 1878-4119, Vol. 46, nr 2, s. 305-311Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Orbito-palpebral reconstruction is a challenge in Treacher Collins syndrome (TCS). This study investigates orbital phenotypes in TCS using cephalometry and orbital shape analysis. Eighteen TCS and 52 control patients were included in this study, using the Dr Warehouse database. Orbital cephalometry was based on 20 landmarks, 10 planes, 16 angles, and 22 distances. Orbits were segmented. Registration-based, age-specific mean models were generated using semi-automatic segmentation, and aligned and compared using color-coded distance maps - mean absolute distance (MAD), Hausdorff distance (HD), and Dice similarity coefficient (DSC). Symmetry was assessed by mirroring and DSC computing. Central orbital depth ( COD) and medial orbital depth ( MOD) allowed 100% of orbits to be classified. COD and lateral orbital depth (LOD) were different from the controls. Average MAD between TCS and controls was <= 1.5 mm, while for HD it was > 1.5 mm, and for DSC <1. TCS orbits were more asymmetrical than controls, and orbital volumes were smaller when age was considered as a confounding factor, and had a trend for normalization with age. This report emphasizes the importance of combining different morphometric approaches in the phenotype characterization of non-trivial structures such as the orbit, and supports composite skeletal and soft-tissue strategies for the management of the peri-orbital region.

sted, utgiver, år, opplag, sider
CHURCHILL LIVINGSTONE , 2018. Vol. 46, nr 2, s. 305-311
Emneord [en]
Treacher collins, Orbits, Volume, Morphometrics, 3D-cephalometry, Midface
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-349828DOI: 10.1016/j.jcms.2017.11.028ISI: 000425711300020PubMedID: 29275073OAI: oai:DiVA.org:uu-349828DiVA, id: diva2:1203684
Tilgjengelig fra: 2018-05-04 Laget: 2018-05-04 Sist oppdatert: 2018-05-04bibliografisk kontrollert

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