Logo: to the web site of Uppsala University

uu.sePublikasjoner fra Uppsala universitet
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Positron emission tomography (11)C-methionine and survival in patients with low-grade gliomas
Uppsala universitet, Medicinska vetenskapsområdet, Medicinska fakulteten, Institutionen för neurovetenskap, Neurologi.
Vise andre og tillknytning
2001 Inngår i: Cancer, Vol. 92, nr 6, s. 1541-9Artikkel i tidsskrift (Fagfellevurdert) Published
sted, utgiver, år, opplag, sider
2001. Vol. 92, nr 6, s. 1541-9
Identifikatorer
URN: urn:nbn:se:uu:diva-90047OAI: oai:DiVA.org:uu-90047DiVA, id: diva2:162103
Tilgjengelig fra: 2002-10-25 Laget: 2002-10-25bibliografisk kontrollert
Inngår i avhandling
1. In Search of Prognostic Factors in Grade 2 Gliomas
Åpne denne publikasjonen i ny fane eller vindu >>In Search of Prognostic Factors in Grade 2 Gliomas
2002 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

Grade 2 gliomas are malignant brain tumours affecting otherwise healthy adults. Although the long-term prognosis is poor, many patients are well and may have a high quality of life for several years. There is, however, a large variability in the natural course of the disease which makes it essential to identify patients who might benefit from early surgery or radio-therapy. The aim of the present thesis was to define new and clinically useful prognostic markers that may assist in the initial treatment decision and in patient follow-up.

A retrospective study of 189 patients with gliomas WHO grade 2 showed no advantage in survival of early tumour resection or radiotherapy, and confirmed that histological subtype and patient age are the most important predictors of survival (I). In 89 patients, the pre-treatment uptake of 11C-methionine (MET) measured with positron emission tomography (PET) was identified as a prognostic marker for survival (II). At the time of tumour progression, irradiated tumours demonstrated signs of a residual radiotherapeutic effect that correlated with the pre-treatment uptake of MET (III). Pre-treatment uptake of MET may, therefore, be important both in predicting the natural course of the disease and the response after treatment. Immunohistochemical staining of 40 tumour samples showed an inverse association between the number of tumour cells expressing platelet-derived growth factor alpha receptor (PDGFRa) and survival (IV). Also, a reduction was observed in the number of receptor-positive cells after malignant transformation, supporting the prognostic value of PDGFRa.

Lumbar puncture was performed in eight patients with newly diagnosed low-grade gliomas to identify three important growth factors in tumour development. Neither PDGF nor vascular endothelial growth factor (VEGF) were detected in the cerebrospinal fluid (CSF), and fibroblast growth factor 2 (FGF-2) was measurable at extremely low concentrations in two of the patients (V). A proteome screening of the CSF, using two-dimensional gel electrophoresis and mass spectrometry, detected alpha 2-HS glycoprotein at significantly higher concentrations than in a control group (VI). This glycoprotein emerges as a novel substance in glioma research and may be of great interest because of its suggested involvement in the embryonic development of the neocortex.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2002. s. 39
Serie
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1194
Emneord
Neurosciences, low-grade glioma, positron emission tomography, platelet-derived growth factor receptor, mass spectrometry, alpha 2-HS glycoprotein, Neurovetenskap
HSV kategori
Forskningsprogram
Neurologi
Identifikatorer
urn:nbn:se:uu:diva-2789 (URN)91-554-5435-6 (ISBN)
Disputas
2002-12-14, Rudbecksalen, Uppsala, 13:15
Opponent
Tilgjengelig fra: 2002-10-25 Laget: 2002-10-25 Sist oppdatert: 2013-05-23bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Av organisasjonen

Søk utenfor DiVA

GoogleGoogle Scholar

urn-nbn

Altmetric

urn-nbn
Totalt: 362 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf