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3D-printed PLA/HA composite structures as synthetic trabecular bone: a feasibility study using Fused Deposition Modelling
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. (BioMaterial Systems)
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap.
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. (BioMaterial Systems)
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Tekniska sektionen, Institutionen för teknikvetenskaper, Tillämpad materialvetenskap. (BioMaterial Systems)
(engelsk)Manuskript (preprint) (Annet vitenskapelig)
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-390621OAI: oai:DiVA.org:uu-390621DiVA, id: diva2:1342152
Tilgjengelig fra: 2019-08-12 Laget: 2019-08-12 Sist oppdatert: 2019-08-13
Inngår i avhandling
1. Mechanical analyses of trabecular bone and its interaction with implants
Åpne denne publikasjonen i ny fane eller vindu >>Mechanical analyses of trabecular bone and its interaction with implants
2019 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Bone substitute materials or implants are commonly used in the surgical treatment of bone fractures. However, severe complications are sometimes reported. In order to improve fracture treatment where the interior, porous trabecular bone is involved, it is important to better understand the mechanical properties of this bone and how it interacts with the substitutes/implants, and this was the aim of this thesis.

Since one of the key mechanical properties of trabecular bone, i.e. the elastic moduli at the tissue level, was not consistently reported in the literature, the results from four widely applied methods were first summarized and presented in a review paper.

Furthermore, to improve the analysis of the mechanical behavior of bone and its interaction with implants, a new digital volume correlation (DVC) technique was proposed based on higher-order finite elements.

We further proposed a method to estimate the elastic modulus at the tissue level by compression of single trabeculae within a synchrotron radiation micro-computed tomograph (SRµCT). Full-field displacements were estimated by DVC, which also provided boundary conditions for a finite element model. The proposed method shows potential to estimate trabecular mechanical properties at the tissue level.

Further, strains and cracks of a trabecular structure under compression till fracture were characterized at the single trabecular level, with DVC applied on high-resolution images from SRµCT.

The effect of augmentation materials on the engagement of screws inserted into trabecular bone was evaluated in human femoral bone, with and without real-time SRµCT. A newly developed tissue adhesive indicated a potential benefit of this material to the primary implant stability compared to a cement and no augmentation.

Finally, a trabecular structure of PLA/HA composite material was printed using a fused deposition modelling method as a preliminary step towards better synthetic models of trabecular bone. The synthetic trabecular structure was evaluated using micro-CT, compression and screw pull-out testing.

In conclusion, methods to estimate strains and mechanical properties of trabecular bone were proposed, insights into interactions between trabecular bone and augmentation/implants were gained, as well as a first step towards a synthetic trabecular model, which may contribute to further mechanical analyses and/or improved clinical treatments of trabecular bone.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2019. s. 65
Serie
Digital Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1651-6214 ; 1836
Emneord
Trabecular bone, Elastic modulus, Digital volume correlation, Pullout resistance, Micro-computed tomography.
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-385143 (URN)978-91-513-0715-2 (ISBN)
Disputas
2019-09-18, Ångström 8001, Lägerhyddsvägen 1, Uppsala, 13:15 (engelsk)
Opponent
Veileder
Tilgjengelig fra: 2019-08-28 Laget: 2019-08-12 Sist oppdatert: 2019-09-17

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