uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Associations of left atrial volumes and Doppler filling indices with left atrial function in acute myocardial infarction
Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Vasteras, Sweden.
Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Vasteras, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska och farmaceutiska vetenskapsområdet, centrumbildningar mm, Centrum för klinisk forskning, Västerås. Vastmanland Cty Hosp, Dept Clin Physiol, SE-72189 Vasteras, Sweden.ORCID-id: 0000-0001-5731-966x
2019 (engelsk)Inngår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 39, nr 1, s. 85-92Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Recent findings suggest that left atrial (LA) function is more strongly related to adverse prognosis than LA volumes. We aimed to evaluate the associations between LA volumes and Doppler filling indices with LA function. Echocardiographic LA volumes (LAVs), mitral valve early (MV-E) and late (MV-A) peak flow velocities, and mitral atrioventricular plane tissue-Doppler early (TD-e ') and late (TD-a ') peak velocities were obtained in 320 patients with acute myocardial infarction (AMI) free from atrial fibrillation and more than moderate valvular disease. LA function was estimated as the LA emptying fraction (LAEF), that is 100x (LAVmax-LAVmin)/LAVmax. LA reservoir volume was calculated as LAVmax-LAVmin and LA transit volume as LV stroke volume-reservoir volume. In restricted cubic spline regression analyses with multivariable adjustment, a reduced LAEF was strongly associated with smaller reservoir volume, larger transit volume, LAVmax, LAVpreA and especially LAVmin. MV-E linearly increased with a lower LAEF, whereas MV-A decreased but only below LAEF levels of approximately 45%. The resulting E/A ratio showed a sudden increase in LAEF levels below similar to 45%. Lower TD-a ' was linearly associated with a lower LAEF. In conclusion, a reduced atrial function was associated with smaller LA reservoir volume, larger LA transit volume, lower TD-a ', a non-linear decrease in MV-A and a non-linear increase in E/A. Our findings are likely a reflection of the adaptation to sustain LV filling volume and counteracting a rise in pulmonary venous pressure in face of an enhanced LV end-diastolic pressure.

sted, utgiver, år, opplag, sider
WILEY , 2019. Vol. 39, nr 1, s. 85-92
Emneord [en]
diastolic function, Doppler indices, echocardiography, left atrium, myocardial infarction
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-372367DOI: 10.1111/cpf.12533ISI: 000451710300012PubMedID: 29961999OAI: oai:DiVA.org:uu-372367DiVA, id: diva2:1276700
Forskningsfinansiär
Erik, Karin och Gösta Selanders FoundationThe Swedish Medical AssociationTilgjengelig fra: 2019-01-08 Laget: 2019-01-08 Sist oppdatert: 2019-01-08bibliografisk kontrollert

Open Access i DiVA

fulltekst(397 kB)68 nedlastinger
Filinformasjon
Fil FULLTEXT01.pdfFilstørrelse 397 kBChecksum SHA-512
247e29c731506894685d6703e968c18718ff4a06f8c9db21ed2be4669f244c781e5cb758e56adba0e801c1c56a759c0bf5fb740945e2934c2e42ce9359fe581d
Type fulltextMimetype application/pdf

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Hedberg, Pär

Søk i DiVA

Av forfatter/redaktør
Hedberg, Pär
Av organisasjonen
I samme tidsskrift
Clinical Physiology and Functional Imaging

Søk utenfor DiVA

GoogleGoogle Scholar
Totalt: 68 nedlastinger
Antall nedlastinger er summen av alle nedlastinger av alle fulltekster. Det kan for eksempel være tidligere versjoner som er ikke lenger tilgjengelige

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 137 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf