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The Effects of Mast Cell Proteases on Human Lung Cells Population
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Biologiska sektionen, Institutionen för biologisk grundutbildning.
2019 (engelsk)Independent thesis Advanced level (degree of Master (Two Years)), 30 poäng / 45 hpOppgave
Abstract [en]

Asthma is a devastating disease characterized by airway obstruction, inflammation, and bronchial hyperreactivity. Previous studies have implicated mast cells in the pathology of asthma, yet the role and function of mast cells in the early stage of human asthma development cannot be investigated in vivo for ethical reasons. In the present study, we investigated the mast cell proteases actions on primary cell populations, including primary human lung fibroblast (HLF) and primary human small airway epithelial cells (HSAEC). Mast cell chymase caused significant morphological effects on primary HLF by degrading extracellular matrix (ECM), such as fibronectin and collagen I, and activation of pro-MMP2. Chymase also regulated the cytokine synthesis and gene expression in primary HLF after 24 h treatment. Both tryptase and chymase stimulated primary HSAEC proliferation. These results indicate that mast cell proteases can have a profound impact during asthmatic airway responses.

sted, utgiver, år, opplag, sider
2019. , s. 39
Emneord [en]
asthma, primary cell, tryptase, chymase
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-385409OAI: oai:DiVA.org:uu-385409DiVA, id: diva2:1324131
Utdanningsprogram
Master Programme in Biology
Veileder
Examiner
Tilgjengelig fra: 2019-06-13 Laget: 2019-06-13 Sist oppdatert: 2019-06-13bibliografisk kontrollert

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