Background: The use of bisphenol A (BPA) in plastic materials has been replaced by analogs to this compound due to increasing concern of reproductive and endocrinedisruptive effects on human health. Unlike BPA, relatively little is known about these analogs and their potential toxicity. Early development during pregnancy is sensitive to changes in the hormonal milieu, which is of particular concern due to the extensive exposure to these analogs in humans reported by epidemiological studies.
Aim: To compile published epidemiological studies on prenatal exposure to bisphenol A analogs and evaluate these compounds’ potential effects on growth.
Methods: A literature review was conducted through a literature search using Pubmed and Web of Science to identify relevant published articles. The literature search included published articles between the years 2017-2022.
Results: The effect on growth in fetuses and newborns as a result of exposure to alternative bisphenols has shown inconsistent results in epidemiological studies. The most observed effect was deviating fetal and newborn weight. Gender specific differences in growth were also observed in some of the included studies.
Conclusion: The association between prenatal exposure to bisphenol A analogs and effects on growth is unclear due to the inconsistent results reported by epidemiological studies. Further investigation of analogs to bisphenol A and their potential effects on fetuses and humans is needed to evaluate if these analogs are safer to use than BPA.