uu.seUppsala universitets publikasjoner
Endre søk
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf
Endothelial vasodilatory function is predicted by circulating apolipoprotein B and HDL in healthy humans
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. (Akut- och intermedicin)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. (Akut- och internmedicin)
Uppsala universitet, Medicinska och farmaceutiska vetenskapsområdet, Medicinska fakulteten, Institutionen för medicinska vetenskaper. (Akut- och intermedicin)
Vise andre og tillknytning
2002 (engelsk)Inngår i: Lipids, ISSN 0024-4201, E-ISSN 1558-9307, Vol. 37, nr 12, s. 1135-1140Artikkel i tidsskrift (Fagfellevurdert) Published
Abstract [en]

Endothelium-dependent vasodilation (EDV), LDL particle size, and antibodies against oxidized LDL (oxLDLab) have been shown to be related to the development of atherosclerosis and cardiovascular disease. In this study, we investigated whether LDL particle size, oxLDLab, apolipoproteins, and lipoproteins are related to endothelial vasodilatory function in a population sample of 58 apparently healthy subjects aged 20 to 69 yr. EDV and endothelium-independent vasodilation (EIDV) were studied in the forearm during local administration of methacholine chloride (2 and 4 microg/min) or sodium nitroprusside (5 and 10 microg/min). Forearm blood flow was determined with venous occlusion plethysmography. In multiple stepwise regression analyses, neither oxLDLab nor small LDL particles were significantly predictive of endothelial vasodilatory function. Instead, a high level of apolipoprotein B (apoB) was an independent predictor of both attenuated EDV and EIDV (r = -0.43, P < 0.01, and r = -0.34, P < 0.05, respectively). HDL cholesterol, on the other hand, was the only lipid variable that was significantly related to the EDV to EIDV ratio, an index of endothelial vasodilatory function (r = 0.35, P < 0.01). The inverse associations between apoB and both EDV and EIDV indicate that apoB might be an early marker of structural vascular changes in healthy subjects, whereas HDL seems to be more specifically related to endothelial vasodilatory function.

sted, utgiver, år, opplag, sider
2002. Vol. 37, nr 12, s. 1135-1140
HSV kategori
Identifikatorer
URN: urn:nbn:se:uu:diva-90409DOI: 10.1007/s11745-002-1010-3PubMedID: 12617465OAI: oai:DiVA.org:uu-90409DiVA, id: diva2:162753
Tilgjengelig fra: 2003-05-06 Laget: 2003-05-06 Sist oppdatert: 2017-12-14bibliografisk kontrollert
Inngår i avhandling
1. Lipids and Endothelium-Dependent Vasodilation
Åpne denne publikasjonen i ny fane eller vindu >>Lipids and Endothelium-Dependent Vasodilation
2003 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Alternativ tittel[sv]
Lipider och endotelberoende vasodilatation
Abstract [en]

Impaired endothelium-dependent vasodilation (EDV) is associated with atherosclerotic cardiovascular disease as well as several of its risk factors.

The aim of the present thesis was to investigate how lipids influence EDV in the vascular bed of the human forearm.

Apolipoprotein B was inversely associated with both EDV and endothelium-independent vasodilation (EIDV) in healthy subjects aged 20-69 years. HDL cholesterol was associated with the EDV to EIDV ratio (EFI). Small LDL particles and antibodies against oxidized LDL were not associated with endothelial vasodilatory function.

The EFI in young, healthy subjects was positively associated with alpha-linolenic acid proportion, but inversely associated with myristic acid in men only. Eicosapentaenoic acid was positively associated with EDV, whereas dihomo-gamma-linolenic acid was inversely associated with both EDV and EIDV in men.

Acute elevation of long-chain fatty acids with Intralipid®/heparin infusion in young, healthy subjects impaired EDV after 2 h. This impairment could be prevented by co-infusing vitamin C, diclophenac or L-arginine. Acute elevation of both medium-chain and long-chain fatty acids during Structolipid®/heparin infusion did not impair EDV.

An ordinary meal (34 E% fat) transiently attenuated EDV at 1 hour. No attenuation in EDV was observed after meals containing 20 and 3 E% fat.

These findings show that the endothelial vasodilatory function is associated with fatty acid profile in serum in the fasting state and during acute fatty acid elevation, as well as with apolipoprotein B and HDL cholesterol. Furthermore, lowering dietary fat content to 20 E% or less preserves endothelial vasodilatory function and might therefore protect against atherosclerosis.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2003. s. 78
Serie
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Medicine, ISSN 0282-7476 ; 1263
Emneord
Medicine, Atherosclerosis, endothelium, vasodilation, nitric oxide, fatty acid, meal, diet, lipoprotein, cyclooxygenase, diclophenac, L-arginine, LDL, human, Medicin
HSV kategori
Forskningsprogram
Internmedicin
Identifikatorer
urn:nbn:se:uu:diva-3424 (URN)91-554-5633-2 (ISBN)
Disputas
2003-05-26, Aulan, Thoraxhuset - ingång 50, Akademiska sjukhuset, Uppsala, 09:15
Opponent
Veileder
Tilgjengelig fra: 2003-05-06 Laget: 2003-05-06 Sist oppdatert: 2010-10-21bibliografisk kontrollert

Open Access i DiVA

Fulltekst mangler i DiVA

Andre lenker

Forlagets fulltekstPubMed

Personposter BETA

Steer, PeterBasu, SamarVessby, BengtLind, Lars

Søk i DiVA

Av forfatter/redaktør
Steer, PeterBasu, SamarVessby, BengtLind, Lars
Av organisasjonen
I samme tidsskrift
Lipids

Søk utenfor DiVA

GoogleGoogle Scholar

doi
pubmed
urn-nbn

Altmetric

doi
pubmed
urn-nbn
Totalt: 537 treff
RefereraExporteraLink to record
Permanent link

Direct link
Referera
Referensformat
  • apa
  • ieee
  • modern-language-association
  • vancouver
  • Annet format
Fler format
Språk
  • de-DE
  • en-GB
  • en-US
  • fi-FI
  • nn-NO
  • nn-NB
  • sv-SE
  • Annet språk
Fler språk
Utmatningsformat
  • html
  • text
  • asciidoc
  • rtf