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Deranged spontaneous behaviour and decrease in cholinergic muscarinic receptors in hippocampus in the adult rat, after neonatal exposure to the flame-retardant, 2,2',4,4',5-pentabromodiphenyl ether (PBDE 99).
Uppsala universitet, Teknisk-naturvetenskapliga vetenskapsområdet, Teknisk-naturvetenskapliga fakulteten, Biologiska sektionen, Institutionen för evolutionsbiologi, Ekotoxikologi.
Artikkel i tidsskrift (Fagfellevurdert) Submitted
Identifikatorer
URN: urn:nbn:se:uu:diva-92205OAI: oai:DiVA.org:uu-92205DiVA, id: diva2:165192
Tilgjengelig fra: 2004-10-06 Laget: 2004-10-06bibliografisk kontrollert
Inngår i avhandling
1. Neonatal Developmental Neurotoxicity of Brominated Flame Retardants, the Polybrominated Diphenyl Ethers (PBDEs)
Åpne denne publikasjonen i ny fane eller vindu >>Neonatal Developmental Neurotoxicity of Brominated Flame Retardants, the Polybrominated Diphenyl Ethers (PBDEs)
2004 (engelsk)Doktoravhandling, med artikler (Annet vitenskapelig)
Abstract [en]

This thesis examines developmental neurotoxic effects of polybrominated diphenyl ethers (PBDEs), PBDE 99, PBDE 153, and the fully brominated PBDE 209, after exposure during the newborn period in rodents.

Our environment contains vast numbers of contaminants, including the flame retardants, PBDEs. The PBDEs are widely found in the environment and are increasing in human milk. Individuals can be exposed to PBDEs during their whole lifetime, and especially during the lactation period. The neonatal period, coinciding with the lactation period, is characterized in many mammalian species by rapid growth and development of the immature brain. It has been shown that numerous toxicants can induce permanent disorders in brain function when administered to the neonatal mouse during the brain growth spurt (BGS). In mice and rats this period is postnatal, spanning over the first 3-4 weeks of life, while in humans, BGS begins during the third trimester of pregnancy and continues throughout the first two years of life.

The present studies identified a defined critical period during BGS in mice when the brain is vulnerable to insults of low doses of PBDEs and that it is the presence of PBDEs or their metabolites in the brain during this critical period that is crucial to evoking neurotoxic effects. The effects observed are permanent altered spontaneous behavior, reduced habituation, deficits in learning and memory, and disturbances in the cholinergic system. These effects worsen with age.

The ability of PBDEs to induce neurotoxic effects does not appear to be gender-, strain- or species-specific, because the neurotoxic effects are induced in rats and male and female mice of different strains.

The developmental neurotoxic effects of PBDEs are similar to those observed for polychlorinated biphenyls (PCBs) and possible interactive effects of PBDEs and other environmental contaminants are therefore of concern.

sted, utgiver, år, opplag, sider
Uppsala: Acta Universitatis Upsaliensis, 2004. s. 62
Serie
Comprehensive Summaries of Uppsala Dissertations from the Faculty of Science and Technology, ISSN 1104-232X ; 1020
Emneord
Biology, brominated flame retardants, polybrominated diphenyl ethers, PBDE, neonatal, development, neurotoxicity, behaviour, cholinergic system, Biologi
HSV kategori
Identifikatorer
urn:nbn:se:uu:diva-4576 (URN)91-554-6053-4 (ISBN)
Disputas
2004-10-29, Lindahlsalen, EBC, Norbyvägen 18A, Uppsala, 09:00
Opponent
Veileder
Tilgjengelig fra: 2004-10-06 Laget: 2004-10-06 Sist oppdatert: 2011-02-09bibliografisk kontrollert

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