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Cell Cycle Regulator p27 Mediates Body Mass IndexEffects in Ovarian Cancer in FIGO-stages I-II
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Reproduktionsbiologi.ORCID-id: 0000-0001-9840-2240
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för immunologi, genetik och patologi, Medicinsk genetik och genomik. (Helena Åkerud)
Department of Pathology, Halmstad Medical Center Hospital, Halmstad, Sweden.
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för kvinnors och barns hälsa, Forskargrupper (Inst. för kvinnor och barns hälsa), Reproduktiv hälsa. (Reproduktiv hälsa/Sundström Poromaa)ORCID-id: 0000-0002-2491-2042
2019 (engelsk)Inngår i: Cancer Genomics & Proteomics, ISSN 1109-6535, E-ISSN 1790-6245, Vol. 16, nr 6, s. 443-450Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Background/Aim: The aim of the present study was to evaluate the association between body mass index (BMI), the biomarker p27, and the clinical factors in FIGO-stages I-II ovarian cancer. Patients and Methods: A total of 128 patients with ovarian cancer were included in the study. For testing differences in univariate analyzes we used the Pearson's Chi-square test and the log-rank test. For multivariate analyses the logistic regression and Cox regression models were used with recurrent disease and disease free survival as endpoints, respectively. Results: Patients with BMI <= 25 kg/m(2) had a significantly better 5-year disease free survival compared with patients with BMI >25 kg/m(2) in the total series of patients (p=0.008), and in the series of patients (n=77) with non-serous tumors (p=0.047). Patients with p27-positive non-serous tumors had higher survival compared to patients with p27-negative non-serous tumors (p=0.020). Conclusion: The cell cycle regulator p27 mediates BMI effects in ovarian cancer in FIGO-stages I-II.

sted, utgiver, år, opplag, sider
International Institute of Anticancer Research, 2019. Vol. 16, nr 6, s. 443-450
Emneord [en]
BMI, p27, non-serous tumors, ovarian cancer, FIGOstages I-II.
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Identifikatorer
URN: urn:nbn:se:uu:diva-396005DOI: 10.21873/cgp.20148ISI: 000493397500004PubMedID: 31659099OAI: oai:DiVA.org:uu-396005DiVA, id: diva2:1366235
Tilgjengelig fra: 2019-10-28 Laget: 2019-10-28 Sist oppdatert: 2019-11-18bibliografisk kontrollert

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