uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Microvascular capillary assessment in relation to forearm blood flow
Danderyd Hosp, Dept Clin Sci, Stockholm, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper, Klinisk epidemiologi.ORCID-id: 0000-0003-2335-8542
Karolinska Univ Hosp, Div Clin Chem, Stockholm, Sweden.
Karolinska Univ Hosp, Dept Med, Stockholm, Sweden.ORCID-id: 0000-0003-2885-211X
2019 (engelsk)Inngår i: Clinical Physiology and Functional Imaging, ISSN 1475-0961, E-ISSN 1475-097X, Vol. 39, nr 5, s. 322-326Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Objective To study whether vascular reactivity as assessed by the methods forearm blood flow (FBF) and postocclusive reactive hyperaemia (PRH) in the nail fold was related as a measure of endothelium-dependent vasodilation in the microcirculation. Methods Microvascular reactivity was assessed in forearm blood flow and in the nail fold by vital capillaroscopy of individual microvessels as postocclusive reactive hyperaemia. Vascular reactivity was assessed at baseline (n = 25) as well as after infusion of acetylcholine and of sodium nitroprusside (n = 13). We also performed a multivariate regression analysis to assess whether forearm blood flow or flow-mediated dilatation related to postocclusive reactive hyperaemia. Results This study showed a distinct microvascular response to both acetylcholine (endothelium-dependent vasodilation) and sodium nitroprusside (endothelium-independent vasodilation) during forearm blood flow assessment and postocclusive reactive hyperaemia assessment in the nail fold (n = 13). These changes were inversely related (r- = -0 center dot 57; P<0 center dot 05). Conclusions Forearm blood flow was inversely correlated to postocclusive reactive hyperaemia. Postocclusive reactive hyperaemia was shortened after infusion with both acetylcholine and sodium nitroprusside. This occurred in parallel with the expected increase in forearm blood flow, conceivably reflecting that both methods can be used to assess endothelium-dependent vasodilation in the microcirculation.

sted, utgiver, år, opplag, sider
WILEY , 2019. Vol. 39, nr 5, s. 322-326
Emneord [en]
capillaroscopy, endothelial function, forearm blood flow, microcirculation, postocclusive reactive hyperaemia
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-393648DOI: 10.1111/cpf.12575ISI: 000479117100004PubMedID: 31074581OAI: oai:DiVA.org:uu-393648DiVA, id: diva2:1354572
Forskningsfinansiär
Knut and Alice Wallenberg FoundationTilgjengelig fra: 2019-09-25 Laget: 2019-09-25 Sist oppdatert: 2019-09-25bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Lind, Lars

Søk i DiVA

Av forfatter/redaktør
Lind, LarsFreyschuss, Anna
Av organisasjonen
I samme tidsskrift
Clinical Physiology and Functional Imaging

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 37 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf