uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
No Benefit of Ticagrelor Pretreatment Compared With Treatment During Percutaneous Coronary Intervention in Patients With ST-Segment-Elevation Myocardial Infarction Undergoing Primary Percutaneous Coronary Intervention
Lund Univ, Skane Univ Hosp Lund, Dept Cardiol, Lund, Sweden;Lund Univ, Skane Univ Hosp Lund, Dept Clin Sci, Lund, Sweden.
Lund Univ, Skane Univ Hosp Lund, Dept Cardiol, Lund, Sweden;Lund Univ, Skane Univ Hosp Lund, Dept Clin Sci, Lund, Sweden.
Lund Univ, Skane Univ Hosp Lund, Dept Cardiol, Lund, Sweden;Lund Univ, Skane Univ Hosp Lund, Dept Clin Sci, Lund, Sweden.
Sahlgrens Univ Hosp, Dept Cardiol, Gothenburg, Sweden.
Vise andre og tillknytning
2018 (engelsk)Inngår i: Circulation. Cardiovascular Interventions, ISSN 1941-7640, E-ISSN 1941-7632, Vol. 11, nr 3, artikkel-id e005528Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background-The effects of ticagrelor pretreatment in patients with ST-segment-elevation myocardial infarction undergoing primary percutaneous coronary intervention (PCI) is debated. This study investigated the effects of ticagrelor pretreatment on clinical outcomes in this patient group.

Methods and Results-Patients with ST-segment-elevation myocardial infarction undergoing primary PCI were included from October 2010 to October 2014 in Sweden. Screening was done using the SWEDEHEART register (Swedish Web-System for Enhancement and Development of Evidence-Based Care in Heart Disease Evaluated According to Recommended Therapies). A total of 7433 patients were included for analysis with 5438 patients receiving ticagrelor pretreatment and 1995 patients with ticagrelor given only in the catheterization laboratory. The primary end point of the study was 30-day event rates of a composite of all-cause mortality, myocardial infarction (MI), and stent thrombosis. Secondary end points were mortality, MI, or stent thrombosis alone and major in-hospital bleeding. Crude event rates showed no difference in 30-day composite end point (6.2% versus 6.5%; P=0.69), mortality (4.5% versus 4.7%; P=0.86), MI (1.6% versus 1.7%; P=0.72), or stent thrombosis (0.5% versus 0.4%; P=0.80) with ticagrelor pretreatment. Three different statistical models were used to correct for baseline differences. No difference in the composite end point, mortality, MI, or stent thrombosis was seen between the 2 groups after statistical adjustment. No increase in in-hospital major bleeding rate was observed with ticagrelor pretreatment.

Conclusions-Ticagrelor pretreatment versus ticagrelor given in the catheterization laboratory in patients with ST-segment-elevation myocardial infarction undergoing primary PCI did not improve the composite end point of all-cause mortality or MI or stent thrombosis or its individual components at 30 days.

sted, utgiver, år, opplag, sider
LIPPINCOTT WILLIAMS & WILKINS , 2018. Vol. 11, nr 3, artikkel-id e005528
Emneord [en]
myocardial infarction, percutaneous coronary intervention, ST-elevation myocardial infarction, stents, thrombosis
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-359674DOI: 10.1161/CIRCINTERVENTIONS.117.005528ISI: 000435566100002PubMedID: 29870381OAI: oai:DiVA.org:uu-359674DiVA, id: diva2:1246768
Forskningsfinansiär
Swedish Heart Lung FoundationTilgjengelig fra: 2018-09-10 Laget: 2018-09-10 Sist oppdatert: 2019-01-21bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Lagerqvist, BoJames, Stefan K

Søk i DiVA

Av forfatter/redaktør
Lagerqvist, BoJames, Stefan K
Av organisasjonen
I samme tidsskrift
Circulation. Cardiovascular Interventions

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 3 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf